JP2003527375A - うっ血性心不全に対して有用なピリダジニルフェニルヒドラゾン - Google Patents

うっ血性心不全に対して有用なピリダジニルフェニルヒドラゾン

Info

Publication number
JP2003527375A
JP2003527375A JP2001567705A JP2001567705A JP2003527375A JP 2003527375 A JP2003527375 A JP 2003527375A JP 2001567705 A JP2001567705 A JP 2001567705A JP 2001567705 A JP2001567705 A JP 2001567705A JP 2003527375 A JP2003527375 A JP 2003527375A
Authority
JP
Japan
Prior art keywords
methyl
hydrogen
phenyl
alkyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001567705A
Other languages
English (en)
Japanese (ja)
Inventor
ピュステュネン、ヤルモ
ピップリ、アイノ
ルイロ、アンネ
ノレ、ペンチ
ベックストレーム、レイヨ
レンベルグ、カリ
ハイカラ、ヘイモ
レビヨキ、ヨウコ
カヘイネン、ペトリ
カイボラ、ユハ
Original Assignee
オリオン コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オリオン コーポレーション filed Critical オリオン コーポレーション
Publication of JP2003527375A publication Critical patent/JP2003527375A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2001567705A 2000-03-13 2001-03-12 うっ血性心不全に対して有用なピリダジニルフェニルヒドラゾン Withdrawn JP2003527375A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20000577A FI20000577A0 (fi) 2000-03-13 2000-03-13 Pyridatsinyylifenyylihydratsoneja
FI20000577 2000-03-13
PCT/FI2001/000241 WO2001068611A1 (en) 2000-03-13 2001-03-12 Pyridazinyl phenyl hydrazones useful against congestive heart failure

Publications (1)

Publication Number Publication Date
JP2003527375A true JP2003527375A (ja) 2003-09-16

Family

ID=8557913

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001567705A Withdrawn JP2003527375A (ja) 2000-03-13 2001-03-12 うっ血性心不全に対して有用なピリダジニルフェニルヒドラゾン

Country Status (32)

Country Link
US (1) US6699868B2 (sh)
EP (1) EP1265871B1 (sh)
JP (1) JP2003527375A (sh)
KR (1) KR20030001379A (sh)
CN (1) CN1191241C (sh)
AR (1) AR027644A1 (sh)
AT (1) ATE317388T1 (sh)
AU (2) AU4657701A (sh)
BG (1) BG65859B1 (sh)
BR (1) BR0109136A (sh)
CA (1) CA2403188A1 (sh)
CZ (1) CZ20022997A3 (sh)
DE (1) DE60117131T2 (sh)
DK (1) DK1265871T3 (sh)
EA (1) EA005574B1 (sh)
EE (1) EE200200520A (sh)
ES (1) ES2256222T3 (sh)
FI (1) FI20000577A0 (sh)
HK (1) HK1052008A1 (sh)
HR (1) HRP20020816A2 (sh)
HU (1) HUP0300177A3 (sh)
IL (2) IL151492A0 (sh)
MX (1) MXPA02008997A (sh)
NO (1) NO324172B1 (sh)
NZ (1) NZ521162A (sh)
PL (1) PL357107A1 (sh)
RS (1) RS50439B (sh)
SI (1) SI1265871T1 (sh)
SK (1) SK287163B6 (sh)
UA (1) UA74571C2 (sh)
WO (1) WO2001068611A1 (sh)
ZA (1) ZA200206917B (sh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2013046781A1 (ja) * 2011-09-27 2015-03-26 日本ゼオン株式会社 重合性化合物の製造中間体及びその製造方法
JP2016505042A (ja) * 2013-01-18 2016-02-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｒｏｃｋ阻害剤としてのフタラジノンおよびイソキノリノン

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015228D0 (en) * 2000-06-21 2000-08-16 Portela & Ca Sa Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders
JP4561698B2 (ja) * 2002-02-19 2010-10-13 小野薬品工業株式会社 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤
EP1612204A4 (en) * 2003-03-31 2007-04-11 Daiichi Seiyaku Co HYDRAZONE DERIVATIVE
GB0503962D0 (en) 2005-02-25 2005-04-06 Kudos Pharm Ltd Compounds
WO2008013838A2 (en) 2006-07-25 2008-01-31 Cephalon, Inc. Pyridizinone derivatives
US20100286150A1 (en) 2007-01-17 2010-11-11 Fia Westerholm Levosimendan for use in treating chronic valvular disease
JPWO2019235569A1 (ja) * 2018-06-08 2021-07-08 日産化学株式会社 キナーゼ阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531658A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
US5185332A (en) * 1989-02-11 1993-02-09 Orion-Yhtyma Oy Thiadiazines and pharmaceutical compositions thereof as well as method of use
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2013046781A1 (ja) * 2011-09-27 2015-03-26 日本ゼオン株式会社 重合性化合物の製造中間体及びその製造方法
JP2019032548A (ja) * 2011-09-27 2019-02-28 日本ゼオン株式会社 重合性化合物を製造する製造方法
JP2016505042A (ja) * 2013-01-18 2016-02-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｒｏｃｋ阻害剤としてのフタラジノンおよびイソキノリノン
JP2019073521A (ja) * 2013-01-18 2019-05-16 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｒｏｃｋ阻害剤としてのフタラジノンおよびイソキノリノン
JP2019077689A (ja) * 2013-01-18 2019-05-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｒｏｃｋ阻害剤としてのフタラジノンおよびイソキノリノン

Also Published As

Publication number Publication date
US6699868B2 (en) 2004-03-02
HUP0300177A2 (hu) 2003-07-28
ES2256222T3 (es) 2006-07-16
WO2001068611A1 (en) 2001-09-20
DK1265871T3 (da) 2006-06-06
EP1265871B1 (en) 2006-02-08
HUP0300177A3 (en) 2003-09-29
NO324172B1 (no) 2007-09-03
BR0109136A (pt) 2002-12-24
NO20024247D0 (no) 2002-09-05
YU68502A (sh) 2005-11-28
NO20024247L (no) 2002-10-25
FI20000577A0 (fi) 2000-03-13
ZA200206917B (en) 2003-07-30
NZ521162A (en) 2003-11-28
AU4657701A (en) 2001-09-24
PL357107A1 (en) 2004-07-12
KR20030001379A (ko) 2003-01-06
CZ20022997A3 (cs) 2003-04-16
CN1418196A (zh) 2003-05-14
SK12882002A3 (sk) 2003-06-03
CN1191241C (zh) 2005-03-02
AU2001246577B2 (en) 2006-08-31
BG65859B1 (bg) 2010-03-31
MXPA02008997A (es) 2003-04-25
SK287163B6 (sk) 2010-02-08
RS50439B (sr) 2009-12-31
SI1265871T1 (sl) 2006-06-30
CA2403188A1 (en) 2001-09-20
AR027644A1 (es) 2003-04-09
HRP20020816A2 (en) 2004-12-31
US20030158200A1 (en) 2003-08-21
EA200200973A1 (ru) 2003-02-27
IL151492A (en) 2007-09-20
ATE317388T1 (de) 2006-02-15
DE60117131T2 (de) 2006-10-26
DE60117131D1 (de) 2006-04-20
HK1052008A1 (en) 2003-08-29
IL151492A0 (en) 2003-04-10
UA74571C2 (en) 2006-01-16
BG107175A (bg) 2003-05-30
EA005574B1 (ru) 2005-04-28
EE200200520A (et) 2004-04-15
EP1265871A1 (en) 2002-12-18

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