PE20011310A1 - Alquinil fenil amidas heteroaromaticas como activadores de la glucokinasa - Google Patents
Alquinil fenil amidas heteroaromaticas como activadores de la glucokinasaInfo
- Publication number
- PE20011310A1 PE20011310A1 PE2001000383A PE2001000383A PE20011310A1 PE 20011310 A1 PE20011310 A1 PE 20011310A1 PE 2001000383 A PE2001000383 A PE 2001000383A PE 2001000383 A PE2001000383 A PE 2001000383A PE 20011310 A1 PE20011310 A1 PE 20011310A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- alkinyl
- glucokinase
- heteroaromaticas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
SE REFIERE A COMPUESTOS ALQUINIL FENIL AMIDAS HETEROAROMATICAS DE FORMULA I DONDE R ES H, ALQUILO, OH-ALQUILO, ALCOXILO-ALQUILO, (R1-)(R2-)N(CH2)n-, CICLOALQUILO C5-C6, ENTRE OTROS; R3 ES CICLOALQUILO C3-C7; R4 ES UN ANILLO HETEROAROMATICO DE 5-6 MIEMBROS, (CH2)mOR6, (CH2)mCOOR7, ENTRE OTROS; n ES 1-2; m ES 0-4; R1, R2, R6, R7, R8 SON H, ALQUILO; R1 Y R2 JUNTO A N FORMAN UN ANILLO HETEROAROMATICO DE 5-6 MIEMBROS. SON COMPUESTOS PREFERIDOS 3-CICLOPENTIL-2-(4-ETINIL-FENIL)-N-TIAZOL-2-IL-PROPIONAMIDA, 3-CICLOPENTIL-2-[4-(3-METOXI-PROP-1-INIL)FENIL]-N-TIAZOL-2IL-PROPIONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES ACTIVADOR DE GLUCOQUINASA AUMENTANDO LA SECRECION DE INSULINA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE DIABETES TIPO II
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20154600P | 2000-05-03 | 2000-05-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20011310A1 true PE20011310A1 (es) | 2001-12-31 |
Family
ID=22746271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000383A PE20011310A1 (es) | 2000-05-03 | 2001-04-27 | Alquinil fenil amidas heteroaromaticas como activadores de la glucokinasa |
Country Status (18)
Country | Link |
---|---|
US (1) | US6388071B2 (es) |
EP (1) | EP1282612B1 (es) |
JP (1) | JP3788935B2 (es) |
KR (1) | KR100502033B1 (es) |
CN (1) | CN1176915C (es) |
AR (1) | AR032453A1 (es) |
AT (1) | ATE286036T1 (es) |
AU (2) | AU7049401A (es) |
BR (1) | BR0110573A (es) |
CA (1) | CA2407416C (es) |
DE (1) | DE60108108T2 (es) |
EC (1) | ECSP014054A (es) |
ES (1) | ES2233660T3 (es) |
MX (1) | MXPA02010745A (es) |
PE (1) | PE20011310A1 (es) |
PT (1) | PT1282612E (es) |
WO (1) | WO2001083465A2 (es) |
ZA (1) | ZA200208542B (es) |
Families Citing this family (73)
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SE0102300D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
EP1336607A1 (en) * | 2002-02-19 | 2003-08-20 | Novo Nordisk A/S | Amide derivatives as glucokinase activators |
US6911545B2 (en) | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
GB2409678B (en) * | 2001-12-19 | 2005-09-21 | Hoffmann La Roche | Crystals of glucokinase and methods of growing them and ligands of glucokinase |
HUP0402309A3 (en) * | 2001-12-21 | 2008-09-29 | Novo Nordisk As | Amide derivatives as glucokinase activators and pharmaceutical compositions containing them |
RU2340605C2 (ru) | 2002-06-27 | 2008-12-10 | Ново Нордиск А/С | Арилкарбонильные производные в качестве терапевтических средств |
PL215132B1 (pl) | 2002-06-27 | 2013-10-31 | Novo Nordisk As | Pochodna arylokarbonylowa jako srodek terapeutyczny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca |
BR0314864A (pt) * | 2002-10-03 | 2005-08-02 | Novartis Ag | Compostos orgânicos |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
US7132425B2 (en) | 2002-12-12 | 2006-11-07 | Hoffmann-La Roche Inc. | 5-substituted-six-membered heteroaromatic glucokinase activators |
DE60336850D1 (en) * | 2003-01-06 | 2011-06-01 | Lilly Co Eli | Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren |
PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
ES2399052T3 (es) | 2004-01-06 | 2013-03-25 | Novo Nordisk A/S | Heteroaril-ureas y su uso como activadores de glucocinasa |
BRPI0507734A (pt) * | 2004-02-18 | 2007-07-10 | Astrazeneca Ab | composto ou um sal, pró-droga ou solvato do mesmo, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto |
ES2322709T3 (es) * | 2004-02-18 | 2009-06-25 | Astrazeneca Ab | Derivados de benzamida y su uso como agentes activadores de la glucocinasa. |
BRPI0509573A (pt) | 2004-04-02 | 2007-09-25 | Novartis Ag | derivados de sulfonamida-tiazolpiridina como ativadores de glicocinase úteis para o tratamento de diabetes do tipo 2 |
MXPA06011365A (es) | 2004-04-02 | 2006-12-15 | Novartis Ag | Derivados de tiazolo-piridina, composiciones farmaceuticas que los contienen, y metodos para el tratamiento de condiciones mediadas por glucoquinasa. |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
BRPI0516595A (pt) | 2004-10-16 | 2008-09-23 | Astrazeneca Ab | processo para fabricar um composto, e, composto |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
MX2007006420A (es) * | 2004-12-03 | 2007-07-19 | Novo Nordisk As | Activadores heteroaromaticos de glucocinasa. |
JP2008542247A (ja) * | 2005-05-24 | 2008-11-27 | アストラゼネカ アクチボラグ | グルコキナーゼモジュレーターとしての2−フェニル置換イミダゾール[4,5b]ピリジン/ピラジンおよびプリン誘導体 |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
WO2007006760A1 (en) | 2005-07-08 | 2007-01-18 | Novo Nordisk A/S | Dicycloalkyl urea glucokinase activators |
EP2027113A1 (en) * | 2005-07-09 | 2009-02-25 | AstraZeneca AB | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
US7642259B2 (en) * | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
EP1910350A1 (en) * | 2005-07-09 | 2008-04-16 | AstraZeneca AB | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
WO2007015805A1 (en) | 2005-07-20 | 2007-02-08 | Eli Lilly And Company | 1-amino linked compounds |
US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
US20090281142A1 (en) | 2005-08-31 | 2009-11-12 | Astellas Pharma Inc. | Thiazole derivative |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
WO2007039177A2 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
EP1948644A1 (en) * | 2005-11-03 | 2008-07-30 | Prosidion Limited | Tricyclo substituted amides |
PT1951658E (pt) | 2005-11-17 | 2012-11-12 | Lilly Co Eli | Antagonistas do receptor do glucagon, preparação e utilizações terapêuticas |
JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
US8034822B2 (en) | 2006-03-08 | 2011-10-11 | Takeda San Diego, Inc. | Glucokinase activators |
US8211925B2 (en) | 2006-04-28 | 2012-07-03 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
EP2049518B1 (en) | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents. |
BRPI0715531A2 (pt) | 2006-07-24 | 2014-06-24 | Hoffmann La Roche | Composto, composição farmacêutica, método para o tratamento de uma enfermidade e/ou distúrbio metabólico, processo para a preparação de compostos e uso do composto |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
TW200825060A (en) * | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
WO2008079787A2 (en) | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
CA2671535A1 (en) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Novel crystalline compound useful as glk activator |
TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
CN101622231B (zh) | 2007-02-28 | 2013-12-04 | 艾德维纳斯医疗私人有限公司 | 作为葡糖激酶激活剂的2,2,2-三取代的乙酰胺衍生物、它们的制造方法和药学应用 |
TW200902489A (en) * | 2007-03-07 | 2009-01-16 | Kyorin Seiyaku Kk | Glucokinase-activating substance |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
CL2009000004A1 (es) * | 2008-01-15 | 2010-02-19 | Lilly Co Eli | Forma cristalina de r-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida; composicion farmaceutica que comprende a dicha forma cristalina; y uso para el tratamiento de diabetes o hiperglicemia. |
CN101918363B (zh) | 2008-01-18 | 2012-09-05 | 安斯泰来制药株式会社 | 苯乙酰胺衍生物 |
US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
AU2009241137B2 (en) | 2008-04-28 | 2013-10-03 | Kyorin Pharmaceutical Co., Ltd. | Cyclopentylacrylic acid amide derivative |
KR20110052676A (ko) | 2008-08-04 | 2011-05-18 | 아스트라제네카 아베 | 피라졸로[3,4]피리미딘-4-일 유도체 및 당뇨병 및 비만을 치료하기 위한 이의 용도 |
UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
AR076220A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivados de pirazol [4,5 - e] pirimidina |
US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
ES2624780T3 (es) | 2010-03-31 | 2017-07-17 | The Scripps Research Institute | Reprogramación de células |
US8877754B2 (en) * | 2010-09-06 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
WO2014035872A1 (en) * | 2012-08-27 | 2014-03-06 | Amgen Inc. | Tricyclic alkynes that interact with glucokinase regulatory protein |
EP2878339A1 (en) | 2013-12-02 | 2015-06-03 | Siena Biotech S.p.A. | SIP3 antagonists |
EP3053834B1 (en) | 2015-02-04 | 2019-03-27 | Tetra Laval Holdings & Finance S.A. | Forming assembly and method for forming a plurality of sealed packs for pourable food products starting from a tube of packaging material |
EP3806852A1 (en) | 2018-06-12 | 2021-04-21 | vTv Therapeutics LLC | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61115054A (ja) * | 1984-11-08 | 1986-06-02 | Taisho Pharmaceut Co Ltd | スチレンアルカン酸誘導体 |
AU6110496A (en) * | 1995-06-07 | 1996-12-30 | Sugen, Inc. | Phosphatase inhibitors |
DK0994108T3 (da) * | 1997-06-24 | 2003-08-18 | Zeria Pharm Co Ltd | Fremgangsmåde til fremstilling af 2-hydroxybenzamidderivater |
-
2001
- 2001-04-25 CA CA002407416A patent/CA2407416C/en not_active Expired - Fee Related
- 2001-04-25 JP JP2001580894A patent/JP3788935B2/ja not_active Expired - Fee Related
- 2001-04-25 WO PCT/EP2001/004654 patent/WO2001083465A2/en active IP Right Grant
- 2001-04-25 DE DE60108108T patent/DE60108108T2/de not_active Expired - Lifetime
- 2001-04-25 US US09/841,983 patent/US6388071B2/en not_active Expired - Fee Related
- 2001-04-25 KR KR10-2002-7014725A patent/KR100502033B1/ko not_active IP Right Cessation
- 2001-04-25 AU AU7049401A patent/AU7049401A/xx active Pending
- 2001-04-25 EP EP01949294A patent/EP1282612B1/en not_active Expired - Lifetime
- 2001-04-25 BR BR0110573-6A patent/BR0110573A/pt not_active IP Right Cessation
- 2001-04-25 PT PT01949294T patent/PT1282612E/pt unknown
- 2001-04-25 ES ES01949294T patent/ES2233660T3/es not_active Expired - Lifetime
- 2001-04-25 AU AU2001270494A patent/AU2001270494B2/en not_active Ceased
- 2001-04-25 CN CNB018089127A patent/CN1176915C/zh not_active Expired - Fee Related
- 2001-04-25 MX MXPA02010745A patent/MXPA02010745A/es active IP Right Grant
- 2001-04-25 AT AT01949294T patent/ATE286036T1/de not_active IP Right Cessation
- 2001-04-27 PE PE2001000383A patent/PE20011310A1/es not_active Application Discontinuation
- 2001-04-30 AR ARP010102035A patent/AR032453A1/es not_active Application Discontinuation
- 2001-05-03 EC EC2001004054A patent/ECSP014054A/es unknown
-
2002
- 2002-10-22 ZA ZA200208542A patent/ZA200208542B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE60108108D1 (de) | 2005-02-03 |
US6388071B2 (en) | 2002-05-14 |
AU7049401A (en) | 2001-11-12 |
CA2407416A1 (en) | 2001-11-08 |
JP2003531898A (ja) | 2003-10-28 |
MXPA02010745A (es) | 2003-03-10 |
CA2407416C (en) | 2006-07-18 |
JP3788935B2 (ja) | 2006-06-21 |
AR032453A1 (es) | 2003-11-12 |
BR0110573A (pt) | 2003-04-01 |
AU2001270494B2 (en) | 2005-11-10 |
CN1176915C (zh) | 2004-11-24 |
KR100502033B1 (ko) | 2005-07-25 |
EP1282612B1 (en) | 2004-12-29 |
ES2233660T3 (es) | 2005-06-16 |
WO2001083465A3 (en) | 2002-05-16 |
EP1282612A2 (en) | 2003-02-12 |
DE60108108T2 (de) | 2005-12-08 |
KR20020093117A (ko) | 2002-12-12 |
US20010053851A1 (en) | 2001-12-20 |
PT1282612E (pt) | 2005-04-29 |
WO2001083465A2 (en) | 2001-11-08 |
ZA200208542B (en) | 2004-01-22 |
CN1432004A (zh) | 2003-07-23 |
ECSP014054A (es) | 2002-01-25 |
ATE286036T1 (de) | 2005-01-15 |
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