DK1341774T3 - Kondenserede heteroaromatiske glucokinase-aktivatorer - Google Patents
Kondenserede heteroaromatiske glucokinase-aktivatorerInfo
- Publication number
- DK1341774T3 DK1341774T3 DK01999565T DK01999565T DK1341774T3 DK 1341774 T3 DK1341774 T3 DK 1341774T3 DK 01999565 T DK01999565 T DK 01999565T DK 01999565 T DK01999565 T DK 01999565T DK 1341774 T3 DK1341774 T3 DK 1341774T3
- Authority
- DK
- Denmark
- Prior art keywords
- glucokinase activators
- condensed heteroaromatic
- heteroaromatic glucokinase
- condensed
- activators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25163700P | 2000-12-06 | 2000-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1341774T3 true DK1341774T3 (da) | 2006-06-12 |
Family
ID=22952803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01999565T DK1341774T3 (da) | 2000-12-06 | 2001-11-28 | Kondenserede heteroaromatiske glucokinase-aktivatorer |
Country Status (21)
Country | Link |
---|---|
US (3) | US6448399B1 (da) |
EP (1) | EP1341774B1 (da) |
JP (1) | JP4109111B2 (da) |
KR (1) | KR100545431B1 (da) |
CN (1) | CN1226294C (da) |
AR (1) | AR031627A1 (da) |
AT (1) | ATE316965T1 (da) |
AU (2) | AU2002221902B2 (da) |
BR (1) | BR0115999A (da) |
CA (1) | CA2429642C (da) |
DE (1) | DE60117059T2 (da) |
DK (1) | DK1341774T3 (da) |
ES (1) | ES2256340T3 (da) |
GT (1) | GT200100243A (da) |
MX (1) | MXPA03005119A (da) |
PA (1) | PA8534301A1 (da) |
PE (1) | PE20020753A1 (da) |
PT (1) | PT1341774E (da) |
UY (1) | UY27055A1 (da) |
WO (1) | WO2002046173A1 (da) |
ZA (1) | ZA200303748B (da) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
KR101116627B1 (ko) * | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
KR101124245B1 (ko) | 2002-06-27 | 2012-07-02 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
US6775812B2 (en) * | 2002-07-17 | 2004-08-10 | Hewlett-Packard Development Company, L.P. | Layout design process and system for providing bypass capacitance and compliant density in an integrated circuit |
NZ539013A (en) * | 2002-10-03 | 2007-05-31 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
CA2499329C (en) | 2002-10-03 | 2009-04-21 | F. Hoffmann-La Roche Ag | Indole-3-carboxamides as glucokinase (gk) activators |
GB0226931D0 (en) * | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
US7132425B2 (en) | 2002-12-12 | 2006-11-07 | Hoffmann-La Roche Inc. | 5-substituted-six-membered heteroaromatic glucokinase activators |
PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
JP4621198B2 (ja) * | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ(シクロ)置換アミドグルコキナーゼ活性化化合物 |
MXPA05013733A (es) * | 2003-06-20 | 2006-03-08 | Hoffmann La Roche | 2-aminobenzotiazoles como agonistas inversos del receptor de cb1. |
JP4834840B2 (ja) | 2004-01-06 | 2011-12-14 | ノヴォ ノルディスク アー/エス | ヘテロアリール尿素およびグルコキナーゼ活性化剤としてのその使用 |
US20080280872A1 (en) * | 2004-02-18 | 2008-11-13 | Craig Johnstone | Benzamide Derivatives and Their Use as Glucokinase Activating Agents |
US20080312207A1 (en) * | 2004-02-18 | 2008-12-18 | Craig Johnstone | Compounds |
CN101098876A (zh) * | 2004-04-02 | 2008-01-02 | 诺瓦提斯公司 | 噻唑并吡啶衍生物、包含它们的药物形式以及治疗葡糖激酶介导的病症的方法 |
WO2005095418A1 (en) * | 2004-04-02 | 2005-10-13 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of type 2 diabetes |
MXPA06012008A (es) * | 2004-04-21 | 2007-01-25 | Prosidion Ltd | Compuestos de amida tri(ciclo) sustituidos. |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
US7745491B2 (en) | 2004-08-12 | 2010-06-29 | Prosidion Limited | Substituted phenylacetamides and their use as glucokinase activators |
MX2007004560A (es) | 2004-10-16 | 2007-06-08 | Astrazeneca Ab | Proceso para hacer compuestos de fenoxi benzamida. |
GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
WO2006049304A1 (ja) * | 2004-11-02 | 2006-05-11 | Banyu Pharmaceutical Co., Ltd | アリールオキシ置換ベンズイミダゾール誘導体 |
DE102005012872A1 (de) * | 2005-03-19 | 2006-09-28 | Sanofi-Aventis Deutschland Gmbh | Substituierte, bizyklische 8-Pyrrolidino-benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP1891069A1 (en) * | 2005-05-24 | 2008-02-27 | AstraZeneca AB | 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
BRPI0622261A2 (pt) * | 2005-07-09 | 2011-08-09 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto |
EP1910350A1 (en) * | 2005-07-09 | 2008-04-16 | AstraZeneca AB | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
US20080234273A1 (en) * | 2005-07-09 | 2008-09-25 | Mckerrecher Darren | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes |
JP5281287B2 (ja) | 2005-07-13 | 2013-09-04 | Msd株式会社 | ヘテロ環置換ベンズイミダゾール誘導体 |
US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
CN101272784A (zh) | 2005-09-29 | 2008-09-24 | 塞诺菲-安万特股份有限公司 | 苯基-和吡啶基-1,2,4-噁二唑酮衍生物、它们的制备方法和它们作为药物的用途 |
GT200600428A (es) * | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
GT200600429A (es) * | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
CA2626475A1 (en) * | 2005-11-03 | 2007-05-10 | Prosidion Limited | Tricyclo substituted amides |
JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
AT503354B1 (de) * | 2006-02-22 | 2008-07-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen |
JP5302012B2 (ja) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
JP5386350B2 (ja) | 2006-05-31 | 2014-01-15 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤としての、インダゾールおよびイソインドール誘導体 |
US7888504B2 (en) | 2006-07-06 | 2011-02-15 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
WO2008012227A2 (en) | 2006-07-24 | 2008-01-31 | F. Hoffmann-La Roche Ag | Pyrazoles as glucokinase activators |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
SA07280576B1 (ar) * | 2006-10-26 | 2011-06-22 | استرازينيكا ايه بي | مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز |
EP2091947A2 (en) | 2006-12-20 | 2009-08-26 | Takeda San Diego, Inc. | Glucokinase activators |
US20100094009A1 (en) * | 2006-12-21 | 2010-04-15 | Mccabe James | Novel crystalline compound useful as glk activator |
TW200831081A (en) * | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
BRPI0808267A2 (pt) | 2007-03-07 | 2014-07-22 | Kyorin Phamaceutical Co., Ltd | "composto representado pela formula geral (1) ou um sal farmeceuticamente aceitável do mesmo; método para o tratamento ou prevenção de diabetes ; uso do composto; composição farmacêutica e composto representado pela formula geral (3)". |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
AR070107A1 (es) * | 2008-01-15 | 2010-03-17 | Lilly Co Eli | R-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida en forma cristalina, composicion farmaceutica que la comprende y su uso para la manufactura de un medicamento util para la prevencion o tratamiento de hiperglicemia |
EP2236498A4 (en) * | 2008-01-18 | 2012-02-22 | Astellas Pharma Inc | PHENYLACETAMIDE DERIVATIVE |
US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
PT2275414E (pt) | 2008-04-28 | 2015-09-09 | Teijin Pharma Ltd | Derivado de amida do ácido ciclopentacrílico |
MX2011001333A (es) | 2008-08-04 | 2011-03-15 | Astrazeneca Ab | Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad. |
EP2331498B1 (en) | 2008-08-19 | 2016-11-09 | Janssen Pharmaceutica NV | Cold menthol receptor antagonists |
GEP20135793B (en) | 2008-09-11 | 2013-03-25 | Pfizer | Heteroaryls amide derivatives and their use as glucokinase activators |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
AU2010222589B2 (en) | 2009-03-11 | 2012-08-16 | Pfizer Inc. | Benzofuranyl derivatives used as glucokinase inhibitors |
WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
WO2010116176A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
US8222416B2 (en) * | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
ES2489297B1 (es) | 2013-01-22 | 2015-06-10 | Consejo Superior De Investigaciones Científicas (Csic) | Benzotiazoles sustituidos y sus aplicaciones terapeuticas para el tratamiento de enfermedades humanas |
KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
EP2878339A1 (en) | 2013-12-02 | 2015-06-03 | Siena Biotech S.p.A. | SIP3 antagonists |
MX2017002610A (es) | 2014-08-29 | 2017-10-11 | Tes Pharma S R L | INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA. |
WO2016185342A1 (en) | 2015-05-15 | 2016-11-24 | Aurigene Discovery Technologies Limited | Substituted tetrahydroquinolinone compounds as ror gamma modulators |
CA3038185A1 (en) | 2016-10-14 | 2018-04-19 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
JP2021526130A (ja) | 2018-06-12 | 2021-09-30 | ブイティーブイ・セラピューティクス・エルエルシー | インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用 |
MX2021005904A (es) | 2018-11-20 | 2021-09-08 | Tes Pharma S R L | Inhibidores de la ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3840550A (en) * | 1971-05-24 | 1974-10-08 | Ciba Geigy Corp | Certain 6-isothiocyanobenzothiazoles |
US6320050B1 (en) * | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
HUP0200396A3 (en) * | 1999-03-29 | 2003-04-28 | Hoffmann La Roche | Gluckokinase activators, process for their preparation, pharmaceutical compositions containing them and their use |
-
2001
- 2001-11-28 WO PCT/EP2001/013870 patent/WO2002046173A1/en active IP Right Grant
- 2001-11-28 CA CA002429642A patent/CA2429642C/en not_active Expired - Fee Related
- 2001-11-28 DK DK01999565T patent/DK1341774T3/da active
- 2001-11-28 BR BR0115999-2A patent/BR0115999A/pt not_active IP Right Cessation
- 2001-11-28 AU AU2002221902A patent/AU2002221902B2/en not_active Ceased
- 2001-11-28 PT PT01999565T patent/PT1341774E/pt unknown
- 2001-11-28 JP JP2002547912A patent/JP4109111B2/ja not_active Expired - Fee Related
- 2001-11-28 AT AT01999565T patent/ATE316965T1/de not_active IP Right Cessation
- 2001-11-28 ES ES01999565T patent/ES2256340T3/es not_active Expired - Lifetime
- 2001-11-28 CN CNB018194494A patent/CN1226294C/zh not_active Expired - Fee Related
- 2001-11-28 DE DE60117059T patent/DE60117059T2/de not_active Expired - Lifetime
- 2001-11-28 KR KR1020037007517A patent/KR100545431B1/ko not_active IP Right Cessation
- 2001-11-28 AU AU2190202A patent/AU2190202A/xx active Pending
- 2001-11-28 EP EP01999565A patent/EP1341774B1/en not_active Expired - Lifetime
- 2001-12-04 US US10/007,091 patent/US6448399B1/en not_active Expired - Fee Related
- 2001-12-04 AR ARP010105639A patent/AR031627A1/es unknown
- 2001-12-04 PA PA20018534301A patent/PA8534301A1/es unknown
- 2001-12-04 US US10/006,168 patent/US6441184B1/en not_active Expired - Fee Related
- 2001-12-04 US US10/006,170 patent/US6545155B2/en not_active Expired - Fee Related
- 2001-12-04 PE PE2001001217A patent/PE20020753A1/es not_active Application Discontinuation
- 2001-12-05 UY UY27055A patent/UY27055A1/es not_active Application Discontinuation
- 2001-12-05 GT GT200100243A patent/GT200100243A/es unknown
-
2003
- 2003-05-14 ZA ZA200303748A patent/ZA200303748B/en unknown
- 2003-06-06 MX MXPA03005119A patent/MXPA03005119A/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CN1476438A (zh) | 2004-02-18 |
CA2429642A1 (en) | 2002-06-13 |
AU2002221902B2 (en) | 2006-11-23 |
PA8534301A1 (es) | 2002-08-26 |
DE60117059D1 (de) | 2006-04-13 |
BR0115999A (pt) | 2003-09-30 |
US20020103199A1 (en) | 2002-08-01 |
DE60117059T2 (de) | 2006-10-26 |
MXPA03005119A (es) | 2004-10-15 |
US6448399B1 (en) | 2002-09-10 |
EP1341774A1 (en) | 2003-09-10 |
CA2429642C (en) | 2007-11-20 |
WO2002046173A1 (en) | 2002-06-13 |
GT200100243A (es) | 2002-06-04 |
PE20020753A1 (es) | 2002-08-27 |
KR20030068555A (ko) | 2003-08-21 |
US20020107396A1 (en) | 2002-08-08 |
AR031627A1 (es) | 2003-09-24 |
JP4109111B2 (ja) | 2008-07-02 |
ATE316965T1 (de) | 2006-02-15 |
UY27055A1 (es) | 2002-07-31 |
EP1341774B1 (en) | 2006-02-01 |
US6441184B1 (en) | 2002-08-27 |
US20020103241A1 (en) | 2002-08-01 |
KR100545431B1 (ko) | 2006-01-24 |
CN1226294C (zh) | 2005-11-09 |
AU2190202A (en) | 2002-06-18 |
PT1341774E (pt) | 2006-05-31 |
JP2004517087A (ja) | 2004-06-10 |
ZA200303748B (en) | 2004-08-16 |
ES2256340T3 (es) | 2006-07-16 |
US6545155B2 (en) | 2003-04-08 |
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