AR005245A1 - Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion - Google Patents
Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacionInfo
- Publication number
- AR005245A1 AR005245A1 ARP960105567A ARP960105567A AR005245A1 AR 005245 A1 AR005245 A1 AR 005245A1 AR P960105567 A ARP960105567 A AR P960105567A AR P960105567 A ARP960105567 A AR P960105567A AR 005245 A1 AR005245 A1 AR 005245A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- optionally substituted
- prodroges
- naphthyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Prodrogas de inhibidores de trombina, que comprenden la fórmula (I): RaOCC-CH2-(R)Cgl-Aze-Pab-Hdonde R1 es -R3 o -A1C(O)N(R4)R5 o -A1C(O)(R4); A1 es alquileno de C1-5; R2 (que reemplaza uno de los átomos de hidrógeno en la unidad amidino d e Pab- H esOH, OC(O)R6,C(O)OR7 o C(O)OCH(R8)OC(O)R9; R3 es H, alquilo C1-10, o alquilfenilo C1-3 (estando este último grupo opcionalmente substituido conalquilo C1-6, alcoxi C1-6, nitro o halógeno); R4-R5 son independientemente H, alquil o C1-6, fenilo, 2- naftilo o, cuando R1 es A1C(O)N(R4)R5, conjuntamentecon el átomo de nitrógeno al cual están unidos son pirrolidinilo o piperidinilo; R6 es alquilo C1-17, fenilo o 2-naftilo (todos los cuales estánopcionalmente substitui dos con alquilo C1-6, alcoxiC1-6, nitro o halógeno); R7 es 2-naftilo, fenilo, alquilfenilo C1-3 (cuyos últimos tres grupos estánopcionalmente substituidos con alquilo C1-6, alcoxi C1-6, nitro o halógeno)o alquilo C1-12 (cuyo último grupo está opc ionalmente substituido conalcoxiC1-6, aciloxi C1-6 o halógeno); R8 es H o alquilo C1-4; y R9 es 2-naftilo, fenilo, alcoxi C1-6 o alquilo C1-8 (cuyo último grupo está opcionalmentesubstituido con halógeno, alcoxi C1-6 o aciloxi C1-6); con la con dición de que cuando R1 esR3; R3 es bencilo, metilo, etilo, n-butilo o n-hexilo y R2 esC(O)OR7, entonces R7 no es bencilo; o una sal farmacéuticamente aceptable del mismo; donde Cgl es ciclohexilglicina; Aze significa ácido S-azetidina-2-carboxíl ico y Pab significa unradical bivalente derivado de 1-amidino-4- aminometilbenceno; una formulación farmacéutica que los comprende, el uso dedichas drogas para la manufactura de un medicamento y un procedimiento para su preparación.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9526273A GB9526273D0 (en) | 1995-12-21 | 1995-12-21 | New prodrugs |
SE9600556A SE9600556D0 (sv) | 1996-02-15 | 1996-02-15 | New prodrugs |
Publications (1)
Publication Number | Publication Date |
---|---|
AR005245A1 true AR005245A1 (es) | 1999-04-28 |
Family
ID=26308368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960105567A AR005245A1 (es) | 1995-12-21 | 1996-12-09 | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
Country Status (30)
Country | Link |
---|---|
US (4) | US5965692A (es) |
EP (3) | EP0869966B1 (es) |
JP (1) | JP2000504313A (es) |
KR (1) | KR100458545B1 (es) |
AR (1) | AR005245A1 (es) |
AT (2) | ATE291031T1 (es) |
BR (1) | BR9612148A (es) |
CA (1) | CA2238737A1 (es) |
DE (3) | DE122004000046I2 (es) |
DK (2) | DK0869966T3 (es) |
EE (1) | EE04022B1 (es) |
ES (2) | ES2128283T3 (es) |
HK (2) | HK1016610A1 (es) |
HU (1) | HUP9900115A3 (es) |
IL (1) | IL124857A0 (es) |
IS (1) | IS1836B (es) |
LU (1) | LU91172I2 (es) |
MX (1) | MX9804623A (es) |
MY (1) | MY121222A (es) |
NL (1) | NL300179I2 (es) |
NO (1) | NO982809L (es) |
NZ (2) | NZ324902A (es) |
PL (1) | PL187468B1 (es) |
PT (1) | PT995755E (es) |
RU (1) | RU2176644C2 (es) |
SI (2) | SI0995755T1 (es) |
SK (1) | SK285588B6 (es) |
TR (1) | TR199801151T2 (es) |
TW (2) | TW541316B (es) |
WO (1) | WO1997023499A1 (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US6984627B1 (en) * | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
AR005245A1 (es) * | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
IL139162A0 (en) | 1998-04-24 | 2001-11-25 | Dimensional Pharm Inc | Amidinohydrazone, alkoxyguanidine and aminoguanidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
US6274090B1 (en) * | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
SE9802938D0 (sv) | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
SE9802974D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
SE9802973D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
TR200102037T2 (tr) | 1999-01-13 | 2001-10-22 | Astrazeneca Ab | Yeni amidinobenzilamin türevleri ve trombin engelleyiciler olarak kullanılmaları. |
SE9900070D0 (sv) | 1999-01-13 | 1999-01-13 | Astra Ab | New use |
SK14232001A3 (sk) | 1999-04-09 | 2002-06-04 | Basf Aktiengesellschaft | Nízkomolekulové inhibítory komplementárnych proteáz |
CN1355810A (zh) | 1999-04-09 | 2002-06-26 | 巴斯福股份公司 | 凝血酶抑制剂的前体药物 |
AR023510A1 (es) * | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
SE9902550D0 (sv) * | 1999-07-02 | 1999-07-02 | Astra Ab | New crystalline forms |
JP2003504329A (ja) | 1999-07-08 | 2003-02-04 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 抗微生物アミジンの新規プロドラッグ |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
US6462021B1 (en) | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
SE0101762D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | New use |
SE0101932D0 (sv) * | 2001-05-31 | 2001-05-31 | Astrazeneca Ab | Pharmaceutical combinations |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
GB0123851D0 (en) * | 2001-10-04 | 2001-11-28 | Pankhurst Design & Development | Dispersing fragrances |
SE0103369D0 (sv) * | 2001-10-09 | 2001-10-09 | Astrazeneca Ab | Pharmaceutical formulation |
SE0103590D0 (sv) | 2001-10-26 | 2001-10-26 | Astrazeneca Ab | New Combination |
SE0200198D0 (sv) | 2002-01-23 | 2002-01-23 | Astrazeneca Ab | New use |
ATE399175T1 (de) | 2002-03-11 | 2008-07-15 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
AU2003221926A1 (en) * | 2002-04-10 | 2003-10-27 | Esperion Therapeutics, Inc. | Mimics of acyl coenzyme-a comprising pantolactone and pantothenic acid derivatives, compositions thereof, and methods of cholesterol management and related uses |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
SE0301879D0 (sv) * | 2003-06-25 | 2003-06-25 | Astrazeneca Ab | New process |
JP4738333B2 (ja) * | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | 9−アミノメチルテトラサイクリン化合物のプロドラッグ |
DE10342108A1 (de) | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
PE20060594A1 (es) * | 2004-09-09 | 2006-08-18 | Novartis Ag | Composicion farmaceutica que contiene un agonista de ppar |
US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
DE102009004204A1 (de) * | 2009-01-09 | 2010-07-15 | Christian-Albrechts-Universität Zu Kiel | Verfahren zur verbesserten Bioaktivierung von Arzneistoffen |
DE102009008256A1 (de) | 2009-02-10 | 2010-08-12 | Lts Lohmann Therapie-Systeme Ag | Prodrugs vom Typ N-hydroxylierter Amidine, Guanidine und/oder Aminohydrazone zur Applikation über die Haut |
DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU178398B (en) * | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
US4568636A (en) * | 1981-03-25 | 1986-02-04 | Pentapharm Ag | Tripeptide derivatives |
US4395401A (en) * | 1981-09-09 | 1983-07-26 | Smithkline Beckman Corporation | Renally active dipeptides |
HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
ZA86746B (en) * | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
DE3505555A1 (de) * | 1985-02-18 | 1986-09-11 | Behringwerke Ag, 3550 Marburg | Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel |
PT84170B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas |
DE3606480A1 (de) * | 1986-02-28 | 1987-09-03 | Behringwerke Ag | Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung |
US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
EP0362002B1 (en) * | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
ZA897514B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
US5273982A (en) * | 1990-03-09 | 1993-12-28 | Hoffmann-La Roche Inc. | Acetic acid derivatives |
US5037819A (en) * | 1990-06-04 | 1991-08-06 | Bristol-Myers Squibb Company | Azetidin-2-one derivatives as serine protease inhibitors |
US5110812A (en) * | 1990-06-04 | 1992-05-05 | Bristol-Myers Squibb Co. | Azetidin-2-one derivatives as serine protease inhibitors |
TW201303B (es) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
GB9017694D0 (en) * | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
GB9019558D0 (en) * | 1990-09-07 | 1990-10-24 | Szelke Michael | Enzyme inhibitors |
IL99527A (en) * | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
AU8868991A (en) * | 1990-11-15 | 1992-06-11 | Pentapharm Ag | Meta-substituted phenyl alanine derivatives |
DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
CZ333492A3 (en) * | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
US5760235A (en) * | 1992-03-04 | 1998-06-02 | Gyogyszerkutato Intezet Kft. | Anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for preparation thereof |
TW223629B (es) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
AU675981B2 (en) * | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
DE4321444A1 (de) * | 1993-06-28 | 1995-01-05 | Bernd Prof Dr Clement | Pharmazeutische Zubereitung |
EP0648780A1 (en) * | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
TW394760B (en) * | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
CA2140598C (en) * | 1994-01-27 | 2010-03-09 | Masahiro Ohshima | Prolineamide derivatives |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
US5561146A (en) * | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
SE504185C2 (sv) * | 1994-11-08 | 1996-12-02 | Astra Ab | Lagringsstabil vattenlösning för infusion av trombininhibitorer |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
MX9706069A (es) * | 1995-02-17 | 1997-10-31 | Basf Ag | Nuevos inhibidores de la trombina. |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
AU698911B2 (en) * | 1995-04-04 | 1998-11-12 | Merck & Co., Inc. | Thrombin inhibitors |
US5629324A (en) * | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
AR005245A1 (es) * | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
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1996
- 1996-12-09 AR ARP960105567A patent/AR005245A1/es active IP Right Grant
- 1996-12-09 TW TW085115209A patent/TW541316B/zh active
- 1996-12-09 TW TW091115525A patent/TWI238827B/zh active
- 1996-12-17 PT PT99120315T patent/PT995755E/pt unknown
- 1996-12-17 DE DE122004000046C patent/DE122004000046I2/de active Active
- 1996-12-17 EP EP96943446A patent/EP0869966B1/en not_active Expired - Lifetime
- 1996-12-17 US US08/776,231 patent/US5965692A/en not_active Expired - Lifetime
- 1996-12-17 IL IL12485796A patent/IL124857A0/xx unknown
- 1996-12-17 AT AT96943446T patent/ATE291031T1/de active
- 1996-12-17 KR KR10-1998-0704728A patent/KR100458545B1/ko not_active IP Right Cessation
- 1996-12-17 EP EP99120315A patent/EP0995755B1/en not_active Expired - Lifetime
- 1996-12-17 ES ES96943446T patent/ES2128283T3/es not_active Expired - Lifetime
- 1996-12-17 SK SK821-98A patent/SK285588B6/sk not_active IP Right Cessation
- 1996-12-17 BR BR9612148A patent/BR9612148A/pt active Search and Examination
- 1996-12-17 EP EP05000116A patent/EP1533318A1/en not_active Withdrawn
- 1996-12-17 TR TR1998/01151T patent/TR199801151T2/xx unknown
- 1996-12-17 PL PL96327569A patent/PL187468B1/pl not_active IP Right Cessation
- 1996-12-17 SI SI9630364T patent/SI0995755T1/xx unknown
- 1996-12-17 SI SI9630712T patent/SI0869966T1/xx unknown
- 1996-12-17 JP JP9523571A patent/JP2000504313A/ja active Pending
- 1996-12-17 DK DK96943446T patent/DK0869966T3/da active
- 1996-12-17 EE EE9800187A patent/EE04022B1/xx not_active IP Right Cessation
- 1996-12-17 RU RU98111148/04A patent/RU2176644C2/ru not_active IP Right Cessation
- 1996-12-17 ES ES99120315T patent/ES2163916T3/es not_active Expired - Lifetime
- 1996-12-17 CA CA002238737A patent/CA2238737A1/en not_active Abandoned
- 1996-12-17 HU HU9900115A patent/HUP9900115A3/hu unknown
- 1996-12-17 NZ NZ324902A patent/NZ324902A/en not_active IP Right Cessation
- 1996-12-17 WO PCT/SE1996/001680 patent/WO1997023499A1/en active IP Right Grant
- 1996-12-17 DE DE69634492T patent/DE69634492T2/de not_active Expired - Lifetime
- 1996-12-17 DK DK99120315T patent/DK0995755T3/da active
- 1996-12-17 DE DE69614579T patent/DE69614579T2/de not_active Expired - Lifetime
- 1996-12-17 AT AT99120315T patent/ATE204292T1/de active
- 1996-12-17 NZ NZ504245A patent/NZ504245A/en not_active IP Right Cessation
- 1996-12-19 MY MYPI96005362A patent/MY121222A/en unknown
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1998
- 1998-05-26 IS IS4756A patent/IS1836B/is unknown
- 1998-06-09 MX MX9804623A patent/MX9804623A/es not_active IP Right Cessation
- 1998-06-18 NO NO982809A patent/NO982809L/no not_active Application Discontinuation
-
1999
- 1999-04-09 HK HK99101429A patent/HK1016610A1/xx not_active IP Right Cessation
- 1999-07-15 US US09/353,644 patent/US6262028B1/en not_active Expired - Fee Related
-
2000
- 2000-08-30 HK HK00105419A patent/HK1026214A1/xx not_active IP Right Cessation
-
2002
- 2002-02-14 US US10/074,008 patent/US20020142968A1/en not_active Abandoned
-
2004
- 2004-02-12 US US10/776,245 patent/US7354905B2/en not_active Expired - Fee Related
-
2005
- 2005-03-03 NL NL300179C patent/NL300179I2/nl unknown
- 2005-05-11 LU LU91172C patent/LU91172I2/fr unknown
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