AR035216A1 - Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios - Google Patents

Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios

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Publication number
AR035216A1
AR035216A1 ARP010105543A ARP010105543A AR035216A1 AR 035216 A1 AR035216 A1 AR 035216A1 AR P010105543 A ARP010105543 A AR P010105543A AR P010105543 A ARP010105543 A AR P010105543A AR 035216 A1 AR035216 A1 AR 035216A1
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Argentina
Prior art keywords
derivatives
pharmaceutically acceptable
medicines
manufacture
processes
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ARP010105543A
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English (en)
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Astrazeneca Ab
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Publication date
Priority claimed from SE0004458A external-priority patent/SE0004458D0/xx
Priority claimed from SE0100965A external-priority patent/SE0100965D0/xx
Priority claimed from SE0101239A external-priority patent/SE0101239D0/xx
Priority claimed from SE0102921A external-priority patent/SE0102921D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR035216A1 publication Critical patent/AR035216A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
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    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
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    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C07C59/50—Mandelic acid
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    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Derivados de ácido mandélico que tiene la fórmula (1) en donde Ra representa -OH o CH2OH; R1 representa uno o más sustituyentes halo opcionales; R2 representa uno o dos sustituyentes alcoxi C1-3, cuyas partes alquilo están sustituidas entre sí con uno más sustituyentes flúor; Y representa -CH2- o -(CH2)2-; y R3 representa un fragmento estructural de fórmulas (2) o (3): en donde R4 representa H o uno o más sustituyentes flúor; y uno o dos de X1, X2, X3, y X4 representa -N- y los otros representan -CH-, o un derivado farmacéuticamente aceptable del mismo; y derivados farmacéuticamente aceptables (incluyendo profármacos) del mismo, que son útiles como, o son útiles como profármacos de, inhibidores selectivos de proteasas del tipo tripsina, tales como trombina, y por lo tanto, en particular, en el tratamiento de condiciones donde se requiere la inhibición de la trombina (por ejemplo, trombosis), o como anticoagulantes. Usos de estos derivados para la fabricación de medicamentos, métodos de tratamiento, procesos para la preparación de esto derivados y compuestos intermediarios.
ARP010105543A 2000-12-01 2001-11-28 Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios AR035216A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0004458A SE0004458D0 (sv) 2000-12-01 2000-12-01 Pharmaceutically useful compounds
SE0100965A SE0100965D0 (sv) 2001-03-19 2001-03-19 Pharmaceutically-useful compounds
SE0101239A SE0101239D0 (sv) 2001-04-06 2001-04-06 Pharmaceutically useful compounds
SE0102921A SE0102921D0 (sv) 2001-08-30 2001-08-30 Pharmaceutically useful compounds

Publications (1)

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AR035216A1 true AR035216A1 (es) 2004-05-05

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Family Applications (2)

Application Number Title Priority Date Filing Date
ARP010105543A AR035216A1 (es) 2000-12-01 2001-11-28 Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
ARP090102945A AR072331A2 (es) 2000-12-01 2009-07-31 Derivados de acido mandelico, formulacion farmaceutica, procesos para la preparacion de estos derivados, y compuestos intermediarios

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Application Number Title Priority Date Filing Date
ARP090102945A AR072331A2 (es) 2000-12-01 2009-07-31 Derivados de acido mandelico, formulacion farmaceutica, procesos para la preparacion de estos derivados, y compuestos intermediarios

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US (4) US20070218136A1 (es)
EP (2) EP2186800A1 (es)
JP (3) JP4177101B2 (es)
KR (4) KR100947296B1 (es)
CN (1) CN1291975C (es)
AR (2) AR035216A1 (es)
AT (1) ATE461171T1 (es)
AU (2) AU2007203509A1 (es)
BG (1) BG66261B1 (es)
BR (1) BR0115861A (es)
CA (1) CA2436220C (es)
CY (1) CY1113487T1 (es)
CZ (1) CZ303708B6 (es)
DE (1) DE60141603D1 (es)
DK (1) DK1347955T3 (es)
EE (1) EE05382B1 (es)
ES (1) ES2341318T3 (es)
HK (1) HK1057214A1 (es)
HU (1) HU228814B1 (es)
IL (1) IL156096A0 (es)
IS (1) IS2755B (es)
MX (1) MXPA03004794A (es)
MY (1) MY136133A (es)
NO (3) NO325228B1 (es)
NZ (1) NZ526205A (es)
PL (1) PL207045B1 (es)
PT (1) PT1347955E (es)
SI (1) SI1347955T1 (es)
SK (1) SK287692B6 (es)
WO (1) WO2002044145A1 (es)

Families Citing this family (53)

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Publication number Priority date Publication date Assignee Title
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201658D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Immediate release pharmaceutical formulation
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
MXPA05008600A (es) 2003-02-13 2005-11-04 Wellstat Therapeutics Corp Compuestos para el tratamiento de desordenes metabolicos.
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