WO2010074607A3 - Действующее вещество и фармацевтическая композиция для лечения алкогольной зависимости, способ получения и применения - Google Patents

Действующее вещество и фармацевтическая композиция для лечения алкогольной зависимости, способ получения и применения Download PDF

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Publication number
WO2010074607A3
WO2010074607A3 PCT/RU2009/000691 RU2009000691W WO2010074607A3 WO 2010074607 A3 WO2010074607 A3 WO 2010074607A3 RU 2009000691 W RU2009000691 W RU 2009000691W WO 2010074607 A3 WO2010074607 A3 WO 2010074607A3
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optionally substituted
active substance
alkyl
denotes
hydrogen
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PCT/RU2009/000691
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French (fr)
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WO2010074607A2 (ru
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Андрей Александрович Иващенко
Александр Васильевич ИВАЩЕНКО
Николай Филиппович Савчук
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Алла Xem, Ллс
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Priority to EA201100817A priority Critical patent/EA020328B1/ru
Priority to US13/133,948 priority patent/US20110245231A1/en
Publication of WO2010074607A2 publication Critical patent/WO2010074607A2/ru
Publication of WO2010074607A3 publication Critical patent/WO2010074607A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к действующему веществу для лечения алкогольной зависимости, фармацевтической композиции, лекарственному средству и способу лечения алкогольной зависимости от употребления продуктов, содержащих этиловый спирт. Предложено действующее вещество для лечения алкогольной зависимости людей и теплокровных животных, представляющее собой замещенные 1H-бензимидазолы общей формулы 1 или их фармацевтически приемлемые соли и/или гидраты где: W представляет собой атом серы или группу S=O; R1 представляет собой один или более заместителей, выбранных из водорода, галогена, C1-C4 алкила, C1-C4 алкилокси, необязательно замещенного азагетероциклила; R2 представляет собой водород или необязательно замещенный C1-C4 алкил; R3 и R4 независимо друг от друга представляют собой необязательно одинаковые заместители, выбранные из водорода или необязательно замещенного C1-C4 алкила; R5 представляет собой алкильный заместитель, выбранный из водорода, необязательно замещенного C1-C7 алкила, необязательно замещенного арила, необязательно замещенного гетероциклила, C1-C4 алкоксикарбонила, необязательно замещенного аминокарбонила.
PCT/RU2009/000691 2008-12-15 2009-12-15 Действующее вещество и фармацевтическая композиция для лечения алкогольной зависимости, способ получения и применения WO2010074607A2 (ru)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EA201100817A EA020328B1 (ru) 2008-12-15 2009-12-15 Способ лечения алкогольной зависимости
US13/133,948 US20110245231A1 (en) 2008-12-15 2009-12-15 Active substance and pharmaceutical composition for treating alcohol dependence, and a method for obtaining and the use of said active substance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2008149076 2008-12-15
RU2008149076/04A RU2401831C2 (ru) 2008-12-15 2008-12-15 Средство, снижающее влечение к алкоголю, фармацевтическая композиция и способы ее получения, лекарственное средство и способ лечения

Publications (2)

Publication Number Publication Date
WO2010074607A2 WO2010074607A2 (ru) 2010-07-01
WO2010074607A3 true WO2010074607A3 (ru) 2010-08-19

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PCT/RU2009/000691 WO2010074607A2 (ru) 2008-12-15 2009-12-15 Действующее вещество и фармацевтическая композиция для лечения алкогольной зависимости, способ получения и применения

Country Status (4)

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US (1) US20110245231A1 (ru)
EA (1) EA020328B1 (ru)
RU (1) RU2401831C2 (ru)
WO (1) WO2010074607A2 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9504691B2 (en) * 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
BR102016024814A2 (pt) * 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1177792A2 (en) * 2000-07-27 2002-02-06 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
RU2223752C1 (ru) * 2002-04-03 2004-02-20 Закрытое акционерное общество "Фарматек" Фармацевтическая композиция, обладающая антидепрессивным действием, и способ ее получения

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1177792A2 (en) * 2000-07-27 2002-02-06 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
RU2223752C1 (ru) * 2002-04-03 2004-02-20 Закрытое акционерное общество "Фарматек" Фармацевтическая композиция, обладающая антидепрессивным действием, и способ ее получения

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"RLS-2007", ENTSIKLOPEDIYA LEKARSTV, 2006, MOSCOW, pages 696 - 697, 936-937 *
BAENA JOSE M. ET AL.: "Relation between alcohol consumption and the success of Helicobacter pylori eradication therapy using omeprazole, clarithromycin and amoxillin for 1 week", EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol. 14, no. 3, 2002, pages 291 - 296 *
CHEMICAL ABSTRACTS, vol. 136, no. 379488, Columbus, Ohio, US; *
KOZHINOVA T.A. ET AL.: "Kupirovanie alkogolnogo abstinentnogo sindroma (issledovanie effectivnosti i perenosimosti afobasola)", NARKOLOGIYA, 2007, pages 34 - 39, Retrieved from the Internet <URL:http://elibrary.ru/item.asp?id=9586845> [retrieved on 20100524] *
NOVOSTI FARMATSII.: "''Bemaktor''-novy preparat dlya obschemeditsinskoi praktiki.", TERRA MEDIKA NOVA., 1998, Retrieved from the Internet <URL:http://medi.ru/doc/8780412.htm> [retrieved on 20100524] *
OKOVITY S.V. ET AL.: "Gepatoprotektorny effekt bemitila u bolnykh s khronicheskimi alkogolnymi porazheniyami pecheni. Ezhemesyachny nauchno-praktichesky zhurnal", NARKOLOGIYA, 2002, pages 19 - 23 *

Also Published As

Publication number Publication date
EA201100817A1 (ru) 2011-10-31
US20110245231A1 (en) 2011-10-06
RU2401831C2 (ru) 2010-10-20
WO2010074607A2 (ru) 2010-07-01
RU2008149076A (ru) 2010-06-20
EA020328B1 (ru) 2014-10-30

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