AR011422A1 - Compuestos derivados de indolil piperidinil tiadiazolo quinolein dioxido, un procedimiento para prepararlos y formulaciones farmaceuticasque los comprenden - Google Patents

Compuestos derivados de indolil piperidinil tiadiazolo quinolein dioxido, un procedimiento para prepararlos y formulaciones farmaceuticasque los comprenden

Info

Publication number
AR011422A1
AR011422A1 ARP980100185A ARP980100185A AR011422A1 AR 011422 A1 AR011422 A1 AR 011422A1 AR P980100185 A ARP980100185 A AR P980100185A AR P980100185 A ARP980100185 A AR P980100185A AR 011422 A1 AR011422 A1 AR 011422A1
Authority
AR
Argentina
Prior art keywords
piperidinyl
dioxide
understand
procedure
pharmaceutical formulations
Prior art date
Application number
ARP980100185A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR011422A1 publication Critical patent/AR011422A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos derivados de indolil piperidinil tiadiazolo quinoleín dioxido de formula (I), donde R1 es hidrogeno, C1-4 alquil, C1-4 alcoxi o halo, y R2es hidrogeno, C1-4 alquil o C1-4 alcoxi; o una sal de los mismos. Un procedimiento paraprepararlos y formulaciones farmacéuticas que loscomprenden. Los compuestos y sus sales farmacéuticamente aceptables son indicados para ser utilizados en el tratamiento de trastornos del sistemanervioso central. Son activos en pruebas in vitro que indican modulacion serotonérgica, y en particular, actividad de union en el receptor 5-HT2A.Asimismo, inhiben considerablemente la reabsorcion de serotonina y presentan muy baja afinidad en relectores alfa y D2.
ARP980100185A 1997-01-17 1998-01-16 Compuestos derivados de indolil piperidinil tiadiazolo quinolein dioxido, un procedimiento para prepararlos y formulaciones farmaceuticasque los comprenden AR011422A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9700895.7A GB9700895D0 (en) 1997-01-17 1997-01-17 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
AR011422A1 true AR011422A1 (es) 2000-08-16

Family

ID=10806121

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980100185A AR011422A1 (es) 1997-01-17 1998-01-16 Compuestos derivados de indolil piperidinil tiadiazolo quinolein dioxido, un procedimiento para prepararlos y formulaciones farmaceuticasque los comprenden

Country Status (29)

Country Link
US (1) US20010053783A1 (es)
EP (1) EP0854146B1 (es)
JP (1) JPH10204090A (es)
KR (1) KR20000070221A (es)
AR (1) AR011422A1 (es)
AT (1) ATE190617T1 (es)
AU (1) AU5569298A (es)
CA (1) CA2227132A1 (es)
CZ (1) CZ290318B6 (es)
DE (1) DE69800092T2 (es)
DK (1) DK0854146T3 (es)
EA (1) EA001469B1 (es)
ES (1) ES2144888T3 (es)
GB (1) GB9700895D0 (es)
GR (1) GR3033316T3 (es)
HU (1) HUP0000854A3 (es)
ID (1) ID21920A (es)
IL (1) IL129647A (es)
NO (1) NO993372D0 (es)
NZ (1) NZ335493A (es)
PE (1) PE99399A1 (es)
PL (1) PL334569A1 (es)
PT (1) PT854146E (es)
SI (1) SI0854146T1 (es)
SV (1) SV1998000088A (es)
TR (1) TR199901583T2 (es)
TW (1) TW396156B (es)
WO (1) WO1998031686A1 (es)
ZA (1) ZA98300B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0897921A1 (en) * 1997-08-22 1999-02-24 Eli Lilly And Company Limited Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands
GB9825413D0 (en) 1998-11-19 1999-01-13 Lilly Co Eli Pharmaceutical compounds
GB9903784D0 (en) * 1999-02-18 1999-04-14 Lilly Co Eli Pharmaceutical compounds
AR028945A1 (es) * 2000-06-19 2003-05-28 Lundbeck & Co As H Derivados de indol
KR101165996B1 (ko) 2010-04-23 2012-07-18 주식회사 녹십자 프탈라지논 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
CN105949190B (zh) * 2016-07-04 2018-06-29 烟台凯博医药科技有限公司 一种制备1，8-萘啶及衍生物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2662696A2 (fr) * 1989-12-13 1991-12-06 Rhone Poulenc Sante Antagonistes de la serotonine, leur preparation et medicaments les contenant.
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
FR2675801A1 (fr) * 1991-04-24 1992-10-30 Rhone Poulenc Rorer Sa Piperidines, leur preparation et les medicaments les contenant.
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
WO1998031686A1 (en) 1998-07-23
IL129647A0 (en) 2000-02-29
SI0854146T1 (en) 2000-10-31
PL334569A1 (en) 2000-03-13
NO993372L (no) 1999-07-08
EP0854146B1 (en) 2000-03-15
DE69800092D1 (de) 2000-04-20
GB9700895D0 (en) 1997-03-05
IL129647A (en) 2002-02-10
CZ151099A3 (cs) 1999-09-15
HUP0000854A3 (en) 2002-06-28
US20010053783A1 (en) 2001-12-20
DE69800092T2 (de) 2000-09-14
CA2227132A1 (en) 1998-07-17
ATE190617T1 (de) 2000-04-15
NO993372D0 (no) 1999-07-08
EP0854146A1 (en) 1998-07-22
CZ290318B6 (cs) 2002-07-17
GR3033316T3 (en) 2000-09-29
EA199900667A1 (ru) 2000-02-28
AU5569298A (en) 1998-08-07
PT854146E (pt) 2000-08-31
ID21920A (id) 1999-08-12
ZA98300B (en) 1998-09-10
TR199901583T2 (xx) 1999-11-22
JPH10204090A (ja) 1998-08-04
KR20000070221A (ko) 2000-11-25
EA001469B1 (ru) 2001-04-23
NZ335493A (en) 2000-09-29
PE99399A1 (es) 1999-11-11
HUP0000854A2 (hu) 2000-11-28
SV1998000088A (es) 2000-10-10
ES2144888T3 (es) 2000-06-16
DK0854146T3 (da) 2000-06-05
TW396156B (en) 2000-07-01

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