PE20091158A1 - 5-anilinoimidazopiridinas y metodos de uso - Google Patents
5-anilinoimidazopiridinas y metodos de usoInfo
- Publication number
- PE20091158A1 PE20091158A1 PE2008002130A PE2008002130A PE20091158A1 PE 20091158 A1 PE20091158 A1 PE 20091158A1 PE 2008002130 A PE2008002130 A PE 2008002130A PE 2008002130 A PE2008002130 A PE 2008002130A PE 20091158 A1 PE20091158 A1 PE 20091158A1
- Authority
- PE
- Peru
- Prior art keywords
- halo
- alkyl
- fluor
- imidazo
- pyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Devices For Indicating Variable Information By Combining Individual Elements (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 5-ANILINOIMIDAZOPIRIDINAS DE FORMULA (I) DONDE Z1 ES CR1 O N; R1 Y R1' SON CADA UNO H, HALO, ALQUILO(C1-C3), CF3, ENTRE OTROS; Z2 ES CR2 O N; Z3 ES CR3 O N, SIEMPRE QUE SOLO UNO DE Z1, Z2 Y Z3 SEA N; R2 Y R3 SON CADA UNO H, HALO, CN, CF3, OCF3, ENTRE OTROS; R4 ES H, ALQUILO(C1-C6) O CARBOCICLILO(C3-C4); Y ES W-C(O)- O W', DONDE W ES X1-N(R5)- O R11'-O-, EN DONDE R5 ES H O ALQUILO(C1-C12); X1 ES R11' O -OR11'; R11' ES H, ALQUILO(C1-C12), ALQUENILO(C2-C8), ENTRE OTROS; W' ES UN COMPUESTO DE FORMULA (i), (ii), ENTRE OTROS, DONDE R7 ES HALO, CN, CF3, ENTRE OTROS; R8 ES ALQUILO(C1-C12), ARILO, ENTRE OTROS; Het ES HETEROARILO; X4 ES (a), EN DONDE R6 ES H, HALO, -OCF3, ENTRE OTROS; R6' ES H, HALO, NO2, ENTRE OTROS; p ES DE 0 A 3. SON COMPUESTOS PREFERIDOS: (2-HIDROXIETOXI)-AMIDA DEL ACIDO 5-(2-FLUOR-4-YODOFENILAMINO)-IMIDAZO[1,5-a]PIRIDIN-6-CARBOXILICO, ((R)-2,3-DIHIDROXI-PROPOXI)-AMIDA DEL ACIDO 5-(2-FLUOR-4-YODO-FENILAMINO)-IMIDAZO[1,5-a]PIRIDIN-6-CARBOXILICO, ((S)-2-HIDROXI-PROPOXI)-AMIDA DEL ACIDO 5-(2-FLUOR-4-YODO-FENILAMINO)-IMIDAZO[1,5-a]PIRIDIN-6-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE MEK QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCER AL PULMON, LEUCEMIA, ARTRITIS REUMATOIDEA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1512907P | 2007-12-19 | 2007-12-19 | |
US5401408P | 2008-05-16 | 2008-05-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091158A1 true PE20091158A1 (es) | 2009-08-28 |
Family
ID=40350172
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013000381A PE20131210A1 (es) | 2007-12-19 | 2008-12-18 | Derivados de 5-anilinoimidazopiridina como inhibidores de mek |
PE2008002130A PE20091158A1 (es) | 2007-12-19 | 2008-12-18 | 5-anilinoimidazopiridinas y metodos de uso |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013000381A PE20131210A1 (es) | 2007-12-19 | 2008-12-18 | Derivados de 5-anilinoimidazopiridina como inhibidores de mek |
Country Status (28)
Country | Link |
---|---|
US (4) | US7923456B2 (es) |
EP (2) | EP2690101B1 (es) |
JP (1) | JP5421925B2 (es) |
KR (1) | KR101195329B1 (es) |
CN (1) | CN101945870B (es) |
AR (1) | AR069803A1 (es) |
AU (1) | AU2008343065B2 (es) |
BR (1) | BRPI0819529A2 (es) |
CA (1) | CA2706571C (es) |
CL (1) | CL2008003810A1 (es) |
CY (2) | CY1114663T1 (es) |
DK (2) | DK2222675T3 (es) |
ES (2) | ES2437141T3 (es) |
HK (2) | HK1188209A1 (es) |
HR (1) | HRP20151002T1 (es) |
HU (1) | HUE025192T2 (es) |
IL (1) | IL205977A (es) |
MX (1) | MX2010006800A (es) |
MY (1) | MY158829A (es) |
NZ (1) | NZ586802A (es) |
PE (2) | PE20131210A1 (es) |
PL (2) | PL2222675T3 (es) |
PT (2) | PT2690101E (es) |
RU (1) | RU2441004C1 (es) |
SI (2) | SI2222675T1 (es) |
TW (1) | TWI441820B (es) |
WO (1) | WO2009085983A1 (es) |
ZA (1) | ZA201003625B (es) |
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