MX9704145A - Derivados de carboestirilo. - Google Patents
Derivados de carboestirilo.Info
- Publication number
- MX9704145A MX9704145A MX9704145A MX9704145A MX9704145A MX 9704145 A MX9704145 A MX 9704145A MX 9704145 A MX9704145 A MX 9704145A MX 9704145 A MX9704145 A MX 9704145A MX 9704145 A MX9704145 A MX 9704145A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- optionally substituted
- cycloalkyl
- lower alkoxy
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un derivado de carboestirilo de la formula (1) en donde A es alquileno inferior, R es H, halogeno o alcoxi inferior; R1 y R2 son cada uno alquilo inferior, que está sustituido opcionalmente por OH, alcoxi inferior, fenil-alcoxi inferior o alcanoiloxi inferior; estando sustituido opcionalmente el cicloalquilo con OH, hidroxi-alcoxi inferior o alcanoiloxi inferior; o estando sustituido opcionalmente el amino con alquilo inferior o cicloalquilo; R3 es H, alquilo inferior, alquenilo inferior o hidroxi-alquilo inferior; y las ligaduras entre las posiciones 3 y 4 del nucleo de carboestirilo es sencilla o doble; a condicion de que cuando R y R3 son H, R1 y R2 no deben ser alquilo inferior no sustituido ni cicloalquilo no sustituido; o una sal del mismo, que muestra actividades antitromboticas, actividad inhibidora del engrosamiento de la region íntima, actividad disociadora de la masa de plaquetas y actividad incrementadora del flujo sanguíneo en el cerebro y en los vasos periféricos y por lo tanto, es util como medicina en la profilaxia o en el tratamiento de diversas enfermedades isquémicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25870595 | 1995-10-05 | ||
PCT/JP1996/002892 WO1997012869A1 (en) | 1995-10-05 | 1996-10-04 | Carbostyril derivatives as antithrombotic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9704145A true MX9704145A (es) | 1997-09-30 |
Family
ID=17323960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9704145A MX9704145A (es) | 1995-10-05 | 1996-10-04 | Derivados de carboestirilo. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6143763A (es) |
EP (1) | EP0796248B1 (es) |
KR (1) | KR100230639B1 (es) |
CN (1) | CN1131213C (es) |
AR (1) | AR004686A1 (es) |
AT (1) | ATE204255T1 (es) |
AU (1) | AU690861B2 (es) |
CA (1) | CA2207185C (es) |
DE (1) | DE69614503T2 (es) |
ES (1) | ES2162655T3 (es) |
HK (1) | HK1002194A1 (es) |
MX (1) | MX9704145A (es) |
TW (1) | TW338037B (es) |
WO (1) | WO1997012869A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL136605A0 (en) | 1998-03-31 | 2001-06-14 | Warner Lambert Co | Quinolones as serine protease inhibitors |
AU2005210326B2 (en) * | 2004-02-09 | 2009-10-22 | Nissan Chemical Industries, Ltd. | Drug for inhibiting vascular intimal hyperplasia |
JP4892477B2 (ja) * | 2005-06-08 | 2012-03-07 | 興和株式会社 | 新規なトリグリセリド低下剤 |
TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
RU2553676C2 (ru) | 2009-08-21 | 2015-06-20 | Оцука Фармасьютикал Ко., Лтд. | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНОГО БЕНЗО[b][1,4]ДИАЗЕПИН-2,4-ДИОНА |
EP2801361A4 (en) | 2012-01-05 | 2015-11-18 | Kowa Co | CONVEYOR FOR THE DEVELOPMENT OF COLLATERAL BLOOD CIRCULATION |
US11166948B2 (en) | 2017-09-13 | 2021-11-09 | National University Corporation Hamamatsu University School Of Medicine | Pharmaceutical composition for treatment of aortic aneurysm |
US20220184058A1 (en) | 2019-03-13 | 2022-06-16 | National University Corporation Hamamatsu University School Of Medicine | Pharmaceutical composition for treating aortic aneurysm |
GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2093633A1 (en) * | 1991-08-23 | 1993-02-24 | Seiji Sato | Carbostyril derivative and platelets aggregation inhibitory agent |
-
1996
- 1996-09-25 TW TW085111708A patent/TW338037B/zh not_active IP Right Cessation
- 1996-09-30 AR ARP960104540A patent/AR004686A1/es active IP Right Grant
- 1996-10-04 CN CN96191700A patent/CN1131213C/zh not_active Expired - Fee Related
- 1996-10-04 EP EP96932816A patent/EP0796248B1/en not_active Expired - Lifetime
- 1996-10-04 DE DE69614503T patent/DE69614503T2/de not_active Expired - Lifetime
- 1996-10-04 AT AT96932816T patent/ATE204255T1/de active
- 1996-10-04 US US08/849,664 patent/US6143763A/en not_active Expired - Lifetime
- 1996-10-04 AU AU71457/96A patent/AU690861B2/en not_active Ceased
- 1996-10-04 KR KR1019970703738A patent/KR100230639B1/ko not_active IP Right Cessation
- 1996-10-04 WO PCT/JP1996/002892 patent/WO1997012869A1/en active IP Right Grant
- 1996-10-04 CA CA002207185A patent/CA2207185C/en not_active Expired - Fee Related
- 1996-10-04 ES ES96932816T patent/ES2162655T3/es not_active Expired - Lifetime
- 1996-10-04 MX MX9704145A patent/MX9704145A/es unknown
-
1998
- 1998-02-13 HK HK98101142A patent/HK1002194A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2207185A1 (en) | 1997-04-10 |
DE69614503T2 (de) | 2002-04-11 |
EP0796248A1 (en) | 1997-09-24 |
CN1131213C (zh) | 2003-12-17 |
HK1002194A1 (en) | 1998-08-07 |
AU7145796A (en) | 1997-04-28 |
CA2207185C (en) | 2008-08-19 |
ATE204255T1 (de) | 2001-09-15 |
DE69614503D1 (en) | 2001-09-20 |
EP0796248B1 (en) | 2001-08-16 |
CN1172478A (zh) | 1998-02-04 |
ES2162655T3 (es) | 2002-01-01 |
KR100230639B1 (ko) | 1999-11-15 |
AU690861B2 (en) | 1998-04-30 |
TW338037B (en) | 1998-08-11 |
WO1997012869A1 (en) | 1997-04-10 |
AR004686A1 (es) | 1999-03-10 |
US6143763A (en) | 2000-11-07 |
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