NO981093L - 2-£2£(2-hydroksyetyl)amino|etyl|-5-££2-metylamino)etyl|amino|-indazolo£4,3-gh|isokinolin-6(2H)-on som antitumor middel - Google Patents

2-£2£(2-hydroksyetyl)amino|etyl|-5-££2-metylamino)etyl|amino|-indazolo£4,3-gh|isokinolin-6(2H)-on som antitumor middel

Info

Publication number
NO981093L
NO981093L NO981093A NO981093A NO981093L NO 981093 L NO981093 L NO 981093L NO 981093 A NO981093 A NO 981093A NO 981093 A NO981093 A NO 981093A NO 981093 L NO981093 L NO 981093L
Authority
NO
Norway
Prior art keywords
ethyl
amino
indazolo
methylamino
hydroxyethyl
Prior art date
Application number
NO981093A
Other languages
English (en)
Norwegian (no)
Other versions
NO981093D0 (no
Inventor
Ernesto Menta
Ambrogio Oliva
Silvano Spinelli
Paul Krapcho
Original Assignee
Boehringer Mannheim Italia
Univ Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia, Univ Vermont filed Critical Boehringer Mannheim Italia
Publication of NO981093D0 publication Critical patent/NO981093D0/no
Publication of NO981093L publication Critical patent/NO981093L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO981093A 1995-09-13 1998-03-12 2-£2£(2-hydroksyetyl)amino|etyl|-5-££2-metylamino)etyl|amino|-indazolo£4,3-gh|isokinolin-6(2H)-on som antitumor middel NO981093L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI001904A IT1277576B1 (it) 1995-09-13 1995-09-13 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale
PCT/EP1996/003935 WO1997010245A1 (en) 1995-09-13 1996-09-09 2-[2-[(2-HYDROXYETHYL)AMINO]ETHYL]-5-[[2-METHYLAMINO)ETHYL]AMINO]INDAZOLO[4,3-gh]ISOQUINOLIN-6(2H)-ONE AS ANTITUMOR AGENT

Publications (2)

Publication Number Publication Date
NO981093D0 NO981093D0 (no) 1998-03-12
NO981093L true NO981093L (no) 1998-03-12

Family

ID=11372237

Family Applications (1)

Application Number Title Priority Date Filing Date
NO981093A NO981093L (no) 1995-09-13 1998-03-12 2-£2£(2-hydroksyetyl)amino|etyl|-5-££2-metylamino)etyl|amino|-indazolo£4,3-gh|isokinolin-6(2H)-on som antitumor middel

Country Status (15)

Country Link
US (1) US6034092A (hu)
EP (1) EP0876369A1 (hu)
JP (1) JPH11512409A (hu)
KR (1) KR19990044614A (hu)
CN (1) CN1196055A (hu)
AR (1) AR003997A1 (hu)
AU (1) AU6988296A (hu)
BR (1) BR9610601A (hu)
CZ (1) CZ286654B6 (hu)
HU (1) HUP9901348A3 (hu)
IL (1) IL123619A0 (hu)
IT (1) IT1277576B1 (hu)
NO (1) NO981093L (hu)
WO (1) WO1997010245A1 (hu)
ZA (1) ZA967706B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747039B2 (en) * 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
WO2006081431A2 (en) * 2005-01-28 2006-08-03 Xanthus Pharmaceuticals, Inc. Compounds for treating inflammatory and demyelinating diseases
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56782B1 (en) * 1982-07-23 1991-12-18 Warner Lambert Co Substituted anthra(1,9-cd)pyrazol-6(2h)-ones
US5519029A (en) * 1992-09-08 1996-05-21 Boehringer Mannheim Italia, S.P.A. 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
PT662076E (pt) * 1992-09-08 2001-09-28 Univ Vermont Isoquinoindazol-6-(2h)-onas substituidas por 2-aminoalquil-5-aminoalquilamino com actividade antitumor
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles

Also Published As

Publication number Publication date
US6034092A (en) 2000-03-07
CZ286654B6 (cs) 2000-05-17
HUP9901348A3 (en) 2000-03-28
NO981093D0 (no) 1998-03-12
WO1997010245A1 (en) 1997-03-20
JPH11512409A (ja) 1999-10-26
ITMI951904A0 (it) 1995-09-13
CN1196055A (zh) 1998-10-14
ZA967706B (en) 1997-03-25
IT1277576B1 (it) 1997-11-11
ITMI951904A1 (it) 1997-03-13
BR9610601A (pt) 1999-12-21
AU6988296A (en) 1997-04-01
CZ75098A3 (cs) 1998-07-15
HUP9901348A2 (hu) 1999-08-30
EP0876369A1 (en) 1998-11-11
IL123619A0 (en) 1998-10-30
KR19990044614A (ko) 1999-06-25
AR003997A1 (es) 1998-09-30

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application