MX336271B - Compuestos de triazolopiridina inhibidores de jak y los metodos. - Google Patents

Compuestos de triazolopiridina inhibidores de jak y los metodos.

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Publication number
MX336271B
MX336271B MX2010014002A MX2010014002A MX336271B MX 336271 B MX336271 B MX 336271B MX 2010014002 A MX2010014002 A MX 2010014002A MX 2010014002 A MX2010014002 A MX 2010014002A MX 336271 B MX336271 B MX 336271B
Authority
MX
Mexico
Prior art keywords
methods
inhibitor compounds
jak inhibitor
compound
formula
Prior art date
Application number
MX2010014002A
Other languages
English (en)
Other versions
MX2010014002A (es
Inventor
Richard Pastor
Michael Siu
Bing-Yan Zhu
Steven R Magnuson
He Haiying
Xiao Yisong
Zheng Jifu
Xu Xing
Zhao Junping
Wendy Liu
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41434472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX336271(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2010014002A publication Critical patent/MX2010014002A/es
Publication of MX336271B publication Critical patent/MX336271B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Diabetes (AREA)
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  • Cardiology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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Abstract

Un compuesto de la Fórmula I, enantiómeros, diastereómeros, tautómeros o las sales farmacéuticamente aceptables de ellos, donde R1, R2, R3, R4 y R5 están definidos aquí, son útiles como inhibidores de JAK quinasa. Se revelan una composición farmacéutica que incluye un compuesto de la Fórmula I y un portador, adyuvante o vehículo farmacéuticamente aceptable, y los métodos de tratamiento o de disminuir la severidad de una enfermedad o condición sensible de la actividad de JAK quinasa en un paciente. (Ver fórmula I).
MX2010014002A 2008-06-20 2009-06-19 Compuestos de triazolopiridina inhibidores de jak y los metodos. MX336271B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7451008P 2008-06-20 2008-06-20
PCT/US2009/048041 WO2009155565A1 (en) 2008-06-20 2009-06-19 Triazolopyridine jak inhibitor compounds and methods

Publications (2)

Publication Number Publication Date
MX2010014002A MX2010014002A (es) 2011-02-15
MX336271B true MX336271B (es) 2016-01-13

Family

ID=41434472

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010014002A MX336271B (es) 2008-06-20 2009-06-19 Compuestos de triazolopiridina inhibidores de jak y los metodos.

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US (4) US20100035875A1 (es)
EP (1) EP2296475A4 (es)
JP (1) JP5595389B2 (es)
KR (1) KR20110031475A (es)
CN (1) CN102131390A (es)
AU (1) AU2009259867A1 (es)
BR (1) BRPI0909945A2 (es)
CA (1) CA2726844C (es)
CL (1) CL2010001486A1 (es)
IL (1) IL209764A0 (es)
MX (1) MX336271B (es)
PE (1) PE20110063A1 (es)
RU (1) RU2561104C2 (es)
SG (1) SG178807A1 (es)
WO (1) WO2009155565A1 (es)

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GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
JP5595389B2 (ja) 2008-06-20 2014-09-24 ジェネンテック， インコーポレイテッド トリアゾロピリジンｊａｋ阻害剤化合物と方法
CA2727036C (en) * 2008-06-20 2017-03-21 Genentech, Inc. Triazolopyridine jak inhibitor compounds and methods
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
AU2011211410B2 (en) * 2009-02-13 2013-01-31 Fovea Pharmaceuticals Sa [1,2,4] triazolo [1,5-A] pyridines as kinase inhibitors
PE20120110A1 (es) * 2009-02-13 2012-02-20 Fovea Pharmaceuticals [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa
KR20120023072A (ko) 2009-05-12 2012-03-12 브리스톨-마이어스 스큅 컴퍼니 （Ｓ）-7-（〔1,2,4〕트리아졸〔1,5-ａ〕피리딘-6-일）-4-（3,4-디클로로페닐）-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
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