ATE251139T1 - (+)-norcisapride verwendbar bei 5-ht3 und 5-ht4 bedingten krankheiten - Google Patents
(+)-norcisapride verwendbar bei 5-ht3 und 5-ht4 bedingten krankheitenInfo
- Publication number
- ATE251139T1 ATE251139T1 AT98940159T AT98940159T ATE251139T1 AT E251139 T1 ATE251139 T1 AT E251139T1 AT 98940159 T AT98940159 T AT 98940159T AT 98940159 T AT98940159 T AT 98940159T AT E251139 T1 ATE251139 T1 AT E251139T1
- Authority
- AT
- Austria
- Prior art keywords
- norcisapride
- related diseases
- intestinal disorders
- treating gastro
- medicament
- Prior art date
Links
- ZDLILMQNLSEPLK-UHFFFAOYSA-N 2-chloro-5-methoxy-n-piperidin-4-ylpyrimidin-4-amine Chemical compound COC1=CN=C(Cl)N=C1NC1CCNCC1 ZDLILMQNLSEPLK-UHFFFAOYSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Preparing Plates And Mask In Photomechanical Process (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97202161 | 1997-07-11 | ||
EP98200661 | 1998-03-04 | ||
PCT/EP1998/004193 WO1999002496A1 (en) | 1997-07-11 | 1998-07-07 | (+)-norcisapride useful for 5-ht3 and 5-ht4 mediated disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE251139T1 true ATE251139T1 (de) | 2003-10-15 |
Family
ID=26146686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98940159T ATE251139T1 (de) | 1997-07-11 | 1998-07-07 | (+)-norcisapride verwendbar bei 5-ht3 und 5-ht4 bedingten krankheiten |
Country Status (31)
Country | Link |
---|---|
US (2) | US20030060485A1 (de) |
EP (1) | EP1000029B1 (de) |
JP (1) | JP3529102B2 (de) |
KR (1) | KR100358374B1 (de) |
CN (1) | CN1196681C (de) |
AT (1) | ATE251139T1 (de) |
AU (1) | AU757077B2 (de) |
BG (1) | BG64824B1 (de) |
BR (1) | BR9811676A (de) |
CA (1) | CA2292480A1 (de) |
CO (1) | CO4940432A1 (de) |
CZ (1) | CZ296212B6 (de) |
DE (1) | DE69818678T2 (de) |
DK (1) | DK1000029T3 (de) |
EA (1) | EA002362B1 (de) |
EE (1) | EE04491B1 (de) |
ES (1) | ES2209190T3 (de) |
HK (1) | HK1025092A1 (de) |
HR (1) | HRP20000004A2 (de) |
HU (1) | HUP0003078A3 (de) |
ID (1) | ID24228A (de) |
IL (1) | IL133225A (de) |
MY (1) | MY129130A (de) |
NO (1) | NO315183B1 (de) |
NZ (1) | NZ502207A (de) |
PL (1) | PL190296B1 (de) |
PT (1) | PT1000029E (de) |
SK (1) | SK284941B6 (de) |
TR (1) | TR200000020T2 (de) |
TW (1) | TW553934B (de) |
WO (1) | WO1999002496A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6147093A (en) | 1996-07-19 | 2000-11-14 | Sepracor Inc. | Methods for treating gastroesophageal reflux disease |
TR200103757T2 (tr) * | 1998-06-15 | 2002-06-21 | Sepracor Inc. | Apne, bulimi ve başka bozuklukların tedavi edilmesi için optik açıdan saf (-) norsisapridin kullanımı |
IL140118A0 (en) * | 1998-06-15 | 2002-02-10 | Sepracor Inc | Use of optically pure (+) norcisapride for treating apnea, bulimia and other disorders |
EP1468685A3 (de) * | 1998-06-15 | 2004-12-15 | Sepracor Inc. | Verwendung von optisch reines (+)-Norcisapride für die Behandlung von Apnea, Bulimia und andere Krankheiten |
EP1464333A3 (de) * | 1998-06-15 | 2004-12-15 | Sepracor Inc. | Verwendung von optisch reines (-) Norcisapride in der Behandlung von Apnea, Bulimia und andere Krankheiten |
US6362202B1 (en) * | 1999-03-02 | 2002-03-26 | Sepracor Inc. | Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists |
US6353005B1 (en) | 1999-03-02 | 2002-03-05 | Sepracor, Inc. | Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist |
AU4491200A (en) * | 1999-08-03 | 2001-02-19 | Lilly Icos Llc | Beta-carboline pharmaceutical compositions |
AU2001275326C1 (en) * | 2000-06-07 | 2006-09-21 | Aryx Therapeutics | Treatment of gastroesophageal reflux disease using piperidine derivatives |
WO2002041918A2 (en) * | 2000-11-24 | 2002-05-30 | Janssen Pharmaceutica N.V. | Use of a triple combination comprising a 5ht3 antagonist, a 5ht4 agonist and a laxative for promoting intestinal lavage |
MXPA04003002A (es) * | 2001-10-08 | 2004-07-15 | Sun Pharmaceutical Ind Ltd | Un sistema de administracion espacial de farmacos para agentes antiespasmodicos. |
JP2003342186A (ja) * | 2002-05-24 | 2003-12-03 | Taisho Pharmaceut Co Ltd | 鼻炎用内服液剤組成物 |
US8138204B2 (en) | 2004-01-07 | 2012-03-20 | Aryx Therapeutics, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
US8524736B2 (en) | 2004-01-07 | 2013-09-03 | Armetheon, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
PT1704146E (pt) | 2004-01-07 | 2010-06-30 | Aryx Therapeutics Inc | Compostos estereoisoméricos e processos para o tratamento de distúrbios gastrointestinais e do sistema nervoso central |
US20060247180A1 (en) * | 2005-04-29 | 2006-11-02 | Bergey James L | Purgative composition and uses thereof |
AU2006284601B2 (en) | 2005-08-31 | 2012-12-20 | Renexxion, Llc | Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders |
KR20100026641A (ko) * | 2008-09-01 | 2010-03-10 | 동아제약주식회사 | 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법 |
AU2018302170B2 (en) * | 2017-07-19 | 2024-02-29 | Ignyta, Inc. | Pharmaceutical compositions comprising entrectinib |
WO2020014334A1 (en) * | 2018-07-11 | 2020-01-16 | Duke University | Use of sustained-release 5-hydroxytryptophan in treating gastrointestinal disorders |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
US4820715A (en) * | 1984-06-28 | 1989-04-11 | Bristol-Myers Company | Anti-emetic quinuclidinyl benzamides |
NZ225152A (en) * | 1987-07-17 | 1990-04-26 | Janssen Pharmaceutica Nv | Heterocyclically substituted piperidinyl benzamides as pharmaceuticals |
US4975439A (en) * | 1987-09-25 | 1990-12-04 | Janssen Pharmaceutical N.V. | Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
IL89848A (en) * | 1988-04-07 | 1997-08-14 | Sepracor | Chiral ester derivatives |
TW213460B (de) * | 1991-02-15 | 1993-09-21 | Hokuriku Pharmaceutical | |
TW294595B (de) * | 1992-11-20 | 1997-01-01 | Janssen Pharmaceutica Nv | |
FR2717174B1 (fr) * | 1994-03-14 | 1996-05-31 | Sanofi Sa | Utilisation de pipéridinoéthyl esters de l'acide 4-amino-5-chloro-2-méthoxybenzoïque comme 5-HT4 agonistes. |
US5712293A (en) * | 1995-06-07 | 1998-01-27 | Sepracor, Inc. | Methods for treating gastro-esophageal reflux disease and other disorders associated with the digestive tract using optically pure (-) norcisapride |
US5739151A (en) * | 1996-07-19 | 1998-04-14 | Sepracor Inc. | Method for treating emesis and central nervous system disorders using optically pure (+) norcisapride |
US6147093A (en) * | 1996-07-19 | 2000-11-14 | Sepracor Inc. | Methods for treating gastroesophageal reflux disease |
-
1998
- 1998-07-07 DK DK98940159T patent/DK1000029T3/da active
- 1998-07-07 CN CNB988069563A patent/CN1196681C/zh not_active Expired - Fee Related
- 1998-07-07 AT AT98940159T patent/ATE251139T1/de not_active IP Right Cessation
- 1998-07-07 WO PCT/EP1998/004193 patent/WO1999002496A1/en active IP Right Grant
- 1998-07-07 CA CA002292480A patent/CA2292480A1/en not_active Abandoned
- 1998-07-07 AU AU88575/98A patent/AU757077B2/en not_active Ceased
- 1998-07-07 IL IL13322598A patent/IL133225A/xx not_active IP Right Cessation
- 1998-07-07 EA EA200000057A patent/EA002362B1/ru not_active IP Right Cessation
- 1998-07-07 DE DE69818678T patent/DE69818678T2/de not_active Expired - Fee Related
- 1998-07-07 JP JP50812899A patent/JP3529102B2/ja not_active Expired - Fee Related
- 1998-07-07 HU HU0003078A patent/HUP0003078A3/hu unknown
- 1998-07-07 TR TR2000/00020T patent/TR200000020T2/xx unknown
- 1998-07-07 PL PL98337648A patent/PL190296B1/pl unknown
- 1998-07-07 SK SK1829-99A patent/SK284941B6/sk unknown
- 1998-07-07 EP EP98940159A patent/EP1000029B1/de not_active Expired - Lifetime
- 1998-07-07 BR BR9811676-2A patent/BR9811676A/pt not_active Application Discontinuation
- 1998-07-07 CZ CZ0461799A patent/CZ296212B6/cs not_active IP Right Cessation
- 1998-07-07 EE EEP200000014A patent/EE04491B1/xx not_active IP Right Cessation
- 1998-07-07 KR KR1019997012056A patent/KR100358374B1/ko not_active IP Right Cessation
- 1998-07-07 PT PT98940159T patent/PT1000029E/pt unknown
- 1998-07-07 ID IDW20000033A patent/ID24228A/id unknown
- 1998-07-07 NZ NZ502207A patent/NZ502207A/en unknown
- 1998-07-07 ES ES98940159T patent/ES2209190T3/es not_active Expired - Lifetime
- 1998-07-08 TW TW087111013A patent/TW553934B/zh not_active IP Right Cessation
- 1998-07-08 MY MYPI98003108A patent/MY129130A/en unknown
- 1998-07-09 CO CO98038980A patent/CO4940432A1/es unknown
-
1999
- 1999-11-30 BG BG103934A patent/BG64824B1/bg unknown
-
2000
- 2000-01-05 HR HR20000004A patent/HRP20000004A2/xx not_active Application Discontinuation
- 2000-01-07 NO NO20000093A patent/NO315183B1/no unknown
- 2000-07-08 HK HK00104200A patent/HK1025092A1/xx not_active IP Right Cessation
-
2002
- 2002-09-16 US US10/244,365 patent/US20030060485A1/en not_active Abandoned
-
2004
- 2004-03-23 US US10/807,035 patent/US20040176414A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE251139T1 (de) | (+)-norcisapride verwendbar bei 5-ht3 und 5-ht4 bedingten krankheiten | |
MX9707980A (es) | Derivados de 4-aminoquinazolina, composiciones que los contienen, y uso de los mismos. | |
MY117896A (en) | Quinazoline derivatives | |
BR9713186A (pt) | Inibidores de metaloprotease 1,3-diheterocìclicos | |
IS1904B (is) | Hliðstæðar aðferðir við framleiðslu á nýjum (R)-5-karbamóýl-8-flúor-3-N,N-tvíútskiptum-amínó-3,4-díhýdró-2H-1-bensópýrönum | |
SG158731A1 (en) | Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics | |
ATE256671T1 (de) | 2-phenyl-substituierte 1-(n-phenylaminoalkyl)- piperazin-derivate | |
MY124786A (en) | Bis-arylsulfones | |
ATE231849T1 (de) | Cyclopentabenzofuran-derivate und ihre verwendung | |
NO20014241D0 (no) | C16-umettede FP-selektive prostaglandinanaloger | |
UA41353C2 (uk) | Похідні алкілбензоїлгуанідинів, спосіб їх одержання, фармацевтична композиція, що має аритмічну активність | |
HUP0103712A2 (hu) | Paroxetin sók, eljárás az előállításukra és gyógyászati alkalmazásuk | |
DK557189A (da) | 1,2,3,4-tetrahydro-1,9-acridindiaminer, deres fremstilling og anvendelse som laegemidler | |
AP9901474A0 (en) | Pharmaceutical composition for treating viral diseases. | |
DE69736180D1 (de) | Behandlung von manischen erkrankungen | |
EP0804186A4 (de) | Indolditerpen alkaloide | |
PL338348A1 (en) | Thiazolobenzenoheterocyclic compounds, their production and drugs containing them | |
PL352119A1 (en) | Derivatives of aminotetraline for treatment of cardiovascular diseases | |
MY124089A (en) | Use of cetirizine for preventing the onset of asthma | |
MX9604692A (es) | Derivados de quinoxalina para el tratamiento de tinnitus. | |
HUP0103992A2 (hu) | Pregnán-glükuronidok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
JO2127B1 (en) | How to prevent asthma | |
JO1720B1 (en) | Heterocyclic derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1000029 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |