ES2182852T3 - Derivados de prolinamida. - Google Patents
Derivados de prolinamida.Info
- Publication number
- ES2182852T3 ES2182852T3 ES95101059T ES95101059T ES2182852T3 ES 2182852 T3 ES2182852 T3 ES 2182852T3 ES 95101059 T ES95101059 T ES 95101059T ES 95101059 T ES95101059 T ES 95101059T ES 2182852 T3 ES2182852 T3 ES 2182852T3
- Authority
- ES
- Spain
- Prior art keywords
- prolinamide derivatives
- salt
- prolinamide
- derivatives
- usuful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE PROPORCIONA UN DERIVADO DE PROLINEAMIDA REPRESENTADO POR LA FORMULA (I): O UNA SAL O HIDRATO DE ELLA O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE ELLA, QUE TIENE UNA ACTIVIDAD DE INHIBICION DE PROTEASA, SE USA COMO UN INGREDIENTE ACTIVO DE COMPOSICIONES FARMACEUTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP773394 | 1994-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2182852T3 true ES2182852T3 (es) | 2003-03-16 |
Family
ID=11673914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95101059T Expired - Lifetime ES2182852T3 (es) | 1994-01-27 | 1995-01-26 | Derivados de prolinamida. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5744487A (es) |
EP (1) | EP0669317B1 (es) |
KR (1) | KR950032114A (es) |
CN (1) | CN1066712C (es) |
AT (1) | ATE223378T1 (es) |
AU (1) | AU1025795A (es) |
CA (1) | CA2140598C (es) |
DE (1) | DE69528005T2 (es) |
ES (1) | ES2182852T3 (es) |
FI (1) | FI950309A (es) |
HU (1) | HUT72062A (es) |
NO (1) | NO950297L (es) |
NZ (1) | NZ270395A (es) |
RU (1) | RU95101048A (es) |
TW (1) | TW306917B (es) |
ZA (1) | ZA95631B (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
US5561146A (en) * | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
DE4443390A1 (de) * | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
CZ237697A3 (cs) * | 1995-02-10 | 1998-04-15 | Basf Aktiengesellschaft | Derivát peptidického p-amidinobenzylamidu jako inhibitor thrombinu a meziprodukty pro jeho přípravu |
SK104697A3 (en) * | 1995-02-17 | 1998-11-04 | Basf Ag | Novel dipeptide amidines as thrombin inhibitors |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
CA2176414A1 (en) * | 1995-05-18 | 1996-11-19 | S. David Kimball | Acyl guanidine and amidine prodrugs |
SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
EP0846682B9 (en) * | 1995-07-26 | 2003-05-14 | Mitsubishi Chemical Corporation | Penicillaminamide derivatives |
AR005245A1 (es) * | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
AU1990197A (en) * | 1996-03-12 | 1997-10-01 | Bristol-Myers Squibb Company | Carbamyl guanidine and amidine prodrugs |
US5811402A (en) * | 1996-03-22 | 1998-09-22 | Eli Lilly And Company | Antithrombotic diamides |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
US6200967B1 (en) | 1996-06-25 | 2001-03-13 | Eli Lilly And Company | Anticoagulant agents |
WO1997049404A1 (en) * | 1996-06-25 | 1997-12-31 | Eli Lilly And Company | Anticoagulant agents |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
ATE218124T1 (de) * | 1997-11-19 | 2002-06-15 | Mitsubishi Chem Corp | Ein 1/2-sulfat des ((s)-1-((s)-2-((trans-4- aminocyclohexylmethyl)carbamoyl)-pyrrolidine-1- carbonyl)-2-iso-propylthio-2-methylpropyl)- carbamidsäurepropylesters |
SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
SE9802939D0 (sv) | 1998-09-01 | 1998-09-01 | Astra Ab | New process |
SE9804313D0 (sv) * | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
CA2355792A1 (en) | 1999-01-13 | 2000-07-20 | Astrazeneca Ab | New amidinobenzylamine derivatives and their use as thrombin inhibitors |
FR2791683A1 (fr) * | 1999-03-30 | 2000-10-06 | Synthelabo | Derives de n-sulfonyl-dipeptides, leur preparation et leur application en therapeutique |
AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
US6316488B1 (en) * | 1999-06-17 | 2001-11-13 | Merck & Co., Inc. | Antibiotic compound |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
NZ538572A (en) * | 2000-08-11 | 2006-09-29 | Dendreon Corp | Non-covalent inhibitors of urokinase and blood vessel formation |
US6586405B2 (en) | 2000-08-11 | 2003-07-01 | Corvas International, Inc. | Non-covalent inhibitors of urokinase and blood vessel formation |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
US7129233B2 (en) * | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
US7001887B2 (en) * | 2001-02-02 | 2006-02-21 | Chugai Seiyaku Kabushiki Kaisha | Peptide derivatives |
US7195759B2 (en) * | 2001-06-06 | 2007-03-27 | The University Of Manitoba | Therapeutic uses of glandular kallikrein |
US20090162342A1 (en) * | 2001-06-07 | 2009-06-25 | Sanomune Inc. | Therapeutic uses of glandular kallikrein |
AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
DK1485345T3 (da) | 2002-03-11 | 2008-11-03 | Curacyte Ag | Urokinaseinhibitorer, deres fremstilling og anvendelse |
SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
DE10234058A1 (de) * | 2002-07-26 | 2004-02-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Benzoesäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
DE102005044319A1 (de) | 2005-09-16 | 2007-03-22 | Curacyte Chemistry Gmbh | 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa |
CN101033209B (zh) * | 2006-03-09 | 2014-08-27 | 上海医药工业研究院 | 药物中间体(2s,4r)-4-羟基-n,n-二甲基-2-吡咯烷甲酰胺的制备方法 |
DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
CN102464701B (zh) * | 2010-11-08 | 2015-10-21 | 上海医药工业研究院 | 一类新型化合物、其制备方法及用途 |
JP5923110B2 (ja) * | 2010-12-21 | 2016-05-24 | ザ メディスンズ カンパニー (ライプチヒ) ゲーエムベーハー | トリプシン様セリンプロテアーゼ阻害剤、その調製、ならびに凝固因子IIaおよびXaの選択的阻害剤としての使用 |
WO2013173923A1 (en) | 2012-05-25 | 2013-11-28 | Diamedica, Inc. | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
ES2625548T3 (es) | 2012-06-04 | 2017-07-19 | DiaMedica Therapeutics Inc. | Isoformas de glicosilación de la calicreína-1 tisular humana |
WO2018165551A1 (en) | 2017-03-09 | 2018-09-13 | Diamedica Inc. | Dosage forms of tissue kallikrein 1 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0813834B2 (ja) * | 1990-08-01 | 1996-02-14 | 日東紡績株式会社 | トリペプチド誘導体及びそれを有効成分とする蛋白分解酵素阻害剤 |
CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
WO1993015756A1 (en) * | 1992-02-14 | 1993-08-19 | Corvas International, Inc. | Inhibitors of thrombosis |
AU675981B2 (en) * | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
-
1995
- 1995-01-19 CA CA002140598A patent/CA2140598C/en not_active Expired - Lifetime
- 1995-01-19 AU AU10257/95A patent/AU1025795A/en not_active Abandoned
- 1995-01-21 TW TW084100530A patent/TW306917B/zh active
- 1995-01-24 FI FI950309A patent/FI950309A/fi unknown
- 1995-01-25 NZ NZ270395A patent/NZ270395A/en not_active IP Right Cessation
- 1995-01-26 HU HU9500240A patent/HUT72062A/hu unknown
- 1995-01-26 ES ES95101059T patent/ES2182852T3/es not_active Expired - Lifetime
- 1995-01-26 AT AT95101059T patent/ATE223378T1/de not_active IP Right Cessation
- 1995-01-26 RU RU95101048/04A patent/RU95101048A/ru unknown
- 1995-01-26 ZA ZA95631A patent/ZA95631B/xx unknown
- 1995-01-26 EP EP95101059A patent/EP0669317B1/en not_active Expired - Lifetime
- 1995-01-26 NO NO950297A patent/NO950297L/no unknown
- 1995-01-26 US US08/378,615 patent/US5744487A/en not_active Expired - Lifetime
- 1995-01-26 DE DE69528005T patent/DE69528005T2/de not_active Expired - Lifetime
- 1995-01-27 CN CN95100042A patent/CN1066712C/zh not_active Expired - Fee Related
- 1995-01-27 KR KR1019950001519A patent/KR950032114A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0669317A1 (en) | 1995-08-30 |
US5744487A (en) | 1998-04-28 |
RU95101048A (ru) | 1996-10-27 |
CA2140598C (en) | 2010-03-09 |
ATE223378T1 (de) | 2002-09-15 |
KR950032114A (ko) | 1995-12-20 |
DE69528005D1 (de) | 2002-10-10 |
NO950297D0 (no) | 1995-01-26 |
HUT72062A (en) | 1996-03-28 |
DE69528005T2 (de) | 2003-04-17 |
ZA95631B (en) | 1995-10-05 |
FI950309A (fi) | 1995-07-28 |
AU1025795A (en) | 1995-08-03 |
TW306917B (es) | 1997-06-01 |
HU9500240D0 (en) | 1995-03-28 |
EP0669317B1 (en) | 2002-09-04 |
CN1121068A (zh) | 1996-04-24 |
CN1066712C (zh) | 2001-06-06 |
FI950309A0 (fi) | 1995-01-24 |
NZ270395A (en) | 1997-06-24 |
CA2140598A1 (en) | 1995-07-28 |
NO950297L (no) | 1995-07-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2182852T3 (es) | Derivados de prolinamida. | |
TR200200579T2 (tr) | Amino-tirazolpiridin türevleri. | |
DK0976748T3 (da) | Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet | |
ATE297203T1 (de) | Antithrombotische mitteln | |
ES2149186T3 (es) | Derivados de dihidrochalcona hipoglicemicos. | |
DK0889875T3 (da) | Cycloproylalkansyrederivater | |
DE69834500D1 (de) | Xanthinderivative zur behandlung von hirnischämie | |
IL136100A (en) | Biphenylamidine derivatives and pharmaceutical compositions containing the same | |
MD1560F2 (en) | Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses. | |
DE69931378D1 (de) | Chinazolin derivate und therapeutische verwendungen davon | |
NO983444L (no) | Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer | |
EP0842663A4 (en) | OPHTHALMIC PREPARATIONS | |
PT855398E (pt) | Derivados sasquiterpeno tendo actividade antiviral | |
DE69600231D1 (de) | N-Arylalkylphenylacetamidderivate | |
NO964497L (no) | Middel for behandling av cor pulmonale | |
EP1210948B8 (en) | Therapeutic peptide for nervous diseases |