CA2403188A1 - Pyridazinyl phenyl hydrazones useful against congestive heart failure - Google Patents

Pyridazinyl phenyl hydrazones useful against congestive heart failure Download PDF

Info

Publication number
CA2403188A1
CA2403188A1 CA002403188A CA2403188A CA2403188A1 CA 2403188 A1 CA2403188 A1 CA 2403188A1 CA 002403188 A CA002403188 A CA 002403188A CA 2403188 A CA2403188 A CA 2403188A CA 2403188 A1 CA2403188 A1 CA 2403188A1
Authority
CA
Canada
Prior art keywords
methyl
phenyl
pyridazin
hydroxy
dmso
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002403188A
Other languages
English (en)
French (fr)
Inventor
Jarmo Pystynen
Aino Pippuri
Anne Luiro
Pentti Nore
Reijo Backstrom
Kari Lonnberg
Heimo Haikala
Jouko Levijoki
Petri Kaheinen
Juha Kaivola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Corporation
Jarmo Pystynen
Aino Pippuri
Anne Luiro
Pentti Nore
Reijo Backstrom
Kari Lonnberg
Heimo Haikala
Jouko Levijoki
Petri Kaheinen
Juha Kaivola
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation, Jarmo Pystynen, Aino Pippuri, Anne Luiro, Pentti Nore, Reijo Backstrom, Kari Lonnberg, Heimo Haikala, Jouko Levijoki, Petri Kaheinen, Juha Kaivola filed Critical Orion Corporation
Publication of CA2403188A1 publication Critical patent/CA2403188A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002403188A 2000-03-13 2001-03-12 Pyridazinyl phenyl hydrazones useful against congestive heart failure Abandoned CA2403188A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20000577A FI20000577A0 (fi) 2000-03-13 2000-03-13 Pyridatsinyylifenyylihydratsoneja
FI20000577 2000-03-13
PCT/FI2001/000241 WO2001068611A1 (en) 2000-03-13 2001-03-12 Pyridazinyl phenyl hydrazones useful against congestive heart failure

Publications (1)

Publication Number Publication Date
CA2403188A1 true CA2403188A1 (en) 2001-09-20

Family

ID=8557913

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002403188A Abandoned CA2403188A1 (en) 2000-03-13 2001-03-12 Pyridazinyl phenyl hydrazones useful against congestive heart failure

Country Status (32)

Country Link
US (1) US6699868B2 (sh)
EP (1) EP1265871B1 (sh)
JP (1) JP2003527375A (sh)
KR (1) KR20030001379A (sh)
CN (1) CN1191241C (sh)
AR (1) AR027644A1 (sh)
AT (1) ATE317388T1 (sh)
AU (2) AU4657701A (sh)
BG (1) BG65859B1 (sh)
BR (1) BR0109136A (sh)
CA (1) CA2403188A1 (sh)
CZ (1) CZ20022997A3 (sh)
DE (1) DE60117131T2 (sh)
DK (1) DK1265871T3 (sh)
EA (1) EA005574B1 (sh)
EE (1) EE200200520A (sh)
ES (1) ES2256222T3 (sh)
FI (1) FI20000577A0 (sh)
HK (1) HK1052008A1 (sh)
HR (1) HRP20020816A2 (sh)
HU (1) HUP0300177A3 (sh)
IL (2) IL151492A0 (sh)
MX (1) MXPA02008997A (sh)
NO (1) NO324172B1 (sh)
NZ (1) NZ521162A (sh)
PL (1) PL357107A1 (sh)
RS (1) RS50439B (sh)
SI (1) SI1265871T1 (sh)
SK (1) SK287163B6 (sh)
UA (1) UA74571C2 (sh)
WO (1) WO2001068611A1 (sh)
ZA (1) ZA200206917B (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015228D0 (en) * 2000-06-21 2000-08-16 Portela & Ca Sa Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders
JP4561698B2 (ja) * 2002-02-19 2010-10-13 小野薬品工業株式会社 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤
EP1612204A4 (en) * 2003-03-31 2007-04-11 Daiichi Seiyaku Co HYDRAZONE DERIVATIVE
GB0503962D0 (en) 2005-02-25 2005-04-06 Kudos Pharm Ltd Compounds
WO2008013838A2 (en) 2006-07-25 2008-01-31 Cephalon, Inc. Pyridizinone derivatives
US20100286150A1 (en) 2007-01-17 2010-11-11 Fia Westerholm Levosimendan for use in treating chronic valvular disease
EP2762465B1 (en) * 2011-09-27 2018-01-10 Zeon Corporation Intermediate for manufacture of polymerizable compound and process for manufacture thereof
ES2684776T3 (es) * 2013-01-18 2018-10-04 Bristol-Myers Squibb Company Ftalazinonas e isoquinolinonas como inhibidores de ROCK
JPWO2019235569A1 (ja) * 2018-06-08 2021-07-08 日産化学株式会社 キナーゼ阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531658A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
US5185332A (en) * 1989-02-11 1993-02-09 Orion-Yhtyma Oy Thiadiazines and pharmaceutical compositions thereof as well as method of use
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Also Published As

Publication number Publication date
JP2003527375A (ja) 2003-09-16
US6699868B2 (en) 2004-03-02
HUP0300177A2 (hu) 2003-07-28
ES2256222T3 (es) 2006-07-16
WO2001068611A1 (en) 2001-09-20
DK1265871T3 (da) 2006-06-06
EP1265871B1 (en) 2006-02-08
HUP0300177A3 (en) 2003-09-29
NO324172B1 (no) 2007-09-03
BR0109136A (pt) 2002-12-24
NO20024247D0 (no) 2002-09-05
YU68502A (sh) 2005-11-28
NO20024247L (no) 2002-10-25
FI20000577A0 (fi) 2000-03-13
ZA200206917B (en) 2003-07-30
NZ521162A (en) 2003-11-28
AU4657701A (en) 2001-09-24
PL357107A1 (en) 2004-07-12
KR20030001379A (ko) 2003-01-06
CZ20022997A3 (cs) 2003-04-16
CN1418196A (zh) 2003-05-14
SK12882002A3 (sk) 2003-06-03
CN1191241C (zh) 2005-03-02
AU2001246577B2 (en) 2006-08-31
BG65859B1 (bg) 2010-03-31
MXPA02008997A (es) 2003-04-25
SK287163B6 (sk) 2010-02-08
RS50439B (sr) 2009-12-31
SI1265871T1 (sl) 2006-06-30
AR027644A1 (es) 2003-04-09
HRP20020816A2 (en) 2004-12-31
US20030158200A1 (en) 2003-08-21
EA200200973A1 (ru) 2003-02-27
IL151492A (en) 2007-09-20
ATE317388T1 (de) 2006-02-15
DE60117131T2 (de) 2006-10-26
DE60117131D1 (de) 2006-04-20
HK1052008A1 (en) 2003-08-29
IL151492A0 (en) 2003-04-10
UA74571C2 (en) 2006-01-16
BG107175A (bg) 2003-05-30
EA005574B1 (ru) 2005-04-28
EE200200520A (et) 2004-04-15
EP1265871A1 (en) 2002-12-18

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued