NL300179I1 - Geneesmiddelvoorlopers van trombineremmers. - Google Patents

Geneesmiddelvoorlopers van trombineremmers.

Info

Publication number
NL300179I1
NL300179I1 NL300179C NL300179C NL300179I1 NL 300179 I1 NL300179 I1 NL 300179I1 NL 300179 C NL300179 C NL 300179C NL 300179 C NL300179 C NL 300179C NL 300179 I1 NL300179 I1 NL 300179I1
Authority
NL
Netherlands
Prior art keywords
thrombin inhibitors
drug precursors
precursors
drug
thrombin
Prior art date
Application number
NL300179C
Other languages
English (en)
Other versions
NL300179I2 (nl
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9526273A external-priority patent/GB9526273D0/en
Priority claimed from SE9600556A external-priority patent/SE9600556D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NL300179I1 publication Critical patent/NL300179I1/nl
Publication of NL300179I2 publication Critical patent/NL300179I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NL300179C 1995-12-21 2005-03-03 Geneesmiddelvoorlopers van trombineremmers. NL300179I2 (nl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9526273A GB9526273D0 (en) 1995-12-21 1995-12-21 New prodrugs
SE9600556A SE9600556D0 (sv) 1996-02-15 1996-02-15 New prodrugs
EP96943446A EP0869966B1 (en) 1995-12-21 1996-12-17 Prodrugs of thrombin inhibitors

Publications (2)

Publication Number Publication Date
NL300179I1 true NL300179I1 (nl) 2005-05-02
NL300179I2 NL300179I2 (nl) 2005-06-01

Family

ID=26308368

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300179C NL300179I2 (nl) 1995-12-21 2005-03-03 Geneesmiddelvoorlopers van trombineremmers.

Country Status (30)

Country Link
US (4) US5965692A (nl)
EP (3) EP0869966B1 (nl)
JP (1) JP2000504313A (nl)
KR (1) KR100458545B1 (nl)
AR (1) AR005245A1 (nl)
AT (2) ATE291031T1 (nl)
BR (1) BR9612148A (nl)
CA (1) CA2238737A1 (nl)
DE (3) DE122004000046I2 (nl)
DK (2) DK0869966T3 (nl)
EE (1) EE04022B1 (nl)
ES (2) ES2128283T3 (nl)
HK (2) HK1016610A1 (nl)
HU (1) HUP9900115A3 (nl)
IL (1) IL124857A0 (nl)
IS (1) IS1836B (nl)
LU (1) LU91172I2 (nl)
MX (1) MX9804623A (nl)
MY (1) MY121222A (nl)
NL (1) NL300179I2 (nl)
NO (1) NO982809L (nl)
NZ (2) NZ504245A (nl)
PL (1) PL187468B1 (nl)
PT (1) PT995755E (nl)
RU (1) RU2176644C2 (nl)
SI (2) SI0995755T1 (nl)
SK (1) SK285588B6 (nl)
TR (1) TR199801151T2 (nl)
TW (2) TW541316B (nl)
WO (1) WO1997023499A1 (nl)

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SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9802974D0 (sv) 1998-09-03 1998-09-03 Astra Ab New crystalline forms
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
EP1150996B1 (en) 1999-01-13 2007-11-21 AstraZeneca AB New amidinobenzylamine derivatives and their use as thrombin inhibitors
SE9900070D0 (sv) 1999-01-13 1999-01-13 Astra Ab New use
JP4489976B2 (ja) 1999-04-09 2010-06-23 ビーエーエスエフ ソシエタス・ヨーロピア 補体プロテアーゼの低分子インヒビター
BR0009674A (pt) * 1999-04-09 2002-01-15 Basf Ag Composto, droga, e, uso de composto
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
SE9902550D0 (sv) * 1999-07-02 1999-07-02 Astra Ab New crystalline forms
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SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
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US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
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US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
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Also Published As

Publication number Publication date
NL300179I2 (nl) 2005-06-01
NZ324902A (en) 2000-06-23
DE69614579D1 (de) 2001-09-20
DK0869966T3 (da) 2005-06-20
EP1533318A1 (en) 2005-05-25
HK1026214A1 (en) 2000-12-08
WO1997023499A1 (en) 1997-07-03
DE69614579T2 (de) 2002-06-27
KR19990076624A (ko) 1999-10-15
PL187468B1 (pl) 2004-07-30
US20020142968A1 (en) 2002-10-03
ATE291031T1 (de) 2005-04-15
ES2163916T3 (es) 2002-02-01
RU2176644C2 (ru) 2001-12-10
AR005245A1 (es) 1999-04-28
NO982809D0 (no) 1998-06-18
US6262028B1 (en) 2001-07-17
PL327569A1 (en) 1998-12-21
TW541316B (en) 2003-07-11
CA2238737A1 (en) 1997-07-03
MY121222A (en) 2006-01-28
EP0869966B1 (en) 2005-03-16
JP2000504313A (ja) 2000-04-11
AU706350B2 (en) 1999-06-17
EP0869966A1 (en) 1998-10-14
DK0995755T3 (da) 2001-11-12
EE9800187A (et) 1998-12-15
NZ504245A (en) 2004-11-26
ATE204292T1 (de) 2001-09-15
DE69634492T2 (de) 2006-04-13
US20040162410A1 (en) 2004-08-19
AU1217897A (en) 1997-07-17
SK82198A3 (en) 1998-12-02
IL124857A0 (en) 1999-01-26
DE69634492D1 (de) 2005-04-21
HUP9900115A3 (en) 1999-11-29
US7354905B2 (en) 2008-04-08
ES2128283T3 (es) 2005-09-01
BR9612148A (pt) 1999-07-13
NO982809L (no) 1998-08-20
SI0995755T1 (en) 2002-02-28
HK1016610A1 (en) 1999-11-05
DE122004000046I1 (de) 2005-04-21
ES2128283T1 (es) 1999-05-16
US5965692A (en) 1999-10-12
EE04022B1 (et) 2003-04-15
KR100458545B1 (ko) 2005-01-15
DE122004000046I2 (de) 2011-06-16
HUP9900115A2 (hu) 1999-05-28
EP0995755A1 (en) 2000-04-26
MX9804623A (es) 1998-10-31
IS4756A (is) 1998-05-26
EP0995755B1 (en) 2001-08-16
SK285588B6 (sk) 2007-04-05
LU91172I2 (fr) 2005-07-11
TWI238827B (en) 2005-09-01
IS1836B (is) 2002-11-25
SI0869966T1 (en) 2005-08-31
TR199801151T2 (xx) 1998-08-21
PT995755E (pt) 2002-02-28

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