BR9911300A - Composto, composição farmacêutica, e, uso do composto - Google Patents

Composto, composição farmacêutica, e, uso do composto

Info

Publication number
BR9911300A
BR9911300A BR9911300-7A BR9911300A BR9911300A BR 9911300 A BR9911300 A BR 9911300A BR 9911300 A BR9911300 A BR 9911300A BR 9911300 A BR9911300 A BR 9911300A
Authority
BR
Brazil
Prior art keywords
alkyl
compound
quinolinyl
iso
compounds
Prior art date
Application number
BR9911300-7A
Other languages
English (en)
Inventor
Johannes Egbertus Maria Basten
Constant Adriaan Anton Boeckel
Rogier Christian Buijsman
Cornelia Maria Dreef-Tromp
Original Assignee
Akzo Nobel Nv
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Univ Leiden filed Critical Akzo Nobel Nv
Publication of BR9911300A publication Critical patent/BR9911300A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, USO DO COMPOSTO" A presente invenção refere-se a compostos de fórmula (I), em que R^ 1^ é fenila, naftila, 1,2,3,4-tetraidronaftila, (iso)quinolinila, tetraidro(iso)quinolinila, 3,4-diidro-1H-isoquinolinila, cromanila ou o grupo cânfora, grupos que podem ser opcionalmente substituídos por um ou mais substituintes selecionados dentre (1-8C)alquila ou (1-8C)alcóxi; R^ 2^ e R^ 3^ são, independentemente, H ou (1-8C)alquila; R^ 4^ é (1-8C)alquila ou (3-8C)cicloalquila; ou R^ 3^ e R^ 4^ juntamente com o átomo de nitrogênio ao qual estão ligados são um anel não-aromático com 4-8 membros opcionalmente contendo outro heteroátomo, sendo que o anel é opcionalmente substituído por (1-8C)alquila ou SO~ 2~-(1-8C)alquila; Q é um espaçador com um comprimento de cadeia de 10 a 70 átomos; e Z é um radical de oligossacarídeo carregado negativamente compreendendo de duas a seis unidades de monossacarídeos, sendo que a carga é compensada por contra-íons carrregados positivamente; ou um seu sal farmaceuticamente aceitável ou uma pró-droga do mesmo. Os compostos da invenção apresentam atividade antitrombótica e podem ser usados no tratamento ou na prevenção de doenças relacionadas a trombina.
BR9911300-7A 1998-06-17 1999-06-11 Composto, composição farmacêutica, e, uso do composto BR9911300A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98202037 1998-06-17
PCT/EP1999/004100 WO1999065934A1 (en) 1998-06-17 1999-06-11 Antithrombotic compounds

Publications (1)

Publication Number Publication Date
BR9911300A true BR9911300A (pt) 2001-04-03

Family

ID=8233825

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911300-7A BR9911300A (pt) 1998-06-17 1999-06-11 Composto, composição farmacêutica, e, uso do composto

Country Status (31)

Country Link
US (1) US6486129B1 (pt)
EP (1) EP1087992B1 (pt)
JP (1) JP4369052B2 (pt)
KR (1) KR100790910B1 (pt)
CN (1) CN1261450C (pt)
AR (1) AR019674A1 (pt)
AT (1) ATE405580T1 (pt)
AU (1) AU756493B2 (pt)
BR (1) BR9911300A (pt)
CA (1) CA2334863C (pt)
CO (1) CO5080750A1 (pt)
CY (1) CY1108567T1 (pt)
CZ (1) CZ299382B6 (pt)
DE (1) DE69939378D1 (pt)
DK (1) DK1087992T3 (pt)
ES (1) ES2312210T3 (pt)
HK (1) HK1034266A1 (pt)
HU (1) HU229088B1 (pt)
ID (1) ID26614A (pt)
IL (2) IL139955A0 (pt)
NO (1) NO326057B1 (pt)
NZ (1) NZ508623A (pt)
PE (1) PE20000700A1 (pt)
PL (1) PL199433B1 (pt)
PT (1) PT1087992E (pt)
RU (1) RU2225869C2 (pt)
SK (1) SK286755B6 (pt)
TR (1) TR200003710T2 (pt)
TW (1) TWI221156B (pt)
WO (1) WO1999065934A1 (pt)
ZA (1) ZA200007075B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ299382B6 (cs) * 1998-06-17 2008-07-09 N.V. Organon Antitrombotické látky
TWI289566B (en) 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
JP2005525325A (ja) * 2002-01-31 2005-08-25 モルフォケム アクチェンゲゼルシャフト フュア コンビナトリシェ ヘミー Ｘａ因子活性を阻害する化合物
DE10300049A1 (de) * 2003-01-03 2004-07-15 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Faktor VIIa inhibieren
DE10330900B4 (de) * 2003-07-01 2006-09-14 Leibniz-Institut Für Polymerforschung Dresden E.V. Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt
EP1574516A1 (en) * 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotic compound
TW200621794A (en) * 2004-10-06 2006-07-01 Akzo Nobel Nv Pulmonary administration of an antithrombotic compound
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
JP2009511544A (ja) * 2005-10-10 2009-03-19 ナームローゼ・フエンノートチヤツプ・オルガノン 抗血栓化合物
US8183228B2 (en) * 2005-10-10 2012-05-22 MSD OSS B.V. Netherlands Anticoagulant antithrombotic dual inhibitors comprising a biotin label
CN102256990B (zh) * 2008-10-03 2014-09-24 聚糖生物科学有限责任公司 阴离子寡糖轭合物
JP2022538674A (ja) 2019-07-01 2022-09-05 トニックス ファーマ リミテッド 抗ｃｄ１５４抗体およびその使用
EP4274587A1 (en) 2021-01-06 2023-11-15 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT84170B (pt) 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
DE4115468A1 (de) 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
NZ264340A (en) * 1993-09-01 1995-04-27 Akzo Nobel Nv Bisconjugate comprising two saccharides and a spacer, use in pharmaceutical compositions
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
CZ299382B6 (cs) * 1998-06-17 2008-07-09 N.V. Organon Antitrombotické látky

Also Published As

Publication number Publication date
TR200003710T2 (tr) 2001-04-20
HUP0102764A3 (en) 2003-11-28
ZA200007075B (en) 2002-02-28
ID26614A (id) 2001-01-25
NO20006317L (no) 2001-02-14
CY1108567T1 (el) 2014-04-09
DK1087992T3 (da) 2008-11-24
NO20006317D0 (no) 2000-12-12
PL345238A1 (en) 2001-12-03
SK286755B6 (sk) 2009-05-07
IL139955A (en) 2006-08-20
ES2312210T3 (es) 2009-02-16
KR20010052943A (ko) 2001-06-25
JP2002518407A (ja) 2002-06-25
PL199433B1 (pl) 2008-09-30
CZ20004735A3 (cs) 2001-08-15
TWI221156B (en) 2004-09-21
CA2334863C (en) 2011-02-15
KR100790910B1 (ko) 2008-01-03
CN1261450C (zh) 2006-06-28
EP1087992B1 (en) 2008-08-20
NZ508623A (en) 2002-11-26
RU2225869C2 (ru) 2004-03-20
CN1305494A (zh) 2001-07-25
PE20000700A1 (es) 2000-08-14
CZ299382B6 (cs) 2008-07-09
JP4369052B2 (ja) 2009-11-18
WO1999065934A1 (en) 1999-12-23
CA2334863A1 (en) 1999-12-23
AU756493B2 (en) 2003-01-16
DE69939378D1 (de) 2008-10-02
AR019674A1 (es) 2002-03-13
HU229088B1 (en) 2013-07-29
CO5080750A1 (es) 2001-09-25
US6486129B1 (en) 2002-11-26
ATE405580T1 (de) 2008-09-15
HK1034266A1 (en) 2001-10-19
EP1087992A1 (en) 2001-04-04
AU4512999A (en) 2000-01-05
NO326057B1 (no) 2008-09-08
SK19222000A3 (sk) 2001-07-10
IL139955A0 (en) 2002-02-10
PT1087992E (pt) 2008-10-17
HUP0102764A2 (hu) 2001-12-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B25A Requested transfer of rights approved

Owner name: UNIVERSITY LEIDEN (NL) , MSD OSS B.V. (NL)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B25A Requested transfer of rights approved

Owner name: UNIVERSITY LEIDEN (NL) , ORGANON BIOSCIENCES NEDER

B25A Requested transfer of rights approved

Owner name: UNIVERSITY LEIDEN (NL) , MERCK SHARP AND DOHME B.V

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time