DE60108108D1 - Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren - Google Patents

Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren

Info

Publication number
DE60108108D1
DE60108108D1 DE60108108T DE60108108T DE60108108D1 DE 60108108 D1 DE60108108 D1 DE 60108108D1 DE 60108108 T DE60108108 T DE 60108108T DE 60108108 T DE60108108 T DE 60108108T DE 60108108 D1 DE60108108 D1 DE 60108108D1
Authority
DE
Germany
Prior art keywords
glucocyase
alkynylphenyl
heteroaromatic
activators
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60108108T
Other languages
English (en)
Other versions
DE60108108T2 (de
Inventor
Paige Erin Mahaney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60108108D1 publication Critical patent/DE60108108D1/de
Application granted granted Critical
Publication of DE60108108T2 publication Critical patent/DE60108108T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60108108T 2000-05-03 2001-04-25 Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren Expired - Lifetime DE60108108T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20154600P 2000-05-03 2000-05-03
US201546P 2000-05-03
PCT/EP2001/004654 WO2001083465A2 (en) 2000-05-03 2001-04-25 Alkynyl phenyl heteroaromatic glucokinase activators

Publications (2)

Publication Number Publication Date
DE60108108D1 true DE60108108D1 (de) 2005-02-03
DE60108108T2 DE60108108T2 (de) 2005-12-08

Family

ID=22746271

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60108108T Expired - Lifetime DE60108108T2 (de) 2000-05-03 2001-04-25 Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren

Country Status (18)

Country Link
US (1) US6388071B2 (de)
EP (1) EP1282612B1 (de)
JP (1) JP3788935B2 (de)
KR (1) KR100502033B1 (de)
CN (1) CN1176915C (de)
AR (1) AR032453A1 (de)
AT (1) ATE286036T1 (de)
AU (2) AU7049401A (de)
BR (1) BR0110573A (de)
CA (1) CA2407416C (de)
DE (1) DE60108108T2 (de)
EC (1) ECSP014054A (de)
ES (1) ES2233660T3 (de)
MX (1) MXPA02010745A (de)
PE (1) PE20011310A1 (de)
PT (1) PT1282612E (de)
WO (1) WO2001083465A2 (de)
ZA (1) ZA200208542B (de)

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EP1336607A1 (de) * 2002-02-19 2003-08-20 Novo Nordisk A/S Amidderivate als Glucokinase-Aktivatoren
US6911545B2 (en) 2001-12-19 2005-06-28 Hoffman-La Roche Inc. Crystals of glucokinase and methods of growing them
GB2409678B (en) * 2001-12-19 2005-09-21 Hoffmann La Roche Crystals of glucokinase and methods of growing them and ligands of glucokinase
WO2003055482A1 (en) 2001-12-21 2003-07-10 Novo Nordisk A/S Amide derivatives as gk activators
RU2340605C2 (ru) 2002-06-27 2008-12-10 Ново Нордиск А/С Арилкарбонильные производные в качестве терапевтических средств
EP1531815B1 (de) 2002-06-27 2014-09-24 Novo Nordisk A/S Glukokinase-aktivatoren
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GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
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US7132425B2 (en) 2002-12-12 2006-11-07 Hoffmann-La Roche Inc. 5-substituted-six-membered heteroaromatic glucokinase activators
WO2004063179A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Substituted arylcyclopropylacetamides as glucokinase activators
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PT1723128E (pt) 2004-01-06 2013-02-27 Novo Nordisk As Heteroaril-ureias e o seu uso como activadores da glicoquinase
EP1718625A1 (de) * 2004-02-18 2006-11-08 AstraZeneca AB Verbindungen
WO2005080359A1 (en) * 2004-02-18 2005-09-01 Astrazeneca Ab Benzamide derivatives and their use as glucokinae activating agents
JP4700684B2 (ja) 2004-04-02 2011-06-15 ノバルティス アーゲー ２型糖尿病の処置に有用なグルコキナーゼアクティベーターとしてのスルホンアミド−チアゾロピリジン誘導体
CA2561157A1 (en) 2004-04-02 2005-10-13 Novartis Ag Thiazolopyridine derivatives, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1802570A1 (de) 2004-10-16 2007-07-04 AstraZeneca AB Verfahren zur herstellung von phenoxybenzamidverbindungen
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1824835A1 (de) 2004-12-03 2007-08-29 Novo Nordisk A/S Heteroaromatische glucokinaseaktivatoren
US20110059941A1 (en) * 2005-05-24 2011-03-10 Peter William Rodney Caulkett 2-phenyl substituted imidazol [4,5b] pyridine/pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
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US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
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WO2007007040A1 (en) * 2005-07-09 2007-01-18 Astrazeneca Ab 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
EP1910317B1 (de) 2005-07-20 2013-07-03 Eli Lilly And Company 1-amino-verbundene verbindungen
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JP5302012B2 (ja) 2006-03-08 2013-10-02 タケダ カリフォルニア インコーポレイテッド グルコキナーゼ活性剤
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EP2046755A2 (de) 2006-07-24 2009-04-15 F. Hoffmann-Roche AG Pyrazole als glucokinase-aktivatoren
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CL2007003061A1 (es) * 2006-10-26 2008-08-01 Astrazeneca Ab Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2.
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Also Published As

Publication number Publication date
ZA200208542B (en) 2004-01-22
MXPA02010745A (es) 2003-03-10
CN1432004A (zh) 2003-07-23
PT1282612E (pt) 2005-04-29
AR032453A1 (es) 2003-11-12
JP3788935B2 (ja) 2006-06-21
KR20020093117A (ko) 2002-12-12
AU2001270494B2 (en) 2005-11-10
JP2003531898A (ja) 2003-10-28
KR100502033B1 (ko) 2005-07-25
PE20011310A1 (es) 2001-12-31
US6388071B2 (en) 2002-05-14
CA2407416C (en) 2006-07-18
ES2233660T3 (es) 2005-06-16
ECSP014054A (es) 2002-01-25
CA2407416A1 (en) 2001-11-08
WO2001083465A3 (en) 2002-05-16
BR0110573A (pt) 2003-04-01
US20010053851A1 (en) 2001-12-20
CN1176915C (zh) 2004-11-24
WO2001083465A2 (en) 2001-11-08
EP1282612A2 (de) 2003-02-12
DE60108108T2 (de) 2005-12-08
AU7049401A (en) 2001-11-12
EP1282612B1 (de) 2004-12-29
ATE286036T1 (de) 2005-01-15

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