BR0213172A - Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico - Google Patents

Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico

Info

Publication number
BR0213172A
BR0213172A BR0213172-2A BR0213172A BR0213172A BR 0213172 A BR0213172 A BR 0213172A BR 0213172 A BR0213172 A BR 0213172A BR 0213172 A BR0213172 A BR 0213172A
Authority
BR
Brazil
Prior art keywords
lower alkyl
pyridine
amino
carboxylic acid
acid amide
Prior art date
Application number
BR0213172-2A
Other languages
English (en)
Inventor
Matthias Heinrich Nettekoven
Sebastien Schmitt
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0213172A publication Critical patent/BR0213172A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"AMIDA DO áCIDO 8-AMINO-[1,2,4]TRIAZOLO[1,5-a] PIRIDINA-6-CARBOXìLICO". A invenção refere-se a compostos de fórmula (I), onde R^ 1^ é -NR<39>R" onde R<39>e R" são independentemente entre si, alquila inferior, -(CH~ 2~)~ n~C(O)NR^ a^R^ b^-(CH~ 2~)~ n~-heteroarila, (CH~ 2~)~ n~-arila, -(CH~ 2~)~ n~-CN, -(CH~ 2~)~ n~-O-alquila inferior ou -(CH~ 2~)~ n~-cicloalquila, ou R<39> e R" formam, juntamente com o átomo de nitrogênio, um anel não aromático de cinco ou seis membros que pode conter um heteroátomo O ou S adicional e cujos anéis podem ser não substituídos ou substituídos com um ou dois substituintes, selecionados dentre o grupo alquila inferior, -C(O)NR^ A^ R^ b^ ou -(CH~ 2~)~ n~-O-alquila inferior e R^ aR^ b^ são independentemente entre si, hidrogênio ou alquila inferior, R^ 2^ é arila ou heteroarila, substituída ou não substituída com alquila inferior ou halogênio. n é 0, 1, 2 ou 3, e a seus sais farmaceuticamente aceitáveis. Os compostos são de utilidade no tratamento de doenças associadas com o receptor A~ 2~ de adenosina.
BR0213172-2A 2001-10-08 2002-10-04 Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico BR0213172A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01123948 2001-10-08
PCT/EP2002/011152 WO2003030904A1 (en) 2001-10-08 2002-10-04 8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide

Publications (1)

Publication Number Publication Date
BR0213172A true BR0213172A (pt) 2004-09-14

Family

ID=8178876

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213172-2A BR0213172A (pt) 2001-10-08 2002-10-04 Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico

Country Status (13)

Country Link
US (1) US6689790B2 (pt)
EP (1) EP1435952A1 (pt)
JP (1) JP4101755B2 (pt)
KR (1) KR100614486B1 (pt)
CN (1) CN1564686A (pt)
AR (1) AR036734A1 (pt)
AU (1) AU2002347055B2 (pt)
BR (1) BR0213172A (pt)
CA (1) CA2462806A1 (pt)
MX (1) MXPA04003277A (pt)
PL (1) PL370067A1 (pt)
RU (1) RU2296763C2 (pt)
WO (1) WO2003030904A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5595389B2 (ja) * 2008-06-20 2014-09-24 ジェネンテック， インコーポレイテッド トリアゾロピリジンｊａｋ阻害剤化合物と方法
JP5512665B2 (ja) * 2008-06-20 2014-06-04 ジェネンテック， インコーポレイテッド トリアゾロピリジンｊａｋ阻害剤化合物と方法
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
AU2010271732B2 (en) * 2009-07-17 2016-08-25 Japan Tobacco Inc. Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer
RU2620379C2 (ru) * 2012-02-09 2017-05-25 Ф.Хоффманн-Ля Рош Аг СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 2-ФЕНИЛ[1,2,4]ТРИАЗОЛО[1,5-а]ПИРИДИНА
US9048427B2 (en) * 2013-03-06 2015-06-02 National Tsing Hua University Thin film fabrication of rubber material with piezoelectric characteristics
EP3006444B1 (en) * 2013-05-31 2017-09-27 Nissan Chemical Industries, Ltd. Heterocyclic amide compound
CN104370807B (zh) * 2014-11-13 2016-10-05 安徽星宇化工有限公司 一种6-羟基-5-硝基烟酸的合成方法及其分离提纯方法
MX2020010618A (es) 2018-04-08 2020-11-12 Beigene Ltd Derivados de pirazolotriazolopiriminina como antagonista del receptor a2a.
CN110742893B (zh) * 2018-07-23 2024-04-05 百济神州(北京)生物科技有限公司 A2a受体拮抗剂治疗癌症的方法
WO2020054712A1 (ja) * 2018-09-12 2020-03-19 日本化薬株式会社 有害生物防除剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE287263C (pt) *
AU743910B2 (en) * 1997-03-24 2002-02-07 Kyowa Hakko Kirin Co., Ltd. {1,2,4}triazolo{1,5-c}pyrimidine derivatives
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
US6506772B1 (en) * 2000-12-15 2003-01-14 Hoffmann-La Roche Inc. Substituted [1,2,4]triazolo[1,5a]pyridine derivatives with activity as adenosine receptor ligands

Also Published As

Publication number Publication date
RU2296763C2 (ru) 2007-04-10
KR20040048940A (ko) 2004-06-10
EP1435952A1 (en) 2004-07-14
AU2002347055B2 (en) 2006-10-12
KR100614486B1 (ko) 2006-08-22
MXPA04003277A (es) 2004-07-23
US20030207911A1 (en) 2003-11-06
JP4101755B2 (ja) 2008-06-18
US6689790B2 (en) 2004-02-10
RU2004114278A (ru) 2005-10-27
CA2462806A1 (en) 2003-04-17
JP2005508942A (ja) 2005-04-07
PL370067A1 (en) 2005-05-16
CN1564686A (zh) 2005-01-12
WO2003030904A1 (en) 2003-04-17
AR036734A1 (es) 2004-09-29

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE A 8.6, DA RPI 2108 DE 31/05/2011.