MXPA04003277A - Amida del acido 8-amino-?1,2,4?triazolo?1,5-a?piridina-6-carboxilico. - Google Patents

Amida del acido 8-amino-?1,2,4?triazolo?1,5-a?piridina-6-carboxilico.

Info

Publication number
MXPA04003277A
MXPA04003277A MXPA04003277A MXPA04003277A MXPA04003277A MX PA04003277 A MXPA04003277 A MX PA04003277A MX PA04003277 A MXPA04003277 A MX PA04003277A MX PA04003277 A MXPA04003277 A MX PA04003277A MX PA04003277 A MXPA04003277 A MX PA04003277A
Authority
MX
Mexico
Prior art keywords
lower alkyl
triazolo
pyridine
amino
carboxylic acid
Prior art date
Application number
MXPA04003277A
Other languages
English (en)
Inventor
Schmitt Sebastien
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA04003277A publication Critical patent/MXPA04003277A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La invencion se refiere a compuestos de formula I,(ver formula I),en la cualR1 es -NR??R???? donde R??y R???? son independientemente entre si al alquilo inferior, -(CH2)n-C(O)NR2Rb, -(CH2)n- heteroarilo , -(CH2)n-arilo, -(CH2)n-CN, -(CH2)n-O- alquilo inferior o -(CH2)n-cicloalquilo, o R??y R???? forman conjuntamente con el atomo N un anillo no aromatico de cinco o seis miembros, que puede contener un heteroatomo O o S adicional, y cuyos anillos pueden estar sustituidos o no sustituidos por uno o dos sustituyentes, seleccionados entre el grupo que comprende alquilo inferior, - C(O)NR2Rb o -(CH2)n-O-alquilo inferior y RaRb son independientemente entre si hidrogeno o alquilo inferior;R2 es arilo o heteroarilo, no sustituido o sustituido por alquilo inferior o halogeno;n es 0, 1, 2 o 3;y a sus sales farmaceuticamente aceptables. Los compuestospueden utilizarse para el tratamiento de enfermedadesrelacionadas con el receptor A2 de adenosina.
MXPA04003277A 2001-10-08 2002-10-04 Amida del acido 8-amino-?1,2,4?triazolo?1,5-a?piridina-6-carboxilico. MXPA04003277A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01123948 2001-10-08
PCT/EP2002/011152 WO2003030904A1 (en) 2001-10-08 2002-10-04 8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide

Publications (1)

Publication Number Publication Date
MXPA04003277A true MXPA04003277A (es) 2004-07-23

Family

ID=8178876

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003277A MXPA04003277A (es) 2001-10-08 2002-10-04 Amida del acido 8-amino-?1,2,4?triazolo?1,5-a?piridina-6-carboxilico.

Country Status (13)

Country Link
US (1) US6689790B2 (es)
EP (1) EP1435952A1 (es)
JP (1) JP4101755B2 (es)
KR (1) KR100614486B1 (es)
CN (1) CN1564686A (es)
AR (1) AR036734A1 (es)
AU (1) AU2002347055B2 (es)
BR (1) BR0213172A (es)
CA (1) CA2462806A1 (es)
MX (1) MXPA04003277A (es)
PL (1) PL370067A1 (es)
RU (1) RU2296763C2 (es)
WO (1) WO2003030904A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5595389B2 (ja) * 2008-06-20 2014-09-24 ジェネンテック， インコーポレイテッド トリアゾロピリジンｊａｋ阻害剤化合物と方法
JP5512665B2 (ja) * 2008-06-20 2014-06-04 ジェネンテック， インコーポレイテッド トリアゾロピリジンｊａｋ阻害剤化合物と方法
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
AU2010271732B2 (en) * 2009-07-17 2016-08-25 Japan Tobacco Inc. Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer
RU2620379C2 (ru) * 2012-02-09 2017-05-25 Ф.Хоффманн-Ля Рош Аг СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 2-ФЕНИЛ[1,2,4]ТРИАЗОЛО[1,5-а]ПИРИДИНА
US9048427B2 (en) * 2013-03-06 2015-06-02 National Tsing Hua University Thin film fabrication of rubber material with piezoelectric characteristics
EP3006444B1 (en) * 2013-05-31 2017-09-27 Nissan Chemical Industries, Ltd. Heterocyclic amide compound
CN104370807B (zh) * 2014-11-13 2016-10-05 安徽星宇化工有限公司 一种6-羟基-5-硝基烟酸的合成方法及其分离提纯方法
MX2020010618A (es) 2018-04-08 2020-11-12 Beigene Ltd Derivados de pirazolotriazolopiriminina como antagonista del receptor a2a.
CN110742893B (zh) * 2018-07-23 2024-04-05 百济神州(北京)生物科技有限公司 A2a受体拮抗剂治疗癌症的方法
WO2020054712A1 (ja) * 2018-09-12 2020-03-19 日本化薬株式会社 有害生物防除剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE287263C (es) *
AU743910B2 (en) * 1997-03-24 2002-02-07 Kyowa Hakko Kirin Co., Ltd. {1,2,4}triazolo{1,5-c}pyrimidine derivatives
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
US6506772B1 (en) * 2000-12-15 2003-01-14 Hoffmann-La Roche Inc. Substituted [1,2,4]triazolo[1,5a]pyridine derivatives with activity as adenosine receptor ligands

Also Published As

Publication number Publication date
RU2296763C2 (ru) 2007-04-10
KR20040048940A (ko) 2004-06-10
EP1435952A1 (en) 2004-07-14
AU2002347055B2 (en) 2006-10-12
KR100614486B1 (ko) 2006-08-22
US20030207911A1 (en) 2003-11-06
BR0213172A (pt) 2004-09-14
JP4101755B2 (ja) 2008-06-18
US6689790B2 (en) 2004-02-10
RU2004114278A (ru) 2005-10-27
CA2462806A1 (en) 2003-04-17
JP2005508942A (ja) 2005-04-07
PL370067A1 (en) 2005-05-16
CN1564686A (zh) 2005-01-12
WO2003030904A1 (en) 2003-04-17
AR036734A1 (es) 2004-09-29

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