AR004686A1 - Derivado de carboestirilo, composicion farmaceutica que lo contiene y procedimiento para la preparacion de dicho derivado - Google Patents
Derivado de carboestirilo, composicion farmaceutica que lo contiene y procedimiento para la preparacion de dicho derivadoInfo
- Publication number
- AR004686A1 AR004686A1 ARP960104540A ARP960104540A AR004686A1 AR 004686 A1 AR004686 A1 AR 004686A1 AR P960104540 A ARP960104540 A AR P960104540A AR P960104540 A ARP960104540 A AR P960104540A AR 004686 A1 AR004686 A1 AR 004686A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivative
- activity
- optionally substituted
- alkyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un derivado de carboestirilo de la formula (I): en donde A es un alquileno inferior, R es H, halogeno o alcoxilo inferior; R1 y R2 son cada uno alquiloinferior que son opcionalmente sustituidos por OH, alcoxilo inferior, alcoxilo inferior fenilo oalcanoiloxilo inferior, cicloalquilo que es sustituidoopcionalmente por OH, alcoxilo inferior - hidroxilo o alcanoiloxilo inferior, o amino que es opcionalmente sustituido por alquilo inferior o cicloalquilo; R3es H, alquilo inferior, alqueniloinfer ior o alquilo inferior hidroxilo, y el enlace entre posiciones 3- y 4- del nucleo de carboesterilo es simple o doble,a condicion de que cuando R y R3 sean H, R1 y R2 no deberian ser alquilo inferior insustituido o cicloalquiloinsustituido, o una sal de los mismos, loscuales presentan actividad antitrombotica, actividad inhibitoria de espesamiento de la intima actividad disociativa de la masa de plaquetas yactividad que incrementa el flujo sanguineo en elcerebro y en los va sos perifericos, y por tanto, son utiles como medicina en profilaxis otratamiento de diversas enfermedades isquemicas. Se describe un proceso para preparar el derivado de carboestirilo arriba mencionado y unacomposicion quecontiene el comp uesto activo en cantidad terapeuticamente efectiva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25870595 | 1995-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004686A1 true AR004686A1 (es) | 1999-03-10 |
Family
ID=17323960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104540A AR004686A1 (es) | 1995-10-05 | 1996-09-30 | Derivado de carboestirilo, composicion farmaceutica que lo contiene y procedimiento para la preparacion de dicho derivado |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6143763A (es) |
| EP (1) | EP0796248B1 (es) |
| KR (1) | KR100230639B1 (es) |
| CN (1) | CN1131213C (es) |
| AR (1) | AR004686A1 (es) |
| AT (1) | ATE204255T1 (es) |
| AU (1) | AU690861B2 (es) |
| CA (1) | CA2207185C (es) |
| DE (1) | DE69614503T2 (es) |
| ES (1) | ES2162655T3 (es) |
| HK (1) | HK1002194A1 (es) |
| MX (1) | MX9704145A (es) |
| TW (1) | TW338037B (es) |
| WO (1) | WO1997012869A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL136605A0 (en) | 1998-03-31 | 2001-06-14 | Warner Lambert Co | Quinolones as serine protease inhibitors |
| AU2005210326B2 (en) * | 2004-02-09 | 2009-10-22 | Nissan Chemical Industries, Ltd. | Drug for inhibiting vascular intimal hyperplasia |
| JP4892477B2 (ja) * | 2005-06-08 | 2012-03-07 | 興和株式会社 | 新規なトリグリセリド低下剤 |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| RU2553676C2 (ru) | 2009-08-21 | 2015-06-20 | Оцука Фармасьютикал Ко., Лтд. | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНОГО БЕНЗО[b][1,4]ДИАЗЕПИН-2,4-ДИОНА |
| EP2801361A4 (en) | 2012-01-05 | 2015-11-18 | Kowa Co | CONVEYOR FOR THE DEVELOPMENT OF COLLATERAL BLOOD CIRCULATION |
| US11166948B2 (en) | 2017-09-13 | 2021-11-09 | National University Corporation Hamamatsu University School Of Medicine | Pharmaceutical composition for treatment of aortic aneurysm |
| US20220184058A1 (en) | 2019-03-13 | 2022-06-16 | National University Corporation Hamamatsu University School Of Medicine | Pharmaceutical composition for treating aortic aneurysm |
| GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2093633A1 (en) * | 1991-08-23 | 1993-02-24 | Seiji Sato | Carbostyril derivative and platelets aggregation inhibitory agent |
-
1996
- 1996-09-25 TW TW085111708A patent/TW338037B/zh not_active IP Right Cessation
- 1996-09-30 AR ARP960104540A patent/AR004686A1/es active IP Right Grant
- 1996-10-04 CN CN96191700A patent/CN1131213C/zh not_active Expired - Fee Related
- 1996-10-04 EP EP96932816A patent/EP0796248B1/en not_active Expired - Lifetime
- 1996-10-04 DE DE69614503T patent/DE69614503T2/de not_active Expired - Lifetime
- 1996-10-04 AT AT96932816T patent/ATE204255T1/de active
- 1996-10-04 US US08/849,664 patent/US6143763A/en not_active Expired - Lifetime
- 1996-10-04 AU AU71457/96A patent/AU690861B2/en not_active Ceased
- 1996-10-04 KR KR1019970703738A patent/KR100230639B1/ko not_active IP Right Cessation
- 1996-10-04 WO PCT/JP1996/002892 patent/WO1997012869A1/en active IP Right Grant
- 1996-10-04 CA CA002207185A patent/CA2207185C/en not_active Expired - Fee Related
- 1996-10-04 ES ES96932816T patent/ES2162655T3/es not_active Expired - Lifetime
- 1996-10-04 MX MX9704145A patent/MX9704145A/es unknown
-
1998
- 1998-02-13 HK HK98101142A patent/HK1002194A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MX9704145A (es) | 1997-09-30 |
| CA2207185A1 (en) | 1997-04-10 |
| DE69614503T2 (de) | 2002-04-11 |
| EP0796248A1 (en) | 1997-09-24 |
| CN1131213C (zh) | 2003-12-17 |
| HK1002194A1 (en) | 1998-08-07 |
| AU7145796A (en) | 1997-04-28 |
| CA2207185C (en) | 2008-08-19 |
| ATE204255T1 (de) | 2001-09-15 |
| DE69614503D1 (en) | 2001-09-20 |
| EP0796248B1 (en) | 2001-08-16 |
| CN1172478A (zh) | 1998-02-04 |
| ES2162655T3 (es) | 2002-01-01 |
| KR100230639B1 (ko) | 1999-11-15 |
| AU690861B2 (en) | 1998-04-30 |
| TW338037B (en) | 1998-08-11 |
| WO1997012869A1 (en) | 1997-04-10 |
| US6143763A (en) | 2000-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |