YU68502A - Piridazinil fenil hidrazoni korisni protiv kongestivnog srčanog udara - Google Patents
Piridazinil fenil hidrazoni korisni protiv kongestivnog srčanog udaraInfo
- Publication number
- YU68502A YU68502A YU68502A YUP68502A YU68502A YU 68502 A YU68502 A YU 68502A YU 68502 A YU68502 A YU 68502A YU P68502 A YUP68502 A YU P68502A YU 68502 A YU68502 A YU 68502A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- heart failure
- congestive heart
- aryl
- useful against
- arylalkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Abstract
Terapeutski aktivna jedinjenja formule (I) gde R1 do R4 označavaju vodonik, alkil, alkenil, aril, arilalkil, karboksialkil, hidroksialkil, ili halogenalkil, ili R2 i R3 obrazuju prsten od 5-7 ugljenikovih atoma, R5 do R9 označavaju vodonik, alkil, alkenil, aril, arilalkil, acil, hidroksi, alkoksi, alkoksikarbonil, amino, acilamino, alkilamino, ariloksi, halogen, cijano, nitro, karboksi, alkilsulfonil, sulfonamido ili trifluorometil, gde svaki aril ostatak definisan gore sam po sebi ili kao deo neke druge grupe može da bude supstituisan i njihove farmaceutski prihvatljive soli i estri. Jedinjenja povećavaju kalcijumsku senzitivnost kontraktilnih proteina srčanog mišića i stoga su korisni u tretiranju kongestivnog srčanog udara.[Therapeutically active compounds of formula (I) in which R1 to R4 means hydrogen, alkyl, alkenyl, aryl, arylalkyl, carboxyalkyl, hydroxyalkyl or halogenalkyl, or R2 and R3 form a ring of 5-7 carbon atoms, R5 to R9 means hydrogen, alkyl, alkenyl, aryl, arylalkyl, acyl, hydroxy, alkoxy, alkoxycarbonyl, amino, acylamino, alkylamino, aryloxy, halogen, cyano, nitro, carboxy, alkylsulfonyl, sulfonamido or trifluoromethyl, wherein each aryl residue defined above by itself or as a part of another group may be substituted, and pharmaceutically acceptable salts and esters thereof. The compounds increase the calcium sensitivity of contractile proteins of the cardiac muscle and are thus useful in the treatment of congestive heart failure.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20000577A FI20000577A0 (fi) | 2000-03-13 | 2000-03-13 | Pyridatsinyylifenyylihydratsoneja |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU68502A true YU68502A (sh) | 2005-11-28 |
| RS50439B RS50439B (sr) | 2009-12-31 |
Family
ID=8557913
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6699868B2 (sh) |
| EP (1) | EP1265871B1 (sh) |
| JP (1) | JP2003527375A (sh) |
| KR (1) | KR20030001379A (sh) |
| CN (1) | CN1191241C (sh) |
| AR (1) | AR027644A1 (sh) |
| AT (1) | ATE317388T1 (sh) |
| AU (2) | AU2001246577B2 (sh) |
| BG (1) | BG65859B1 (sh) |
| BR (1) | BR0109136A (sh) |
| CA (1) | CA2403188A1 (sh) |
| CZ (1) | CZ20022997A3 (sh) |
| DE (1) | DE60117131T2 (sh) |
| DK (1) | DK1265871T3 (sh) |
| EA (1) | EA005574B1 (sh) |
| EE (1) | EE200200520A (sh) |
| ES (1) | ES2256222T3 (sh) |
| FI (1) | FI20000577A0 (sh) |
| HK (1) | HK1052008A1 (sh) |
| HR (1) | HRP20020816A2 (sh) |
| HU (1) | HUP0300177A3 (sh) |
| IL (2) | IL151492A0 (sh) |
| MX (1) | MXPA02008997A (sh) |
| NO (1) | NO324172B1 (sh) |
| NZ (1) | NZ521162A (sh) |
| PL (1) | PL357107A1 (sh) |
| RS (1) | RS50439B (sh) |
| SI (1) | SI1265871T1 (sh) |
| SK (1) | SK287163B6 (sh) |
| UA (1) | UA74571C2 (sh) |
| WO (1) | WO2001068611A1 (sh) |
| ZA (1) | ZA200206917B (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0015228D0 (en) * | 2000-06-21 | 2000-08-16 | Portela & Ca Sa | Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders |
| JP4561698B2 (ja) * | 2002-02-19 | 2010-10-13 | 小野薬品工業株式会社 | 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
| JPWO2004087641A1 (ja) * | 2003-03-31 | 2006-06-29 | 第一製薬株式会社 | ヒドラゾン誘導体 |
| GB0503962D0 (en) | 2005-02-25 | 2005-04-06 | Kudos Pharm Ltd | Compounds |
| MX2009000884A (es) | 2006-07-25 | 2009-06-05 | Cephalon Inc | Derivados de piridizinona. |
| US20100286150A1 (en) | 2007-01-17 | 2010-11-11 | Fia Westerholm | Levosimendan for use in treating chronic valvular disease |
| JP6123673B2 (ja) * | 2011-09-27 | 2017-05-10 | 日本ゼオン株式会社 | 重合性化合物の製造中間体及びその製造方法 |
| ES2684776T3 (es) * | 2013-01-18 | 2018-10-04 | Bristol-Myers Squibb Company | Ftalazinonas e isoquinolinonas como inhibidores de ROCK |
| JPWO2019235569A1 (ja) * | 2018-06-08 | 2021-07-08 | 日産化学株式会社 | キナーゼ阻害剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3531658A1 (de) | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel |
| US5185332A (en) * | 1989-02-11 | 1993-02-09 | Orion-Yhtyma Oy | Thiadiazines and pharmaceutical compositions thereof as well as method of use |
| GB8903130D0 (en) | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
| FI973804A (fi) * | 1997-09-26 | 1999-03-27 | Orion Yhtymae Oy | Levosimendaanin oraalisia koostumuksia |
-
2000
- 2000-03-13 FI FI20000577A patent/FI20000577A0/fi unknown
-
2001
- 2001-03-12 CA CA002403188A patent/CA2403188A1/en not_active Abandoned
- 2001-03-12 DE DE60117131T patent/DE60117131T2/de not_active Expired - Fee Related
- 2001-03-12 IL IL15149201A patent/IL151492A0/xx active IP Right Grant
- 2001-03-12 RS YUP-685/02A patent/RS50439B/sr unknown
- 2001-03-12 WO PCT/FI2001/000241 patent/WO2001068611A1/en active IP Right Grant
- 2001-03-12 AR ARP010101149A patent/AR027644A1/es unknown
- 2001-03-12 EP EP01919489A patent/EP1265871B1/en not_active Expired - Lifetime
- 2001-03-12 EE EEP200200520A patent/EE200200520A/xx unknown
- 2001-03-12 JP JP2001567705A patent/JP2003527375A/ja not_active Withdrawn
- 2001-03-12 AT AT01919489T patent/ATE317388T1/de not_active IP Right Cessation
- 2001-03-12 ES ES01919489T patent/ES2256222T3/es not_active Expired - Lifetime
- 2001-03-12 EA EA200200973A patent/EA005574B1/ru not_active IP Right Cessation
- 2001-03-12 BR BR0109136-0A patent/BR0109136A/pt not_active IP Right Cessation
- 2001-03-12 SI SI200130518T patent/SI1265871T1/sl unknown
- 2001-03-12 CZ CZ20022997A patent/CZ20022997A3/cs unknown
- 2001-03-12 SK SK1288-2002A patent/SK287163B6/sk not_active IP Right Cessation
- 2001-03-12 NZ NZ521162A patent/NZ521162A/en unknown
- 2001-03-12 KR KR1020027012066A patent/KR20030001379A/ko not_active Application Discontinuation
- 2001-03-12 DK DK01919489T patent/DK1265871T3/da active
- 2001-03-12 MX MXPA02008997A patent/MXPA02008997A/es active IP Right Grant
- 2001-03-12 AU AU2001246577A patent/AU2001246577B2/en not_active Ceased
- 2001-03-12 CN CNB018065309A patent/CN1191241C/zh not_active Expired - Fee Related
- 2001-03-12 AU AU4657701A patent/AU4657701A/xx active Pending
- 2001-03-12 US US10/221,348 patent/US6699868B2/en not_active Expired - Fee Related
- 2001-03-12 HU HU0300177A patent/HUP0300177A3/hu unknown
- 2001-03-12 PL PL01357107A patent/PL357107A1/xx not_active Application Discontinuation
- 2001-12-03 UA UA2002108100A patent/UA74571C2/uk unknown
-
2002
- 2002-08-26 IL IL151492A patent/IL151492A/en not_active IP Right Cessation
- 2002-08-28 ZA ZA200206917A patent/ZA200206917B/en unknown
- 2002-09-05 NO NO20024247A patent/NO324172B1/no not_active IP Right Cessation
- 2002-10-08 BG BG107175A patent/BG65859B1/bg unknown
- 2002-10-11 HR HRP20020816 patent/HRP20020816A2/hr not_active Application Discontinuation
-
2003
- 2003-06-16 HK HK03104272A patent/HK1052008A1/xx not_active IP Right Cessation
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