BR0109136A - Hidrazonas de fenila piridazinila úteis contra insuficiência cardìaca congestiva - Google Patents

Hidrazonas de fenila piridazinila úteis contra insuficiência cardìaca congestiva

Info

Publication number
BR0109136A
BR0109136A BR0109136-0A BR0109136A BR0109136A BR 0109136 A BR0109136 A BR 0109136A BR 0109136 A BR0109136 A BR 0109136A BR 0109136 A BR0109136 A BR 0109136A
Authority
BR
Brazil
Prior art keywords
congestive heart
heart failure
aryl
arylalkyl
alkenyl
Prior art date
Application number
BR0109136-0A
Other languages
English (en)
Inventor
Jarmo Pystynen
Aino Pippuri
Anne Luiro
Pentti Nore
Bockstr M Reijo
Kari L Nnberg
Heimo Haikala
Jouko Levijoki
Petrik Kaheinen
Juha Kaivola
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of BR0109136A publication Critical patent/BR0109136A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"HIDRAZONAS DE FENILA PIRIDAZINILA úTEIS CONTRA INSUFICIêNCIA CARDìACA CONGESTIVA". Compostos ativos terapeuticamente de fórmula (I), na qual R~ 1~ a R~ 4~, significa hidrogênio, alquila, alquenila, arila, arilalquila, carboxialquila, hidróxialquila ou halogenoalquila, ou R~ 2~ e R~ 3~ formam um anel de 5-7 átomos de carbono, R~ 5~ a R~ 9~ significa hidrogênio, alquila, alquenila, arila, arilalquila, acila, hidróxi, alcóxi, alcóxicarbonila, amino, acilamino, alquilamino, arilóxi, halogênio, ciano, nitro, carbóxi, alquilsulfonila, sulfonamido ou triflúormetila, em que cada resíduo de arila definido acima por si só ou como uma parte de outro grupo pode ser substituído, e sais farmaceuticamente aceitáveis e ésteres destes. Os compostos aumentam a sensibilidade de cálcio das proteínas contrácteis do músculo cardíaco e são então úteis no tratamento de insuficiência cardíaca congestiva.
BR0109136-0A 2000-03-13 2001-03-12 Hidrazonas de fenila piridazinila úteis contra insuficiência cardìaca congestiva BR0109136A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20000577A FI20000577A0 (fi) 2000-03-13 2000-03-13 Pyridatsinyylifenyylihydratsoneja
PCT/FI2001/000241 WO2001068611A1 (en) 2000-03-13 2001-03-12 Pyridazinyl phenyl hydrazones useful against congestive heart failure

Publications (1)

Publication Number Publication Date
BR0109136A true BR0109136A (pt) 2002-12-24

Family

ID=8557913

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109136-0A BR0109136A (pt) 2000-03-13 2001-03-12 Hidrazonas de fenila piridazinila úteis contra insuficiência cardìaca congestiva

Country Status (32)

Country Link
US (1) US6699868B2 (pt)
EP (1) EP1265871B1 (pt)
JP (1) JP2003527375A (pt)
KR (1) KR20030001379A (pt)
CN (1) CN1191241C (pt)
AR (1) AR027644A1 (pt)
AT (1) ATE317388T1 (pt)
AU (2) AU4657701A (pt)
BG (1) BG65859B1 (pt)
BR (1) BR0109136A (pt)
CA (1) CA2403188A1 (pt)
CZ (1) CZ20022997A3 (pt)
DE (1) DE60117131T2 (pt)
DK (1) DK1265871T3 (pt)
EA (1) EA005574B1 (pt)
EE (1) EE200200520A (pt)
ES (1) ES2256222T3 (pt)
FI (1) FI20000577A0 (pt)
HK (1) HK1052008A1 (pt)
HR (1) HRP20020816A2 (pt)
HU (1) HUP0300177A3 (pt)
IL (2) IL151492A0 (pt)
MX (1) MXPA02008997A (pt)
NO (1) NO324172B1 (pt)
NZ (1) NZ521162A (pt)
PL (1) PL357107A1 (pt)
RS (1) RS50439B (pt)
SI (1) SI1265871T1 (pt)
SK (1) SK287163B6 (pt)
UA (1) UA74571C2 (pt)
WO (1) WO2001068611A1 (pt)
ZA (1) ZA200206917B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015228D0 (en) * 2000-06-21 2000-08-16 Portela & Ca Sa Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders
JP4561698B2 (ja) * 2002-02-19 2010-10-13 小野薬品工業株式会社 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤
US20060276433A1 (en) * 2003-03-31 2006-12-07 Keiichi Kawagoe Hydrazone derivative
GB0503962D0 (en) 2005-02-25 2005-04-06 Kudos Pharm Ltd Compounds
PL2069312T3 (pl) 2006-07-25 2013-03-29 Cephalon Inc Pochodne pirydazynonu
CA2675176A1 (en) 2007-01-17 2008-07-24 Orion Corporation Levosimendan for use in treating chronic valvular disease
KR20200024367A (ko) * 2011-09-27 2020-03-06 제온 코포레이션 중합성 화합물의 제조 중간체 및 그 제조 방법
TW201443023A (zh) * 2013-01-18 2014-11-16 必治妥美雅史谷比公司 作爲ｒｏｃｋ抑制劑之酞□酮及異喹啉酮
WO2019235569A1 (ja) * 2018-06-08 2019-12-12 日産化学株式会社 キナーゼ阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531658A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
US5185332A (en) * 1989-02-11 1993-02-09 Orion-Yhtyma Oy Thiadiazines and pharmaceutical compositions thereof as well as method of use
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Also Published As

Publication number Publication date
IL151492A (en) 2007-09-20
US6699868B2 (en) 2004-03-02
CZ20022997A3 (cs) 2003-04-16
UA74571C2 (en) 2006-01-16
IL151492A0 (en) 2003-04-10
BG65859B1 (bg) 2010-03-31
ZA200206917B (en) 2003-07-30
EP1265871A1 (en) 2002-12-18
HK1052008A1 (en) 2003-08-29
NO324172B1 (no) 2007-09-03
MXPA02008997A (es) 2003-04-25
RS50439B (sr) 2009-12-31
EA005574B1 (ru) 2005-04-28
SK12882002A3 (sk) 2003-06-03
NO20024247L (no) 2002-10-25
CN1191241C (zh) 2005-03-02
NO20024247D0 (no) 2002-09-05
EE200200520A (et) 2004-04-15
SI1265871T1 (sl) 2006-06-30
EA200200973A1 (ru) 2003-02-27
JP2003527375A (ja) 2003-09-16
AU4657701A (en) 2001-09-24
FI20000577A0 (fi) 2000-03-13
KR20030001379A (ko) 2003-01-06
DK1265871T3 (da) 2006-06-06
NZ521162A (en) 2003-11-28
DE60117131T2 (de) 2006-10-26
HUP0300177A3 (en) 2003-09-29
SK287163B6 (sk) 2010-02-08
HRP20020816A2 (en) 2004-12-31
AU2001246577B2 (en) 2006-08-31
YU68502A (sh) 2005-11-28
ATE317388T1 (de) 2006-02-15
PL357107A1 (en) 2004-07-12
US20030158200A1 (en) 2003-08-21
HUP0300177A2 (hu) 2003-07-28
EP1265871B1 (en) 2006-02-08
WO2001068611A1 (en) 2001-09-20
AR027644A1 (es) 2003-04-09
BG107175A (bg) 2003-05-30
CN1418196A (zh) 2003-05-14
CA2403188A1 (en) 2001-09-20
ES2256222T3 (es) 2006-07-16
DE60117131D1 (de) 2006-04-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A E 11A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.