ES2162655T3 - Derivados de carboestirilo como agentes antitromboticos. - Google Patents
Derivados de carboestirilo como agentes antitromboticos.Info
- Publication number
- ES2162655T3 ES2162655T3 ES96932816T ES96932816T ES2162655T3 ES 2162655 T3 ES2162655 T3 ES 2162655T3 ES 96932816 T ES96932816 T ES 96932816T ES 96932816 T ES96932816 T ES 96932816T ES 2162655 T3 ES2162655 T3 ES 2162655T3
- Authority
- ES
- Spain
- Prior art keywords
- short chain
- sup
- rent
- replaced
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS DEL CARBOSTIRILO DE FORMULA (1), DONDE A ES UN ALQUILENO DE CADENA CORTA, R ES H, HALOGENO O ALCOXI, R{SUP,1} Y R{SUP,2} SON ALQUILOS DE CADENA CORTA QUE PUEDEN SUSTITUIRSE POR OH, ALCOXI DE CADENA CORTA, FENIL ALCOXI DE CADENA CORTA O ALCANOILOXI DE CADENA CORTA; CICLOALQUILO QUE PUEDE SUSTITUIRSE POR OH, HIDROXI ALCOXI DE CADENA CORTA O ALCANOILOXI DE CADENA CORTA; O AMINO QUE PUEDE SUSTITUIRSE POR ALQUILO DE CADENA CORTA O CICLOALQUILO, R{SUP,3} ES H, ALQUILO DE CADENA CORTA, ALQUENILO DE CADENA CORTA O HIDROXI ALQUILO DE CADENA CORTA. EL ENLACE ENTRE LAS POSICIONES 3 Y 4 DEL NUCLEO DEL CARBOSTIRILO PUEDE SER SENCILLO O DOBLE, SIEMPRE QUE CUANDO R Y R{SUP,3} SEAN H, R{SUP,1} Y R{SUP,2} NO SEAN SUSTITUIDOS NI POR ALQUILO DE CADENA CORTA NI POR CICLOAQUILO NI POR UNA SAL DE LOS MISMOS. ESTOS COMPUESTOS EXHIBEN ACTIVIDAD ANTITROMBOTICA, ACTIVIDAD INHIBIDORA DEL ENGROSAMIENTO DE LA INTIMA, ACTIVIDAD DE DISOCIACION PLAQUETARIA Y AUMENTO DE LA ACTIVIDAD DEL FLUJO SANGUINEO EN EL CEREBRO Y LOS VASOS PERIFERICOS, SIENDO POR TANTO UTILES COMO MEDICAMENTOS PARA LA PROFILAXIS O EL TRATAMIENTO DE DIVERSAS ENFERMEDADES ISQUEMICAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25870595 | 1995-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2162655T3 true ES2162655T3 (es) | 2002-01-01 |
Family
ID=17323960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96932816T Expired - Lifetime ES2162655T3 (es) | 1995-10-05 | 1996-10-04 | Derivados de carboestirilo como agentes antitromboticos. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6143763A (es) |
| EP (1) | EP0796248B1 (es) |
| KR (1) | KR100230639B1 (es) |
| CN (1) | CN1131213C (es) |
| AR (1) | AR004686A1 (es) |
| AT (1) | ATE204255T1 (es) |
| AU (1) | AU690861B2 (es) |
| CA (1) | CA2207185C (es) |
| DE (1) | DE69614503T2 (es) |
| ES (1) | ES2162655T3 (es) |
| HK (1) | HK1002194A1 (es) |
| MX (1) | MX9704145A (es) |
| TW (1) | TW338037B (es) |
| WO (1) | WO1997012869A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0101484A3 (en) | 1998-03-31 | 2003-02-28 | Warner Lambert Co | Quinolones as serine protease inhibitors and medicaments containing them |
| US20070161642A1 (en) * | 2004-02-09 | 2007-07-12 | Nissan Chemical Industries Ltd. | Drug for inhibiting vascular intimal hyperplasia |
| EP1894576B1 (en) * | 2005-06-08 | 2011-05-25 | Kowa Company, Ltd. | Novel triglyceride reducing agent |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| RU2553676C2 (ru) | 2009-08-21 | 2015-06-20 | Оцука Фармасьютикал Ко., Лтд. | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНОГО БЕНЗО[b][1,4]ДИАЗЕПИН-2,4-ДИОНА |
| US20140330022A1 (en) | 2012-01-05 | 2014-11-06 | Kowa Company, Ltd. | Collateral blood circulation development promoter |
| CN111093675A (zh) | 2017-09-13 | 2020-05-01 | 国立大学法人浜松医科大学 | 主动脉瘤的治疗用药物组合物 |
| KR20210144657A (ko) | 2019-03-13 | 2021-11-30 | 고쿠리츠다이가쿠호진 하마마츠이카다이가쿠 | 대동맥류의 치료용 의약 조성물 |
| GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU653060B2 (en) * | 1991-08-23 | 1994-09-15 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative and platelet agglutination inhibitor |
-
1996
- 1996-09-25 TW TW085111708A patent/TW338037B/zh not_active IP Right Cessation
- 1996-09-30 AR ARP960104540A patent/AR004686A1/es active IP Right Grant
- 1996-10-04 WO PCT/JP1996/002892 patent/WO1997012869A1/en active IP Right Grant
- 1996-10-04 AU AU71457/96A patent/AU690861B2/en not_active Ceased
- 1996-10-04 ES ES96932816T patent/ES2162655T3/es not_active Expired - Lifetime
- 1996-10-04 CN CN96191700A patent/CN1131213C/zh not_active Expired - Fee Related
- 1996-10-04 MX MX9704145A patent/MX9704145A/es unknown
- 1996-10-04 CA CA002207185A patent/CA2207185C/en not_active Expired - Fee Related
- 1996-10-04 EP EP96932816A patent/EP0796248B1/en not_active Expired - Lifetime
- 1996-10-04 US US08/849,664 patent/US6143763A/en not_active Expired - Lifetime
- 1996-10-04 KR KR1019970703738A patent/KR100230639B1/ko not_active IP Right Cessation
- 1996-10-04 AT AT96932816T patent/ATE204255T1/de active
- 1996-10-04 DE DE69614503T patent/DE69614503T2/de not_active Expired - Lifetime
-
1998
- 1998-02-13 HK HK98101142A patent/HK1002194A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AR004686A1 (es) | 1999-03-10 |
| DE69614503D1 (en) | 2001-09-20 |
| EP0796248B1 (en) | 2001-08-16 |
| WO1997012869A1 (en) | 1997-04-10 |
| US6143763A (en) | 2000-11-07 |
| MX9704145A (es) | 1997-09-30 |
| CN1131213C (zh) | 2003-12-17 |
| AU7145796A (en) | 1997-04-28 |
| CA2207185A1 (en) | 1997-04-10 |
| HK1002194A1 (en) | 1998-08-07 |
| CN1172478A (zh) | 1998-02-04 |
| TW338037B (en) | 1998-08-11 |
| EP0796248A1 (en) | 1997-09-24 |
| DE69614503T2 (de) | 2002-04-11 |
| ATE204255T1 (de) | 2001-09-15 |
| CA2207185C (en) | 2008-08-19 |
| AU690861B2 (en) | 1998-04-30 |
| KR100230639B1 (ko) | 1999-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2186677T3 (es) | Derivados de deuteroporfirina sustituidos en las posiciones 3 y 8, agentes farmaceuticos que contienen estos derivados y procedimientos para su preparacion. | |
| Agostinis et al. | Regulatory pathways in photodynamic therapy induced apoptosis | |
| Kessel | Death pathways associated with photodynamic therapy | |
| ES2162655T3 (es) | Derivados de carboestirilo como agentes antitromboticos. | |
| PT923570E (pt) | Amidas de acidos piridil-alcenoicos e piridil-alcinicos como agentes citostaticos e imunossupressivos | |
| ES2097659T3 (es) | Derivados antimitoticos de los alcaloides binarios del catharanthus roseus. | |
| ES2170141T3 (es) | 4-aminoderivados del acido micofenolico con actividad inmunosupresora. | |
| ES2126122T3 (es) | Nitrato-aminoacido-disulfuros para la terapia de enfermedades del sistema cardio-circulatorio. | |
| ES2060183T3 (es) | Un casco de soldador. | |
| ATE251140T1 (de) | N-(2 oxoacetyl oder sulphonyl)- pyrrolidine/piperidine-2-carbonsäurederivate mit verbesserter multi-drug resistenz aktivität | |
| MX9703621A (es) | Nuevos derivados aminoacidos con actividad mejorada para la resistencia a drogas multiples. | |
| DK0934309T3 (da) | Nye pyridylalkansyreamider som cytostatiske og immunosuppressive midler | |
| DK0393493T3 (da) | Fluorerede galdesyrederivater, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
| EP0858996A4 (en) | AGENT FOR PROTECTING NERVOUS CELLS | |
| ES2053907T3 (es) | Pomada topica. | |
| ATE251139T1 (de) | (+)-norcisapride verwendbar bei 5-ht3 und 5-ht4 bedingten krankheiten | |
| Kessel et al. | Delayed oxidative photodamage induced by photodynamic therapy | |
| Stockert et al. | Photodynamic damage to HeLa cell microtubules induced by thiazine dyes | |
| Xue et al. | Elevation of GRP‐78 and loss of HSP‐70 following photodynamic treatment of V79 cells: sensitization by nigericin | |
| ES2158938T3 (es) | Derivados de aminoquinazolina que tienen actividad alfa-antagonistas. | |
| ATE240745T1 (de) | Verwendung von texaphyrin bei der herstellung eines medikamentes für die augentherapie und diagnose | |
| ATE167804T1 (de) | Verwendung von nickel und bromide ionen für die behandlung von psoriasis | |
| Rosenberg et al. | Validation criteria for panic disorder as a nosological entity | |
| AR011422A1 (es) | Compuestos derivados de indolil piperidinil tiadiazolo quinolein dioxido, un procedimiento para prepararlos y formulaciones farmaceuticasque los comprenden | |
| ES2144857T3 (es) | Utilizacion de derivados benzonaftalenicos para la fabricacion de medicamentos destinados para el tratamiento de las enfermedades del sistema nervioso. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 796248 Country of ref document: ES |