ES2109796T3 - Derivados de pirrolopirimidilo con efecto antiproliferante. - Google Patents

Derivados de pirrolopirimidilo con efecto antiproliferante.

Info

Publication number
ES2109796T3
ES2109796T3 ES95810271T ES95810271T ES2109796T3 ES 2109796 T3 ES2109796 T3 ES 2109796T3 ES 95810271 T ES95810271 T ES 95810271T ES 95810271 T ES95810271 T ES 95810271T ES 2109796 T3 ES2109796 T3 ES 2109796T3
Authority
ES
Spain
Prior art keywords
protein
alkyl
pirrolopirimidilo
antiproliferante
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95810271T
Other languages
English (en)
Inventor
Peter Dr Traxler
Pascal Dr Furet
Wolfgang K D Dr Brill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2109796T3 publication Critical patent/ES2109796T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA INVENCION SE REFIERE A LA UTILIZACION DE LOS COMPUESTOS CONOCIDOS QUE SIGUEN A CONTINUACION PARA TRATAMIENTO TERAPEUTICO DE ENFERMEDADES DE TUMORES Y OTRAS ENFERMEDADES PROLIFERATIVAS, COMO PSORIASIS, Y NUEVOS COMPUESTOS DE ESTE TIPO. SE TRATA DE COMPUESTOS DE UNA FORMULA I DEL TIPO DONDE N = 0 HASTA 5 Y R, EN EL CASO DE QUE N NO SEA IGUAL A 0 ES UNO O MULTIPLES SUSTITUYENTES ELEGIDOS A PARTIR DE HALOGENO, ALQUIL, TRIFLUORMETIL Y ALCOXI; Y R{SUB.1} Y R{SUB.2} DE FORMA INDEPENDIENTE UNO DE OTRO SON RESPECTIVAMENTE ALQUIL O TRIFLUORMETIL INSUSTITUIDO O SUSTITUIDO POR HALOGENO, ALQUIL O FENOXI SUSTITUIDO POR ALCOXI, DONDE TAMBIEN UNO DE AMBOS RESTOS R{SUB.1} Y R{SUB.2} PUEDE SER HIDROGENO O CONJUNTAMENTE SIGNIFICAN UNA CADENA ALQUILENO CON 2 HASTA 5 ATOMOS DE CARBONO, QUE SON SUSTITUIDOS O INSUSTITUIDOS POR ALQUIL; O SUS SALES. LOS COMPUESTOS DE LA FORMULA I INHIBEN LA PROTEINA QUINASA, POR EJEMPLO LA PROTEINA TIROSINA QUINASA DEL RECEPTOR "FACTOR DE CRECIMIENTO EPIDERMAL", EGF.
ES95810271T 1994-05-03 1995-04-25 Derivados de pirrolopirimidilo con efecto antiproliferante. Expired - Lifetime ES2109796T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH138594 1994-05-03
CH24595 1995-01-30

Publications (1)

Publication Number Publication Date
ES2109796T3 true ES2109796T3 (es) 1998-01-16

Family

ID=25684008

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95810271T Expired - Lifetime ES2109796T3 (es) 1994-05-03 1995-04-25 Derivados de pirrolopirimidilo con efecto antiproliferante.

Country Status (21)

Country Link
US (2) US5686457A (es)
EP (1) EP0682027B1 (es)
JP (1) JP3042760B2 (es)
KR (1) KR950031113A (es)
CN (1) CN1128263A (es)
AT (1) ATE159257T1 (es)
AU (1) AU695244B2 (es)
CA (1) CA2148324A1 (es)
CZ (1) CZ113195A3 (es)
DE (1) DE59500788D1 (es)
DK (1) DK0682027T3 (es)
ES (1) ES2109796T3 (es)
FI (1) FI952033A (es)
GR (1) GR3025158T3 (es)
HK (1) HK1002935A1 (es)
HU (1) HUT71818A (es)
IL (1) IL113531A0 (es)
NO (1) NO951684L (es)
NZ (1) NZ272031A (es)
PL (1) PL308426A1 (es)
SK (1) SK56195A3 (es)

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