PH12014502721A1 - IMIDAZO[1,2-b] PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS - Google Patents

IMIDAZO[1,2-b] PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS

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Publication number
PH12014502721A1
PH12014502721A1 PH12014502721A PH12014502721A PH12014502721A1 PH 12014502721 A1 PH12014502721 A1 PH 12014502721A1 PH 12014502721 A PH12014502721 A PH 12014502721A PH 12014502721 A PH12014502721 A PH 12014502721A PH 12014502721 A1 PH12014502721 A1 PH 12014502721A1
Authority
PH
Philippines
Prior art keywords
imidazo
kinase inhibitors
pyridazine derivatives
acceptable salt
pharmacologically acceptable
Prior art date
Application number
PH12014502721A
Other versions
PH12014502721B1 (en
Inventor
Takeda Yasuyuki
Yoshikawa Kenji
Kagoshima Yoshiko
Yamamoto Yuko
Tanaka Ryoichi
Tominaga Yuichi
Kiga Masaki
Hamada Yoshito
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of PH12014502721B1 publication Critical patent/PH12014502721B1/en
Publication of PH12014502721A1 publication Critical patent/PH12014502721A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems

Abstract

The present invention provides a compound useful in treating tumors by ROS1 kinase enzyme activity inhibitory action and NTRK kinase enzyme inhibitory action, or a pharmacologically acceptable salt thereof. A compound having an imidazo[1,2-b]pyridazine structure represented by general formula (I), a pharmacologically acceptable salt thereof, or pharmaceutical compositions comprising such compounds. (In the formula, R1, G, T, Y1, Y2, Y3, and Y4 are as defined in the present description.)
PH12014502721A 2012-06-04 2014-12-04 IMIDAZO[1,2-b] PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS PH12014502721A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012127079 2012-06-04
PCT/JP2013/065328 WO2013183578A1 (en) 2012-06-04 2013-06-03 IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVE AS KINASE INHIBITOR

Publications (2)

Publication Number Publication Date
PH12014502721B1 PH12014502721B1 (en) 2015-02-02
PH12014502721A1 true PH12014502721A1 (en) 2015-02-02

Family

ID=49711970

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12014502721A PH12014502721A1 (en) 2012-06-04 2014-12-04 IMIDAZO[1,2-b] PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS

Country Status (32)

Country Link
US (2) US9187489B2 (en)
EP (1) EP2857404B1 (en)
JP (1) JP5814467B2 (en)
KR (1) KR101781255B1 (en)
CN (1) CN104520300B (en)
AU (1) AU2013272701B2 (en)
BR (1) BR112014029851B1 (en)
CA (1) CA2874819C (en)
CO (1) CO7160119A2 (en)
CY (1) CY1119607T1 (en)
DK (1) DK2857404T3 (en)
ES (1) ES2648228T3 (en)
HK (1) HK1207374A1 (en)
HR (1) HRP20171724T1 (en)
HU (1) HUE037221T2 (en)
IL (1) IL236075A (en)
IN (1) IN2014MN02497A (en)
LT (1) LT2857404T (en)
MX (1) MX357021B (en)
MY (1) MY170326A (en)
NO (1) NO2857404T3 (en)
NZ (1) NZ702574A (en)
PH (1) PH12014502721A1 (en)
PL (1) PL2857404T3 (en)
PT (1) PT2857404T (en)
RS (1) RS56625B1 (en)
RU (1) RU2635917C2 (en)
SG (1) SG11201408052WA (en)
SI (1) SI2857404T1 (en)
TW (1) TWI585088B (en)
WO (1) WO2013183578A1 (en)
ZA (1) ZA201408843B (en)

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Publication number Publication date
IL236075A (en) 2017-10-31
KR101781255B1 (en) 2017-09-22
AU2013272701B2 (en) 2017-12-21
EP2857404A1 (en) 2015-04-08
MX357021B (en) 2018-06-25
AU2013272701A2 (en) 2015-01-22
ZA201408843B (en) 2016-01-27
US20150051190A1 (en) 2015-02-19
ES2648228T3 (en) 2017-12-29
BR112014029851B1 (en) 2023-01-03
MX2014014803A (en) 2015-02-12
IN2014MN02497A (en) 2015-07-17
US20160046639A1 (en) 2016-02-18
SI2857404T1 (en) 2017-11-30
RU2635917C2 (en) 2017-11-17
RS56625B1 (en) 2018-03-30
IL236075A0 (en) 2015-02-01
SG11201408052WA (en) 2015-01-29
WO2013183578A1 (en) 2013-12-12
TW201400486A (en) 2014-01-01
EP2857404A4 (en) 2016-01-20
NZ702574A (en) 2016-07-29
US9751887B2 (en) 2017-09-05
DK2857404T3 (en) 2017-12-04
BR112014029851A2 (en) 2017-06-27
AU2013272701A1 (en) 2015-01-15
CA2874819A1 (en) 2013-12-12
PH12014502721B1 (en) 2015-02-02
MY170326A (en) 2019-07-17
EP2857404B1 (en) 2017-08-23
LT2857404T (en) 2017-11-10
CO7160119A2 (en) 2015-01-15
CA2874819C (en) 2017-06-20
HUE037221T2 (en) 2018-08-28
HRP20171724T1 (en) 2018-01-12
JPWO2013183578A1 (en) 2016-01-28
PL2857404T3 (en) 2018-04-30
PT2857404T (en) 2017-11-23
RU2014153627A (en) 2016-08-10
JP5814467B2 (en) 2015-11-17
KR20150014942A (en) 2015-02-09
US9187489B2 (en) 2015-11-17
TWI585088B (en) 2017-06-01
NO2857404T3 (en) 2018-01-20
CN104520300B (en) 2016-12-21
CN104520300A (en) 2015-04-15
CY1119607T1 (en) 2018-04-04
HK1207374A1 (en) 2016-01-29

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