AR032607A1 - Composiciones farmaceuticas que contienen sales de hidroxieicosatetraenoato, y el uso de las mismas para la manufactura de un medicamento para el tratamiento de desordenes del ojo seco - Google Patents

Composiciones farmaceuticas que contienen sales de hidroxieicosatetraenoato, y el uso de las mismas para la manufactura de un medicamento para el tratamiento de desordenes del ojo seco

Info

Publication number
AR032607A1
AR032607A1 ARP000105865A ARP000105865A AR032607A1 AR 032607 A1 AR032607 A1 AR 032607A1 AR P000105865 A ARP000105865 A AR P000105865A AR P000105865 A ARP000105865 A AR P000105865A AR 032607 A1 AR032607 A1 AR 032607A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
treatment
dry eye
hydroxy
Prior art date
Application number
ARP000105865A
Other languages
English (en)
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AR032607A1 publication Critical patent/AR032607A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una composicion farmacéutica para el tratamiento del ojo seco, que comprende un derivado de HETE de acuerdo con las formulas (1), (2) o (3), en donde: X es OR o NHR', R es H o una porcion de sal farmacéuticamente aceptable cationica, alquilo sustituido o insustituido, cicloalquilo, (cicloalquil)alquilo, arilo, arilalquilo, en donde la sustitucion se hace con una porcion seleccionada entre el grupo que consiste de: alquilo, halogeno, hidroxi e hidroxi funcionalmente modificado; R' es H, alquilo sustituido o insustituido, cicloalquilo, (cicloalquil)alquilo, arilo, arilalquilo, en donde la sustitucion se hace con una porcion seleccionada entre el grupo que consiste de: alquilo, halogeno, hidroxi e hidroxi funcionalmente modificado; e Y es formulas (4), en donde R'' es H o C(O)R', el perfeccionamiento en donde el derivado de HETE es un derivado de HETE con estabilidad perfeccionada que tiene X = la porcion de sal farmacéuticamente aceptable O-M+; M+ es un cation farmacéuticamente aceptable seleccionado entre el grupo que consiste de: Na+, K+, Li+, Cs+, (A)4N+, y A es independientemente H, alquilo, cicloalquilo (cicloalquil)alquilo, alquil(cicloalquilo), arilo, arilalquilo, heteroarilo, o (A)4N+ forma una anillo heteroarilo, heterocicloalquenilo o heterocicloalquilo; composiciones farmacéuticas que contienen sales de hidroxieicosatetraenoato, y el uso de las mismas para la manufactura de un medicamento para el tratamiento de desordenes del ojo seco.
ARP000105865A 1999-11-09 2000-11-08 Composiciones farmaceuticas que contienen sales de hidroxieicosatetraenoato, y el uso de las mismas para la manufactura de un medicamento para el tratamiento de desordenes del ojo seco AR032607A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16438299P 1999-11-09 1999-11-09
US16438499P 1999-11-09 1999-11-09
US16437099P 1999-11-09 1999-11-09

Publications (1)

Publication Number Publication Date
AR032607A1 true AR032607A1 (es) 2003-11-19

Family

ID=27389012

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000105865A AR032607A1 (es) 1999-11-09 2000-11-08 Composiciones farmaceuticas que contienen sales de hidroxieicosatetraenoato, y el uso de las mismas para la manufactura de un medicamento para el tratamiento de desordenes del ojo seco

Country Status (20)

Country Link
US (1) US6429227B1 (es)
EP (1) EP1228028B1 (es)
JP (1) JP2003513949A (es)
KR (1) KR20020050240A (es)
CN (1) CN1387503A (es)
AR (1) AR032607A1 (es)
AT (1) ATE301630T1 (es)
AU (1) AU776187B2 (es)
BR (1) BR0015436A (es)
CA (1) CA2388044A1 (es)
DE (1) DE60021908T2 (es)
DK (1) DK1228028T3 (es)
ES (1) ES2242643T3 (es)
HK (1) HK1045302B (es)
MX (1) MXPA02004701A (es)
PL (1) PL356093A1 (es)
PT (1) PT1228028E (es)
TR (1) TR200201250T2 (es)
TW (1) TWI283176B (es)
WO (1) WO2001034549A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020077358A1 (en) * 2000-10-23 2002-06-20 Alcon Universal Ltd. Use of hydroperoxyeicosatetraenoic acid derivatives following refractive surgery
US20030109508A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
WO2003030892A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
EP1583527A1 (en) * 2002-06-14 2005-10-12 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
AU2003221715A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat vaginal dryness
US20030232858A1 (en) * 2002-06-14 2003-12-18 Barker Ronnie C. Use of hydroxyeicosatetraenoic acid compounds to treat dry mouth
AU2003221707A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
PL374700A1 (en) * 2002-09-20 2005-10-31 Alcon, Inc. Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
EP1551417B1 (en) * 2002-10-18 2008-09-10 Joel S. Echols Three layer tear formulation
US20050187192A1 (en) * 2004-02-20 2005-08-25 Kucera Pharmaceutical Company Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
PL2574341T3 (pl) 2004-03-29 2017-09-29 University Of South Florida Efektywne leczenie guzów i raka fosforanem tricyrybiny
KR100642425B1 (ko) * 2004-07-09 2006-11-03 (유) 이도건설 친수호안 구조
US7820639B2 (en) * 2004-10-01 2010-10-26 Lindstrom Richard L Ophthalmic compositions including lubricant, deturgescent agent, and glycosaminoglycan and methods of using the same
US7638142B2 (en) * 2005-10-12 2009-12-29 Vitamin Science, Inc. Therapeutic composition for the treatment of dry eye syndrome
US8669241B2 (en) * 2008-12-02 2014-03-11 Rohto Pharmaceutical Co., Ltd. Ophthalmic composition
GB0907413D0 (en) 2009-04-29 2009-06-10 Equateq Ltd Novel methods
HUE037660T2 (hu) * 2011-01-26 2018-09-28 Allergan Inc Androgén készítmény szembetegség kezelésére
IL212725A (en) * 2011-05-05 2016-06-30 Resdevco Res And Dev Co Glycerol Preparation for Non-surgical Conjunctivochalysis
RS59271B1 (sr) * 2013-02-01 2019-10-31 Allergan Inc Veštačke suze koje se sastoje od natrijum-hijaluronata i karboksimetil celuloze
CN105899485B (zh) * 2013-11-15 2018-10-19 尊严科学有限公司 多不饱和羟基脂肪酸的药学上可接受的盐

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US3991759A (en) 1975-10-28 1976-11-16 Alza Corporation Method and therapeutic system for treating aqueous deficient dry eye
US4131651A (en) 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
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US4421748A (en) 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
GB8319073D0 (en) 1983-07-14 1983-08-17 Efamol Ltd Fatty acid compositions
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US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
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US4883658A (en) 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
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JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
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EP0546728A3 (en) 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
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Also Published As

Publication number Publication date
DE60021908D1 (de) 2005-09-15
CA2388044A1 (en) 2001-05-17
US6429227B1 (en) 2002-08-06
DE60021908T2 (de) 2006-04-06
CN1387503A (zh) 2002-12-25
PL356093A1 (en) 2004-06-14
HK1045302A1 (en) 2002-11-22
AU776187B2 (en) 2004-09-02
DK1228028T3 (da) 2005-11-14
KR20020050240A (ko) 2002-06-26
ATE301630T1 (de) 2005-08-15
EP1228028B1 (en) 2005-08-10
ES2242643T3 (es) 2005-11-16
BR0015436A (pt) 2002-07-16
AU1101401A (en) 2001-06-06
TR200201250T2 (tr) 2002-09-23
MXPA02004701A (es) 2004-09-10
EP1228028A1 (en) 2002-08-07
HK1045302B (zh) 2005-10-14
JP2003513949A (ja) 2003-04-15
TWI283176B (en) 2007-07-01
WO2001034549A1 (en) 2001-05-17
PT1228028E (pt) 2005-10-31

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Legal Events

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FA Abandonment or withdrawal