ES2162656T3 - Derivados de quinazolina. - Google Patents

Derivados de quinazolina.

Info

Publication number
ES2162656T3
ES2162656T3 ES96941787T ES96941787T ES2162656T3 ES 2162656 T3 ES2162656 T3 ES 2162656T3 ES 96941787 T ES96941787 T ES 96941787T ES 96941787 T ES96941787 T ES 96941787T ES 2162656 T3 ES2162656 T3 ES 2162656T3
Authority
ES
Spain
Prior art keywords
rent
trifluorometilo
alcoxi
ciano
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96941787T
Other languages
English (en)
Inventor
Jean-Jacques Marcel Lohmann
Laurent F A Hennequin
Andrew Peter Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26140602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2162656(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2162656T3 publication Critical patent/ES2162656T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE QUINAZOLINA DE FORMULA (I), [EN LA QUE: Y 1 REPRESENTA - O -, - S -, - CH S UB,2 , - SO -, - SO 2 -, - NR 5 CO -, - CONR 6 -, SO 2 NR 7 -, - NR 8 SO 2 - O - NR 9 (DONDE R 5 , R 6 , R 7 , R 8 Y R 9 , CADA UNO INDEPENDIENTEMENTE, REPRESENTA HIDROGENO, ALQUILO O ALCOXIALQUILO); R 1 REPRESENTA HIDROGENO, HIDROXILO, HALOGENO, NITRO, TRIFLUOROMETILO, CIANO, ALQUILO, ALCOXI, ALQUILTIO, AMINO O ALQUILAMINO. R 2 REPRESENTA HIDROGENO, HIDROXILO, HA LOGENO, ALQUILO, ALCOXI, TRIFLUOROMETILO, CIANO, AMINO O NITRO; M ES UN ENTERO COMPRENDIDO ENTRE 1 Y 5; R 3 REPRESENTA HIDROXILO, HALOGENO, ALQUILO, ALCOXI, ALCANOILOXI, TRIFLUOROMETILO, CIANO, AMINO O NITRO; R 4 REPRESENTA UN GRUPO QUE ES O CONTIENE UNA PIRIDONA, FENILO O GRUPO AROMATICO HETEROCICLICO OPCIONALMENTE SUSTITUIDOS. SE INCLUYEN ASIMISMO PROCEDIMIENTOS DE PREPARACION DE LOS MISMOS Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN UN COMPUESTO DE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO COMO INGREDIENTE ACTIVO. LOS COMPUESTOS DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES INHIBEN LOS EFECTOS DE VEGF, UNA PROPIEDAD DE MUCHO VALOR PARA EL TRATAMIENTO DE DIFERENTES ESTADOS DE ENFERMEDAD, INCLUYENDO EL CANCER Y LA ARTRITIS REUMATOIDE.
ES96941787T 1995-12-18 1996-12-13 Derivados de quinazolina. Expired - Lifetime ES2162656T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95402846 1995-12-18
EP96402190 1996-10-15

Publications (1)

Publication Number Publication Date
ES2162656T3 true ES2162656T3 (es) 2002-01-01

Family

ID=26140602

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96941787T Expired - Lifetime ES2162656T3 (es) 1995-12-18 1996-12-13 Derivados de quinazolina.

Country Status (29)

Country Link
US (4) US5962458A (es)
EP (1) EP0873319B1 (es)
JP (1) JP4291413B2 (es)
KR (1) KR100530311B1 (es)
CN (1) CN1133625C (es)
AT (1) ATE203524T1 (es)
AU (1) AU712370B2 (es)
BR (1) BR9612043A (es)
CA (1) CA2237005C (es)
CZ (1) CZ291100B6 (es)
DE (1) DE69614147T2 (es)
DK (1) DK0873319T3 (es)
ES (1) ES2162656T3 (es)
GB (1) GB9624482D0 (es)
GR (1) GR3036954T3 (es)
HU (1) HUP9901243A3 (es)
IL (1) IL124925A0 (es)
MX (1) MX9804247A (es)
MY (1) MY132405A (es)
NO (1) NO311358B1 (es)
NZ (1) NZ324007A (es)
PL (1) PL192309B1 (es)
PT (1) PT873319E (es)
RU (1) RU2194701C2 (es)
SI (1) SI0873319T1 (es)
SK (1) SK282443B6 (es)
TR (1) TR199801115T2 (es)
TW (1) TW411274B (es)
WO (1) WO1997022596A1 (es)

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RU2194701C2 (ru) 2002-12-20
DK0873319T3 (da) 2001-10-22
US20020032208A1 (en) 2002-03-14
DE69614147T2 (de) 2002-03-21
TR199801115T2 (xx) 1998-08-21
AU1106197A (en) 1997-07-14
HUP9901243A3 (en) 2001-11-28
KR20000064455A (ko) 2000-11-06
NO982784D0 (no) 1998-06-17
US6258951B1 (en) 2001-07-10
EP0873319A1 (en) 1998-10-28
IL124925A0 (en) 1999-01-26
CN1205694A (zh) 1999-01-20
CN1133625C (zh) 2004-01-07
WO1997022596A1 (en) 1997-06-26
NZ324007A (en) 1999-11-29
SI0873319T1 (en) 2002-02-28
KR100530311B1 (ko) 2006-03-09
US6362336B1 (en) 2002-03-26
GR3036954T3 (en) 2002-01-31
DE69614147D1 (de) 2001-08-30
PL192309B1 (pl) 2006-09-29
BR9612043A (pt) 1999-12-28
US6071921A (en) 2000-06-06
GB9624482D0 (en) 1997-01-15
NO311358B1 (no) 2001-11-19
HUP9901243A2 (hu) 1999-08-30
JP4291413B2 (ja) 2009-07-08
CA2237005A1 (en) 1997-06-26
PL327310A1 (en) 1998-12-07
AU712370B2 (en) 1999-11-04
ATE203524T1 (de) 2001-08-15
US5962458A (en) 1999-10-05
TW411274B (en) 2000-11-11
SK282443B6 (sk) 2002-02-05
CZ188298A3 (cs) 1998-09-16
CA2237005C (en) 2006-03-14
PT873319E (pt) 2002-01-30
JP2000515114A (ja) 2000-11-14
MY132405A (en) 2007-10-31
CZ291100B6 (cs) 2002-12-11
EP0873319B1 (en) 2001-07-25
SK82898A3 (en) 1998-11-04
MX9804247A (es) 1998-09-30

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