CL2008003810A1 - Compuestos derivados de 5-anilino imidazol[1,5-a]piridina o pirazina, inhibidores de la actividad mek quinasa; composiciones farmaceuticas que los contienen; y su uso para tratar trastornos hiperproliferativos y una enfermedad inflamatoria. - Google Patents
Compuestos derivados de 5-anilino imidazol[1,5-a]piridina o pirazina, inhibidores de la actividad mek quinasa; composiciones farmaceuticas que los contienen; y su uso para tratar trastornos hiperproliferativos y una enfermedad inflamatoria.Info
- Publication number
- CL2008003810A1 CL2008003810A1 CL2008003810A CL2008003810A CL2008003810A1 CL 2008003810 A1 CL2008003810 A1 CL 2008003810A1 CL 2008003810 A CL2008003810 A CL 2008003810A CL 2008003810 A CL2008003810 A CL 2008003810A CL 2008003810 A1 CL2008003810 A1 CL 2008003810A1
- Authority
- CL
- Chile
- Prior art keywords
- anilino
- pyrazine
- imidazole
- pyridine
- inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Devices For Indicating Variable Information By Combining Individual Elements (AREA)
Abstract
COMPUESTO DE FORMULA I:<br /> Y SUS SALES, DONDE R1, R2, Z1, Z2, Z3, X4 E Y SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA;<br /> COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE DICHO COMPUESTO, Y UN PORTADOR ACEPTABLE PARA USO<br /> FARMACÉUTICO; Y<br /> USO DE UNA CANTIDAD TERAPÉUTICAMENTE EFICAZ DE DICHA COMPOSICIÓN FARMACÉUTICA QUE SIRVE PARA<br /> PREPARAR UN MEDICAMENTO ÚTIL PARA INHIBIR EL CRECIMIENTO CELULAR ANORMAL O PARA TRATAR UN TRASTOMO HIPERPROLIFERATIVO Y UN TRASTORNO INFLAMATORIO.<br />
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1512907P | 2007-12-19 | 2007-12-19 | |
| US5401408P | 2008-05-16 | 2008-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008003810A1 true CL2008003810A1 (es) | 2009-05-22 |
Family
ID=40350172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008003810A CL2008003810A1 (es) | 2007-12-19 | 2008-12-18 | Compuestos derivados de 5-anilino imidazol[1,5-a]piridina o pirazina, inhibidores de la actividad mek quinasa; composiciones farmaceuticas que los contienen; y su uso para tratar trastornos hiperproliferativos y una enfermedad inflamatoria. |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US7923456B2 (es) |
| EP (2) | EP2222675B1 (es) |
| JP (1) | JP5421925B2 (es) |
| KR (1) | KR101195329B1 (es) |
| CN (1) | CN101945870B (es) |
| AR (1) | AR069803A1 (es) |
| AU (1) | AU2008343065B2 (es) |
| BR (1) | BRPI0819529A2 (es) |
| CA (1) | CA2706571C (es) |
| CL (1) | CL2008003810A1 (es) |
| CY (2) | CY1114663T1 (es) |
| DK (2) | DK2222675T3 (es) |
| ES (2) | ES2437141T3 (es) |
| HK (2) | HK1147254A1 (es) |
| HR (1) | HRP20151002T1 (es) |
| HU (1) | HUE025192T2 (es) |
| IL (1) | IL205977A (es) |
| MX (1) | MX2010006800A (es) |
| MY (1) | MY158829A (es) |
| NZ (1) | NZ586802A (es) |
| PE (2) | PE20131210A1 (es) |
| PL (2) | PL2222675T3 (es) |
| PT (2) | PT2690101E (es) |
| RU (1) | RU2441004C1 (es) |
| SI (2) | SI2690101T1 (es) |
| TW (1) | TWI441820B (es) |
| WO (1) | WO2009085983A1 (es) |
| ZA (1) | ZA201003625B (es) |
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