BR112014007569A2 - marcadores de metilação diagnósticos fenótipo epitelial ou mesenquimal e a resposta ao inibidor da quinase de egfr em tumores ou células tumorais - Google Patents
marcadores de metilação diagnósticos fenótipo epitelial ou mesenquimal e a resposta ao inibidor da quinase de egfr em tumores ou células tumoraisInfo
- Publication number
- BR112014007569A2 BR112014007569A2 BR112014007569A BR112014007569A BR112014007569A2 BR 112014007569 A2 BR112014007569 A2 BR 112014007569A2 BR 112014007569 A BR112014007569 A BR 112014007569A BR 112014007569 A BR112014007569 A BR 112014007569A BR 112014007569 A2 BR112014007569 A2 BR 112014007569A2
- Authority
- BR
- Brazil
- Prior art keywords
- tumors
- response
- tumor cells
- kinase inhibitor
- egfr kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542141P | 2011-09-30 | 2011-09-30 | |
| PCT/US2012/057777 WO2013055530A1 (en) | 2011-09-30 | 2012-09-28 | Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014007569A2 true BR112014007569A2 (pt) | 2017-04-18 |
Family
ID=47071458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014007569A BR112014007569A2 (pt) | 2011-09-30 | 2012-09-28 | marcadores de metilação diagnósticos fenótipo epitelial ou mesenquimal e a resposta ao inibidor da quinase de egfr em tumores ou células tumorais |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20130084287A1 (pt) |
| EP (1) | EP2761025A1 (pt) |
| JP (1) | JP2014531213A (pt) |
| KR (1) | KR20140066783A (pt) |
| CN (1) | CN104066851A (pt) |
| AU (1) | AU2012321248A1 (pt) |
| BR (1) | BR112014007569A2 (pt) |
| CA (1) | CA2849120A1 (pt) |
| IL (1) | IL231590A0 (pt) |
| MX (1) | MX2014003698A (pt) |
| RU (1) | RU2014110228A (pt) |
| SG (1) | SG11201400996SA (pt) |
| WO (1) | WO2013055530A1 (pt) |
| ZA (1) | ZA201401968B (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013082123A2 (en) * | 2011-11-28 | 2013-06-06 | University Of Chicago | Method, system, software and medium for advanced image-based arrays for analysis and display of biomedical information |
| US20160102363A1 (en) * | 2013-05-31 | 2016-04-14 | Onconova Therapeutics, Inc. | Methods and compositions for predicting therapeutic efficacy of kinase inhibitors in patients with myelodysplastic syndrome or related disorders |
| EP3011334A1 (en) * | 2013-06-20 | 2016-04-27 | The Trustees Of The University Of Pennsylvania | Methods for diagnosing pancreatic cancer |
| WO2015066634A2 (en) * | 2013-11-04 | 2015-05-07 | Dow Agrosciences Llc | Optimal soybean loci |
| KR20160014563A (ko) * | 2014-07-29 | 2016-02-11 | 재단법인 아산사회복지재단 | Egfr-표적제제에 대한 감수성 예측용 신규한 바이오 마커 및 이의 용도 |
| US20170356051A1 (en) * | 2014-10-17 | 2017-12-14 | Tohoku University | Method for estimating sensitivity to drug therapy for colorectal cancer |
| WO2016094839A2 (en) * | 2014-12-12 | 2016-06-16 | Exact Sciences Corporation | Compositions and methods for performing methylation detection assays |
| CN113981057A (zh) | 2014-12-12 | 2022-01-28 | 精密科学公司 | 用于进行甲基化检测测定的组合物和方法 |
| US10683547B2 (en) * | 2015-05-29 | 2020-06-16 | Vito Nv | Epigenetic markers for respiratory allergy |
| WO2018009709A1 (en) * | 2016-07-06 | 2018-01-11 | Youhealth Biotech, Limited | Lung cancer methylation markers and uses thereof |
| JP7113842B2 (ja) * | 2017-03-29 | 2022-08-05 | クラウン バイオサイエンス，インコーポレイテッド（タイツァン） | 胃がんのセツキシマブ感受性を決定するためのシステムおよび方法 |
| CN107144695B (zh) * | 2017-04-19 | 2019-02-26 | 南昌大学 | Arl13b蛋白在癌症诊断中的应用 |
| WO2018216009A1 (en) * | 2017-05-22 | 2018-11-29 | The National Institute For Biotechnology In The Negev Ltd. Ben-Gurion University Of The Negev | Biomarkers for diagnosis of lung cancer |
| CN110055313B (zh) * | 2018-01-18 | 2024-03-08 | 纽克莱克斯有限公司 | 用于诊断肺癌的方法 |
| EP3775285B1 (en) * | 2018-06-15 | 2021-10-06 | Unilever IP Holdings B.V. | Epigenetic method to assess sun exposure |
| CN111521810A (zh) * | 2019-02-02 | 2020-08-11 | 中国科学院上海药物研究所 | 癌症患者根据脾酪氨酸激酶进行分层 |
| IL265451B (en) | 2019-03-18 | 2020-01-30 | Frumkin Dan | Methods and systems for the detection of methylation changes in DNA samples |
| CN110283910B (zh) * | 2019-06-21 | 2021-04-20 | 浙江大学 | 目标基因dna甲基化作为分子标志物在制备判别结直肠组织癌变进展试剂盒中的应用 |
| CN111304305B (zh) * | 2020-03-30 | 2023-05-30 | 陕西科技大学 | 一种用于检测egfr基因甲基化的试剂盒及方法 |
| CN111676286B (zh) * | 2020-05-29 | 2023-04-14 | 武汉爱基百客生物科技有限公司 | 肺癌血浆游离dna甲基化检测用的多重pcr引物系统、检测方法及应用 |
| CN115772565B (zh) * | 2021-09-08 | 2023-09-05 | 广州市基准医疗有限责任公司 | 用于辅助检测肺癌体细胞egfr基因突变的甲基化位点及其应用 |
| CN114525281B (zh) * | 2022-03-14 | 2024-03-12 | 右江民族医学院 | Esrp1启动子报告基因转录活性可视化及在去甲基化抗癌药物筛选中的应用 |
| CN115651984B (zh) * | 2022-10-20 | 2023-04-14 | 山东大学 | 一种生物标志物在评价肿瘤紫杉类化疗耐药性的应用 |
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-
2012
- 2012-09-28 AU AU2012321248A patent/AU2012321248A1/en not_active Abandoned
- 2012-09-28 BR BR112014007569A patent/BR112014007569A2/pt not_active IP Right Cessation
- 2012-09-28 MX MX2014003698A patent/MX2014003698A/es unknown
- 2012-09-28 US US13/630,363 patent/US20130084287A1/en not_active Abandoned
- 2012-09-28 CA CA2849120A patent/CA2849120A1/en not_active Abandoned
- 2012-09-28 SG SG11201400996SA patent/SG11201400996SA/en unknown
- 2012-09-28 EP EP12775890.2A patent/EP2761025A1/en not_active Ceased
- 2012-09-28 JP JP2014533357A patent/JP2014531213A/ja active Pending
- 2012-09-28 KR KR1020147011145A patent/KR20140066783A/ko not_active Application Discontinuation
- 2012-09-28 CN CN201280058401.1A patent/CN104066851A/zh active Pending
- 2012-09-28 RU RU2014110228/10A patent/RU2014110228A/ru not_active Application Discontinuation
- 2012-09-28 WO PCT/US2012/057777 patent/WO2013055530A1/en active Application Filing
-
2014
- 2014-03-18 ZA ZA2014/01968A patent/ZA201401968B/en unknown
- 2014-03-19 IL IL231590A patent/IL231590A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140066783A (ko) | 2014-06-02 |
| EP2761025A1 (en) | 2014-08-06 |
| JP2014531213A (ja) | 2014-11-27 |
| WO2013055530A1 (en) | 2013-04-18 |
| IL231590A0 (en) | 2014-05-28 |
| CA2849120A1 (en) | 2013-04-18 |
| MX2014003698A (es) | 2014-07-28 |
| US20130084287A1 (en) | 2013-04-04 |
| SG11201400996SA (en) | 2014-04-28 |
| CN104066851A (zh) | 2014-09-24 |
| ZA201401968B (en) | 2018-05-30 |
| RU2014110228A (ru) | 2015-11-10 |
| AU2012321248A1 (en) | 2014-04-24 |
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