AR031627A1 - Activadores heteroaromaticos fusionados de la glucoquinasa - Google Patents

Activadores heteroaromaticos fusionados de la glucoquinasa

Info

Publication number
AR031627A1
AR031627A1 ARP010105639A ARP010105639A AR031627A1 AR 031627 A1 AR031627 A1 AR 031627A1 AR P010105639 A ARP010105639 A AR P010105639A AR P010105639 A ARP010105639 A AR P010105639A AR 031627 A1 AR031627 A1 AR 031627A1
Authority
AR
Argentina
Prior art keywords
glucoquinasa
fusioned
heteroaromatic
activators
halo
Prior art date
Application number
ARP010105639A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR031627A1 publication Critical patent/AR031627A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Los compuestos activadores de la glucoquinasa o las sales farmacéuticamente aceptables de formula (1): en donde M es formulas (2) o (3), Q es formulas (4) o (5), R1 es un alquilo con C1-3; R2 es hidrogeno, halo, nitro, ciano, o perfluoro-metilo; R3 es un cicloalquilo con C4-7 o 2-propilo; R5 es halogeno; R6 es halogeno; W es O, S o NH; cada Y es independientemente CH o N; Z es ûCH2-CH2-CH2-CH2- o ûCH=CR4-CH=CH-, en donde R4 es hidrogeno, halo o una alquil sulfona con C1-3; y las líneas de puntos colectivamente representan 0 o 2 dobles enlaces adicionales en la estructura del anillo heterocíclico. Los compuestos de formula (1) también se pueden presentar en forma de racemato o en la configuracion "R" aislada en el carbono asimétrico mostrado.
ARP010105639A 2000-12-06 2001-12-04 Activadores heteroaromaticos fusionados de la glucoquinasa AR031627A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25163700P 2000-12-06 2000-12-06

Publications (1)

Publication Number Publication Date
AR031627A1 true AR031627A1 (es) 2003-09-24

Family

ID=22952803

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105639A AR031627A1 (es) 2000-12-06 2001-12-04 Activadores heteroaromaticos fusionados de la glucoquinasa

Country Status (21)

Country Link
US (3) US6441184B1 (es)
EP (1) EP1341774B1 (es)
JP (1) JP4109111B2 (es)
KR (1) KR100545431B1 (es)
CN (1) CN1226294C (es)
AR (1) AR031627A1 (es)
AT (1) ATE316965T1 (es)
AU (2) AU2190202A (es)
BR (1) BR0115999A (es)
CA (1) CA2429642C (es)
DE (1) DE60117059T2 (es)
DK (1) DK1341774T3 (es)
ES (1) ES2256340T3 (es)
GT (1) GT200100243A (es)
MX (1) MXPA03005119A (es)
PA (1) PA8534301A1 (es)
PE (1) PE20020753A1 (es)
PT (1) PT1341774E (es)
UY (1) UY27055A1 (es)
WO (1) WO2002046173A1 (es)
ZA (1) ZA200303748B (es)

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Also Published As

Publication number Publication date
CN1476438A (zh) 2004-02-18
WO2002046173A1 (en) 2002-06-13
PA8534301A1 (es) 2002-08-26
CA2429642A1 (en) 2002-06-13
AU2190202A (en) 2002-06-18
US20020103241A1 (en) 2002-08-01
CA2429642C (en) 2007-11-20
GT200100243A (es) 2002-06-04
JP2004517087A (ja) 2004-06-10
KR100545431B1 (ko) 2006-01-24
CN1226294C (zh) 2005-11-09
PE20020753A1 (es) 2002-08-27
US20020107396A1 (en) 2002-08-08
EP1341774A1 (en) 2003-09-10
ES2256340T3 (es) 2006-07-16
US20020103199A1 (en) 2002-08-01
US6441184B1 (en) 2002-08-27
KR20030068555A (ko) 2003-08-21
US6545155B2 (en) 2003-04-08
ATE316965T1 (de) 2006-02-15
BR0115999A (pt) 2003-09-30
DK1341774T3 (da) 2006-06-12
PT1341774E (pt) 2006-05-31
ZA200303748B (en) 2004-08-16
US6448399B1 (en) 2002-09-10
JP4109111B2 (ja) 2008-07-02
DE60117059D1 (de) 2006-04-13
EP1341774B1 (en) 2006-02-01
MXPA03005119A (es) 2004-10-15
AU2002221902B2 (en) 2006-11-23
UY27055A1 (es) 2002-07-31
DE60117059T2 (de) 2006-10-26

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