WO2005047279A8 - Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain - Google Patents
Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating painInfo
- Publication number
- WO2005047279A8 WO2005047279A8 PCT/GB2004/004719 GB2004004719W WO2005047279A8 WO 2005047279 A8 WO2005047279 A8 WO 2005047279A8 GB 2004004719 W GB2004004719 W GB 2004004719W WO 2005047279 A8 WO2005047279 A8 WO 2005047279A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- 4alkyl
- haloc1
- 4alkoxy
- optionally substituted
- nitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention provides a compound of formula (I): Y-J-NH-Z wherein: Y is a quinoline or isoquinoline optionally substituted with one or two substituents independently chosen from hydroxy, halogen, haloC1-4alkyl, C1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, nitro and amino; J is pyridine, pyridazine, pyrazine, pyrimidine or triazine optionally substituted with one or two substituents independently chosen from hydroxy, halogen, haloC1-4alkyl, C1-4alkyl, C3-5cycloalkyl, C1-4alkoxy, hydroxyC1- 4alkyl, cyano, hydroxy, C1-4cycloalkoxy, C1-4alkylthio, haloC1-4alkoxy, nitro, Q, (CH2)pQ, NR2R3, -(CH2)pNR2R3 and -O(CH2)pNR2R3; wherein J is substituted at positions meta to each other by NH and Y; and Z is phenyl or pyridyl optionally substituted with one or two substituents independently selected from halogen, haloC1-4alkyl, C1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, nitro and amino; Q is phenyl, a five-membered heterocyclic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, or a six-membered heterocyclic ring containing one, two or three nitrogen atoms, optionally substituted by C1-4alkyl; each R2 and R3 is chosen from H and C1-4alkyl, or R2 and R3, together with the nitrogen atom to which they are attached, may form a six-membered ring optionally containing an oxygen atom or a further nitrogen atom, which ring is optionally substituted by C1-4alkyl or Q; p is 1, 2 or 3; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising it; its use in methods of therapy; use of it for manufacturing medicaments; and methods of using it to treat diseases requiring administration of a VR1 antagonist such as pain, cough, GERD and depression.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04798442A EP1685124A1 (en) | 2003-11-10 | 2004-11-09 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain |
| AU2004289518A AU2004289518A1 (en) | 2003-11-10 | 2004-11-09 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain |
| CA002545384A CA2545384A1 (en) | 2003-11-10 | 2004-11-09 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain |
| JP2006538935A JP2007510706A (en) | 2003-11-10 | 2004-11-09 | Substituted nitrogen-containing six-membered amino heterocycles as vanilloid-1 receptor antagonists for the treatment of pain |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0326217.7 | 2003-11-10 | ||
| GB0326217A GB0326217D0 (en) | 2003-11-10 | 2003-11-10 | Therapeutic agents |
| GB0407748.3 | 2004-04-05 | ||
| GB0407748A GB0407748D0 (en) | 2004-04-05 | 2004-04-05 | Therapeutic agents |
| US61713404P | 2004-10-08 | 2004-10-08 | |
| US60/617,134 | 2004-10-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2005047279A1 WO2005047279A1 (en) | 2005-05-26 |
| WO2005047279A8 true WO2005047279A8 (en) | 2006-08-10 |
Family
ID=34595632
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2004/004719 WO2005047279A1 (en) | 2003-11-10 | 2004-11-09 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain |
| PCT/GB2004/004730 WO2005047280A1 (en) | 2003-11-10 | 2004-11-09 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2004/004730 WO2005047280A1 (en) | 2003-11-10 | 2004-11-09 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1685124A1 (en) |
| JP (1) | JP2007510706A (en) |
| AU (1) | AU2004289518A1 (en) |
| CA (1) | CA2545384A1 (en) |
| TW (1) | TW200526196A (en) |
| WO (2) | WO2005047279A1 (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
| CA2551944A1 (en) * | 2003-12-15 | 2005-06-30 | Almirall Prodesfarma Ag | 2, 6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists |
| WO2006089311A1 (en) * | 2005-02-15 | 2006-08-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| CA2682504C (en) | 2007-04-05 | 2012-10-30 | Amgen Inc. | Aurora kinase modulators and method of use |
| EP2238105B1 (en) | 2008-01-28 | 2014-04-16 | Amorepacific Corporation | Novel compounds as vanilloid receptor antagonists |
| JP2011515401A (en) | 2008-03-20 | 2011-05-19 | アムジエン・インコーポレーテツド | Aurora kinase modulator and methods of use |
| CA2719515C (en) | 2008-04-18 | 2013-11-05 | Daewoong Pharmaceutical Co., Ltd. | A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof |
| CA2723961C (en) | 2008-05-21 | 2017-03-21 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
| JP5438103B2 (en) | 2008-07-02 | 2014-03-12 | アモーレパシフィック コーポレイション | Novel compounds as vanilloid receptor antagonists, isomers or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing the same |
| US9126935B2 (en) | 2008-08-14 | 2015-09-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| JO2885B1 (en) | 2008-12-22 | 2015-03-15 | ايلي ليلي اند كومباني | Protein kinase inhibitors |
| AR075858A1 (en) | 2009-03-18 | 2011-05-04 | Schering Corp | BICYCLE COMPOUNDS AS INHIBITORS OF DIACILGLICEROL ACILTRANSFERASA |
| WO2011017296A1 (en) * | 2009-08-04 | 2011-02-10 | Schering Corporation | 4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors |
| KR101293384B1 (en) | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | Novel pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof |
| EP2518070A1 (en) | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
| CN102558047B (en) * | 2011-12-14 | 2013-10-30 | 天津药物研究院药业有限责任公司 | Method for preparing 3-methylquinoline |
| CN102702110A (en) * | 2012-05-24 | 2012-10-03 | 盛世泰科生物医药技术(苏州)有限公司 | Preparation method of 4-amino-5, 6-dichloropyrimidine |
| UY35421A (en) | 2013-03-15 | 2014-10-31 | Nihon Nohyaku Co Ltd | CONDENSED HETEROCYCLIC COMPOUND OR ITS SALT, AGRICULTURAL OR HERITAGE INSECTICIDE THAT INCLUDES THE COMPOSITE AND METHOD OF USE OF THE INSECTICIDE |
| PL3089971T3 (en) * | 2014-01-01 | 2021-01-25 | Medivation Technologies Llc | Compounds and methods of use |
| US10202373B2 (en) | 2014-01-14 | 2019-02-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| CA3093189A1 (en) | 2018-03-07 | 2019-09-12 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitors |
| US11161838B2 (en) | 2018-11-13 | 2021-11-02 | Incyte Corporation | Heterocyclic derivatives as PI3K inhibitors |
| US11396502B2 (en) | 2018-11-13 | 2022-07-26 | Incyte Corporation | Substituted heterocyclic derivatives as PI3K inhibitors |
| WO2020102198A1 (en) | 2018-11-13 | 2020-05-22 | Incyte Corporation | Heterocyclic derivatives as pi3k inhibitors |
| CN111793022A (en) * | 2020-04-27 | 2020-10-20 | 滁州拜奥生物科技有限公司 | Preparation method of 3-methylquinoline |
| RU2744470C1 (en) * | 2020-09-22 | 2021-03-09 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный технический университет" (ВолгГТУ) | Method for producing isothiobarbamine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) | 1841-03-12 | Tor and planter for plowing | ||
| US992374A (en) | 1910-07-09 | 1911-05-16 | William Mcguire | Automatic block-signal joint. |
| US4788195A (en) * | 1986-01-13 | 1988-11-29 | American Cyanamid Company | 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines |
| US6723730B2 (en) | 2000-07-20 | 2004-04-20 | Neurogen Corporation | Capsaicin receptor ligands |
| CA2486376A1 (en) | 2002-05-22 | 2003-12-04 | Amgen Inc. | Amino-pyridine, -pyridine and pyridazine derivatives for use as vanilloid receptor ligands for the treatment of pain |
-
2004
- 2004-11-09 JP JP2006538935A patent/JP2007510706A/en not_active Withdrawn
- 2004-11-09 CA CA002545384A patent/CA2545384A1/en not_active Abandoned
- 2004-11-09 EP EP04798442A patent/EP1685124A1/en not_active Withdrawn
- 2004-11-09 AU AU2004289518A patent/AU2004289518A1/en not_active Abandoned
- 2004-11-09 WO PCT/GB2004/004719 patent/WO2005047279A1/en active Application Filing
- 2004-11-09 WO PCT/GB2004/004730 patent/WO2005047280A1/en active Application Filing
- 2004-11-10 TW TW093134359A patent/TW200526196A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007510706A (en) | 2007-04-26 |
| WO2005047280A1 (en) | 2005-05-26 |
| CA2545384A1 (en) | 2005-05-26 |
| EP1685124A1 (en) | 2006-08-02 |
| TW200526196A (en) | 2005-08-16 |
| AU2004289518A1 (en) | 2005-05-26 |
| WO2005047279A1 (en) | 2005-05-26 |
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