TW338037B - Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition - Google Patents

Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition

Info

Publication number
TW338037B
TW338037B TW085111708A TW85111708A TW338037B TW 338037 B TW338037 B TW 338037B TW 085111708 A TW085111708 A TW 085111708A TW 85111708 A TW85111708 A TW 85111708A TW 338037 B TW338037 B TW 338037B
Authority
TW
Taiwan
Prior art keywords
inhibitory activity
activity
thinkening
phosphoriesterase
intima
Prior art date
Application number
TW085111708A
Other languages
English (en)
Inventor
Yasuo Koga
Yoshihito Kinohara
Minoru Okada
Takao Nishi
Yoshihiro Inoue
Kimura Yukio
Hiroyoshi Hidaka
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of TW338037B publication Critical patent/TW338037B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW085111708A 1995-10-05 1996-09-25 Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition TW338037B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25870595 1995-10-05

Publications (1)

Publication Number Publication Date
TW338037B true TW338037B (en) 1998-08-11

Family

ID=17323960

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085111708A TW338037B (en) 1995-10-05 1996-09-25 Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition

Country Status (14)

Country Link
US (1) US6143763A (zh)
EP (1) EP0796248B1 (zh)
KR (1) KR100230639B1 (zh)
CN (1) CN1131213C (zh)
AR (1) AR004686A1 (zh)
AT (1) ATE204255T1 (zh)
AU (1) AU690861B2 (zh)
CA (1) CA2207185C (zh)
DE (1) DE69614503T2 (zh)
ES (1) ES2162655T3 (zh)
HK (1) HK1002194A1 (zh)
MX (1) MX9704145A (zh)
TW (1) TW338037B (zh)
WO (1) WO1997012869A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1091955A1 (en) 1998-03-31 2001-04-18 Warner-Lambert Company Llc Quinolones as serine protease inhibitors
CA2553915C (en) * 2004-02-09 2010-06-01 Nissan Chemical Industries, Ltd. 3(2h)-pyridazinone compounds as vascular intimal hyperplasia inhibitor
KR101258422B1 (ko) * 2005-06-08 2013-04-26 교와 가부시키가이샤 신규의 트리글리세리드 저하제
JP5649577B2 (ja) 2009-08-21 2015-01-07 大塚製薬株式会社 ベンゾ[b][1,4]ジアゼピン−2,4−ジオン化合物の製造方法
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
EP2801361A4 (en) 2012-01-05 2015-11-18 Kowa Co CONVEYOR FOR THE DEVELOPMENT OF COLLATERAL BLOOD CIRCULATION
EP3682886A4 (en) 2017-09-13 2021-06-09 National University Corporation Hamamatsu University School of Medicine PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AORTIC ANEURISM
KR20210144657A (ko) 2019-03-13 2021-11-30 고쿠리츠다이가쿠호진 하마마츠이카다이가쿠 대동맥류의 치료용 의약 조성물
GB202019475D0 (en) 2020-12-10 2021-01-27 Cancer Research Tech Ltd Therapeutic compounds and their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2093633A1 (en) * 1991-08-23 1993-02-24 Seiji Sato Carbostyril derivative and platelets aggregation inhibitory agent

Also Published As

Publication number Publication date
CN1172478A (zh) 1998-02-04
DE69614503D1 (en) 2001-09-20
CA2207185C (en) 2008-08-19
AR004686A1 (es) 1999-03-10
HK1002194A1 (en) 1998-08-07
CN1131213C (zh) 2003-12-17
AU7145796A (en) 1997-04-28
DE69614503T2 (de) 2002-04-11
ATE204255T1 (de) 2001-09-15
CA2207185A1 (en) 1997-04-10
AU690861B2 (en) 1998-04-30
US6143763A (en) 2000-11-07
MX9704145A (es) 1997-09-30
ES2162655T3 (es) 2002-01-01
EP0796248A1 (en) 1997-09-24
EP0796248B1 (en) 2001-08-16
WO1997012869A1 (en) 1997-04-10
KR100230639B1 (ko) 1999-11-15

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees