NZ538572A - Non-covalent inhibitors of urokinase and blood vessel formation - Google Patents

Non-covalent inhibitors of urokinase and blood vessel formation

Info

Publication number
NZ538572A
NZ538572A NZ538572A NZ53857201A NZ538572A NZ 538572 A NZ538572 A NZ 538572A NZ 538572 A NZ538572 A NZ 538572A NZ 53857201 A NZ53857201 A NZ 53857201A NZ 538572 A NZ538572 A NZ 538572A
Authority
NZ
New Zealand
Prior art keywords
urokinase
non
blood vessel
vessel formation
covalent inhibitors
Prior art date
Application number
NZ538572A
Inventor
Odile Esther Levy
Edwin L Madison
Joseph Edward Semple
Amir P Tamiz
Michael I Weinhouse
Original Assignee
Dendreon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US63748300A priority Critical
Priority to EP20000126874 priority patent/EP1182207B1/en
Priority to US09/733,645 priority patent/US6586405B2/en
Application filed by Dendreon Corp filed Critical Dendreon Corp
Priority to NZ51819501A priority patent/NZ518195A/en
Priority to NZ538572A priority patent/NZ538572A/en
Publication of NZ538572A publication Critical patent/NZ538572A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069Ser-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

Disclosed are selected compounds from general formula (I), such as the compound of formula (II). The compounds are used in the manufacture of medicaments for the treatment of conditions ameliorated by inhibiting or decreasing urokinase activity, angiogenesis in a mammal.
NZ538572A 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation NZ538572A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US63748300A true 2000-08-11 2000-08-11
EP20000126874 EP1182207B1 (en) 2000-08-11 2000-12-07 Non-covalent inhibitors of urokinase and blood vessel formation
US09/733,645 US6586405B2 (en) 2000-08-11 2000-12-07 Non-covalent inhibitors of urokinase and blood vessel formation
NZ51819501A NZ518195A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation
NZ538572A NZ538572A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ547626A NZ547626A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation
NZ538572A NZ538572A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation

Publications (1)

Publication Number Publication Date
NZ538572A true NZ538572A (en) 2006-09-29

Family

ID=27223185

Family Applications (3)

Application Number Title Priority Date Filing Date
NZ538572A NZ538572A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation
NZ51819501A NZ518195A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation
NZ547626A NZ547626A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation

Family Applications After (2)

Application Number Title Priority Date Filing Date
NZ51819501A NZ518195A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation
NZ547626A NZ547626A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation

Country Status (6)

Country Link
JP (1) JP2004506648A (en)
AU (2) AU785260B2 (en)
CA (1) CA2387002A1 (en)
IL (1) IL149042D0 (en)
NZ (3) NZ538572A (en)
WO (1) WO2002014349A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062829A1 (en) * 2001-02-02 2002-08-15 Chugai Seiyaku Kabushiki Kaisha Peptide derivatives
AU2002364713A1 (en) * 2001-12-04 2003-06-17 Corvas International, Inc. Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
WO2003053999A2 (en) * 2001-12-12 2003-07-03 Wilex Ag Selective arylguanidine peptides as urokinase inhibitors
DE50310038D1 (en) 2002-03-11 2008-08-07 Curacyte Ag Ingredients of urokinase, their preparation and use
DE10301300B4 (en) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Use of acylated 4-amidino- and 4-guanidinobenzylamines for the inhibition of plasma kallikrein
DE10323898A1 (en) 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors
DE10342108A1 (en) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basic substituted benzylamine analogs as coagulation factor Xa inhibitors, their preparation and use
KR20080027875A (en) 2005-06-24 2008-03-28 빌렉스 아게 Use of urokinase inhibitors for the treatment and/or prevention of neuropathological diseases
CN101378744A (en) * 2005-08-29 2009-03-04 威丽克斯股份公司 Oxadiazole compounds as urokinase inhibitors
DE102005044319A1 (en) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2- (Aminomethyl) -5-chloro-benzylamide derivatives and their use as inhibitors of coagulation factor Xa
DE102006050672A1 (en) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh New glycylglycine derivatives with a benzylsulfonylamido group and an amidino-organylamido group at the opposite chain ends, used in drugs for reducing loss of blood, e.g. in operations
GB0807828D0 (en) * 2008-04-29 2008-06-04 Vantia Ltd Aminopyridine derivatives
US8921319B2 (en) 2010-07-07 2014-12-30 The Medicines Company (Leipzig) Gmbh Serine protease inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
CA2140598C (en) * 1994-01-27 2010-03-09 Masahiro Ohshima Prolineamide derivatives
DE4443390A1 (en) * 1994-12-06 1996-06-13 Basf Ag New dipeptide p-Amidinobenzylamide with N-terminal sulfonyl or Aminosulfonylresten
CZ237697A3 (en) * 1995-02-10 1998-04-15 Basf Aktiengesellschaft Derivative of peptidic p-amidinobenzylamide as thrombin inhibitor and intermediates for preparing thereof
US6576613B1 (en) * 1998-07-24 2003-06-10 Corvas International, Inc. Title inhibitors of urokinase
CZ20013577A3 (en) * 1999-04-09 2002-07-17 Basf Aktiengesellschaft Inhibitors of complement proteases with low molecular weight
DE10029014A1 (en) * 2000-06-15 2001-12-20 Univ Schiller Jena Urokinase inhibitor, useful for treatment, prophylaxis or diagnosis of thromboembolic disease, comprising acylated 3- or 4-amidino-benzylamine derivative
DE10029015A1 (en) * 2000-06-15 2001-12-20 Curacyte Ag Coagulation Factor Xa inhibitor, useful for treatment, prophylaxis or diagnosis of thromboembolic disease, comprising acylated 3- or 4-amidino-benzylamine derivative

Also Published As

Publication number Publication date
AU2006235835B2 (en) 2009-06-25
CA2387002A1 (en) 2002-02-21
JP2004506648A (en) 2004-03-04
AU2006235835A1 (en) 2006-11-30
IL149042D0 (en) 2002-11-10
AU8334701A (en) 2002-02-25
AU785260B2 (en) 2006-12-07
WO2002014349A3 (en) 2002-10-03
NZ518195A (en) 2005-04-29
WO2002014349A2 (en) 2002-02-21
NZ547626A (en) 2007-10-26

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Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: DENDREON SAN DIEGO LLC, US

Free format text: OLD OWNER(S): DENDREON CORPORATION

Owner name: DENDREON SAN DIEGO LLC, US

Free format text: OLD OWNER(S): DENDREON SAN DIEGO LLC; CORVAS INTERNATIONAL, INC.

ASS Change of ownership

Owner name: DENDREON CORPORATION, US

Free format text: OLD OWNER(S): DENDREON SAN DIEGO LLC

PSEA Patent sealed
RENW Renewal (renewal fees accepted)
ASS Change of ownership

Owner name: WILEX AG, DE

Free format text: OLD OWNER(S): DENDREON CORPORATION

RENW Renewal (renewal fees accepted)