PE20080345A1 - Derivados de piperazina como agonistas del receptor de gpr38 - Google Patents
Derivados de piperazina como agonistas del receptor de gpr38Info
- Publication number
- PE20080345A1 PE20080345A1 PE2007000819A PE2007000819A PE20080345A1 PE 20080345 A1 PE20080345 A1 PE 20080345A1 PE 2007000819 A PE2007000819 A PE 2007000819A PE 2007000819 A PE2007000819 A PE 2007000819A PE 20080345 A1 PE20080345 A1 PE 20080345A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- phenyl
- alkyl
- piperazinyl
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I; DONDE A ES FENILO O UN ANILLO HETEROARILO DE 6 MIEMBROS OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4; B ES FENILO OPCIONALMENTE SUSTITUIDO, UN ANILLO HETEROARILO DE 6 MIEMBROS QUE PUEDE CONECTARSE AL CARBONO DE LA AMIDA; Y ES NH, N-ALQUILO C1-C4, O, C=O, CH2; R1 Y R2 SON CADA UNO H, ALQUILO C1-C4; R3 ES FENILO SUSTITUIDO O NO, HETEROARILO, HETEROCICLICO; R4 ES H, ALQUILO C1-C4, ALCOXIALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: 6-(3-FLUOROFENIL)-N-METIL-N-(4-{[(3S)-3-METIL-1-PIPERAZINIL]METIL}FENIL)-3-PIRIDINACARBOXAMIDA, 4'-FLUORO-N-METIL-N-(4-{[(3S)-3-METIL-1-PIPERAZINIL]METIL}FENIL)-4-BIFENILCARBOXAMIDA, N-{4-{[(3R,5S)-3,5-DIMETIL-1-PIPERAZINIL]METIL} FENIL}-6-(4-FLUOROFENIL)-N,2-DIMETIL-3-PIRIDINACARBOXAMIDA, ENTRE OTROS. REFERIDA TAMBIEN A COMPOSICIONES FARMACEUTICAS. DICHOS COMPUESTOS SON AGONISTAS DE GPR38 UTILES EN EL TRATAMIENTO DE REFLUJO GASTROESOFAGICO, DISPEPSIA FUNCIONAL, ESTRENIMIENTO, ILEO PARALITICO, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0612844A GB0612844D0 (en) | 2006-06-28 | 2006-06-28 | Compounds |
GB0711525A GB0711525D0 (en) | 2007-06-14 | 2007-06-14 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080345A1 true PE20080345A1 (es) | 2008-05-29 |
Family
ID=38476358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000819A PE20080345A1 (es) | 2006-06-28 | 2007-06-26 | Derivados de piperazina como agonistas del receptor de gpr38 |
Country Status (30)
Country | Link |
---|---|
US (2) | US7700599B2 (es) |
EP (1) | EP2041093B1 (es) |
JP (1) | JP5028484B2 (es) |
KR (1) | KR20090031688A (es) |
AR (1) | AR061656A1 (es) |
AT (1) | ATE465150T1 (es) |
AU (1) | AU2007263712B2 (es) |
BR (1) | BRPI0713443A2 (es) |
CA (1) | CA2655540A1 (es) |
CR (1) | CR10497A (es) |
CY (1) | CY1110190T1 (es) |
DE (1) | DE602007006019D1 (es) |
DK (1) | DK2041093T3 (es) |
EA (1) | EA015820B1 (es) |
ES (1) | ES2344484T3 (es) |
HK (1) | HK1127608A1 (es) |
HR (1) | HRP20100284T1 (es) |
IL (1) | IL195900A0 (es) |
JO (1) | JO2645B1 (es) |
MA (1) | MA30539B1 (es) |
MX (1) | MX2009000110A (es) |
MY (1) | MY147677A (es) |
NO (1) | NO20090266L (es) |
NZ (1) | NZ573450A (es) |
PE (1) | PE20080345A1 (es) |
PL (1) | PL2041093T3 (es) |
PT (1) | PT2041093E (es) |
SI (1) | SI2041093T1 (es) |
TW (1) | TWI391386B (es) |
WO (1) | WO2008000729A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0611907D0 (en) | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
CA2616513C (en) | 2005-07-26 | 2013-02-19 | Glaxo Group Limited | Benzylpiperazine derivates useful for the treatment of gastrointestinal disorders |
GB0524814D0 (en) * | 2005-12-05 | 2006-01-11 | Glaxo Group Ltd | Compounds |
JP5028484B2 (ja) * | 2006-06-28 | 2012-09-19 | グラクソ グループ リミテッド | Gpr38受容体媒介疾患の治療に有用なピペラジニル誘導体 |
GB0723317D0 (en) * | 2007-11-28 | 2008-01-09 | Glaxo Group Ltd | Compounds |
RU2533116C2 (ru) * | 2009-02-27 | 2014-11-20 | Раквалиа Фарма Инк. | Оксииндольные производные, обладающие агонистической активностью в отношении мотилинового рецептора |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
AR080055A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1 |
AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
IN2013MN00506A (es) * | 2010-09-27 | 2015-05-29 | Daiichi Sankyo Companyltd | |
US9321727B2 (en) | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
RS60825B1 (sr) | 2016-03-17 | 2020-10-30 | Hoffmann La Roche | Aktivnost derivata 5-etiol-4-metil-pirazol-3-karboksamida kao agonista taar-a |
WO2022063197A1 (zh) * | 2020-09-25 | 2022-03-31 | 上海美悦生物科技发展有限公司 | 一种嘧啶甲酰胺类化合物及其应用 |
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US5385912A (en) | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
TW355711B (en) | 1992-11-04 | 1999-04-11 | Chugai Pharmaceutical Co Ltd | Erythromycin derivatives |
JPH06211886A (ja) | 1992-11-04 | 1994-08-02 | Chugai Pharmaceut Co Ltd | エリスロマイシン誘導体 |
US5593994A (en) | 1994-09-29 | 1997-01-14 | The Dupont Merck Pharmaceutical Company | Prostaglandin synthase inhibitors |
JP3901239B2 (ja) | 1996-03-13 | 2007-04-04 | 大正製薬株式会社 | アリールアルカン誘導体 |
US5965578A (en) | 1996-04-03 | 1999-10-12 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
DE19644195A1 (de) | 1996-10-24 | 1998-04-30 | Solvay Pharm Gmbh | 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
WO1998023629A1 (fr) | 1996-11-26 | 1998-06-04 | Chugai Seiyaku Kabushiki Kaisha | Composes de macrolides comportant une chaine a 13 elements, medicament les contenant et leur procede de preparation |
US6060491A (en) | 1997-06-19 | 2000-05-09 | Dupont Pharmaceuticals | 6-membered aromatics as factor Xa inhibitors |
US5972939A (en) | 1997-10-28 | 1999-10-26 | Ortho-Mcneil Pharmaceutical, Inc. | Cyclopentene derivatives useful as antagonists of the motilin receptor |
DE19805822B4 (de) | 1998-02-13 | 2009-02-05 | Solvay Pharmaceuticals Gmbh | 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US6165985A (en) * | 1998-02-13 | 2000-12-26 | Solvay Pharmaceuticals Gmbh | 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them |
GB9804734D0 (en) | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
EP2308833A3 (en) * | 1999-04-15 | 2011-09-28 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
US20020010184A1 (en) | 2000-02-18 | 2002-01-24 | Dinsmore Christopher J. | Inhibitors of prenyl-protein transferase |
US20020052380A1 (en) | 2000-02-18 | 2002-05-02 | Dinsmore Christopher J. | Inhibitors of prenyl-protein transferase |
US6423714B2 (en) | 2000-03-13 | 2002-07-23 | Ortho Mcneil-Pharmaceutical, Inc.. | Cyclohexene derivatives useful as antagonists of the motilin receptor |
AU2001247357A1 (en) | 2000-03-13 | 2001-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | Novel cyclobutene derivatives useful as antagonists of the motilin receptor |
AU2001249144A1 (en) | 2000-03-13 | 2001-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | Novel cyclopentene derivatives useful as antagonists of the motilin receptor |
US6511980B2 (en) * | 2000-05-05 | 2003-01-28 | Ortho Mcneil Pharmaceutical, Inc. | Substituted diamine derivatives useful as motilin antagonists |
GB0013378D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Use of therapeutic benzamide derivatives |
US7102009B2 (en) * | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7105682B2 (en) * | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
JP2004529184A (ja) * | 2001-05-10 | 2004-09-24 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規1−アミドメチルカルボニル−ピペリジン誘導体、該誘導体を製造するための方法及び中間体並びにこれらの化合物を含有している医薬 |
US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
GB0129013D0 (en) * | 2001-12-04 | 2002-01-23 | Glaxo Group Ltd | Compounds |
GB0129015D0 (en) * | 2001-12-04 | 2002-01-23 | Glaxo Group Ltd | Compounds |
SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
US7262195B2 (en) | 2003-09-17 | 2007-08-28 | Bristol-Myers Squibb Company | Compounds useful as motilin agonists and method |
US7338954B2 (en) * | 2003-09-17 | 2008-03-04 | Bristol-Myers Squibb Company | Compounds useful as motilin agonists and method |
KR20060060047A (ko) * | 2003-10-01 | 2006-06-02 | 더 프록터 앤드 갬블 캄파니 | 멜라닌 농축 호르몬 길항제 |
WO2005063720A1 (ja) * | 2003-12-25 | 2005-07-14 | Nippon Shinyaku Co., Ltd. | アミド誘導体及び医薬 |
WO2005077368A2 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
WO2005077345A1 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
WO2005077373A2 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
US20070293539A1 (en) | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
WO2005089502A2 (en) | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
SE0401345D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
GB0611907D0 (en) | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
EP1902022A1 (en) | 2005-07-12 | 2008-03-26 | Glaxo Group Limited | Piperazine heteroaryl derivates as gpr38 agonists |
CA2616513C (en) * | 2005-07-26 | 2013-02-19 | Glaxo Group Limited | Benzylpiperazine derivates useful for the treatment of gastrointestinal disorders |
JP5028484B2 (ja) * | 2006-06-28 | 2012-09-19 | グラクソ グループ リミテッド | Gpr38受容体媒介疾患の治療に有用なピペラジニル誘導体 |
-
2007
- 2007-06-26 JP JP2009517160A patent/JP5028484B2/ja not_active Expired - Fee Related
- 2007-06-26 TW TW096122969A patent/TWI391386B/zh not_active IP Right Cessation
- 2007-06-26 CA CA002655540A patent/CA2655540A1/en not_active Abandoned
- 2007-06-26 BR BRPI0713443-6A patent/BRPI0713443A2/pt not_active IP Right Cessation
- 2007-06-26 PT PT07765616T patent/PT2041093E/pt unknown
- 2007-06-26 DE DE602007006019T patent/DE602007006019D1/de active Active
- 2007-06-26 AU AU2007263712A patent/AU2007263712B2/en not_active Ceased
- 2007-06-26 AT AT07765616T patent/ATE465150T1/de active
- 2007-06-26 MX MX2009000110A patent/MX2009000110A/es active IP Right Grant
- 2007-06-26 EA EA200970065A patent/EA015820B1/ru not_active IP Right Cessation
- 2007-06-26 JO JO2007261A patent/JO2645B1/en active
- 2007-06-26 PL PL07765616T patent/PL2041093T3/pl unknown
- 2007-06-26 PE PE2007000819A patent/PE20080345A1/es not_active Application Discontinuation
- 2007-06-26 DK DK07765616.3T patent/DK2041093T3/da active
- 2007-06-26 SI SI200730257T patent/SI2041093T1/sl unknown
- 2007-06-26 EP EP07765616A patent/EP2041093B1/en active Active
- 2007-06-26 KR KR1020087031612A patent/KR20090031688A/ko not_active Application Discontinuation
- 2007-06-26 US US11/768,339 patent/US7700599B2/en not_active Expired - Fee Related
- 2007-06-26 NZ NZ573450A patent/NZ573450A/en not_active IP Right Cessation
- 2007-06-26 WO PCT/EP2007/056342 patent/WO2008000729A1/en active Application Filing
- 2007-06-26 AR ARP070102835A patent/AR061656A1/es not_active Application Discontinuation
- 2007-06-26 ES ES07765616T patent/ES2344484T3/es active Active
-
2008
- 2008-12-11 CR CR10497A patent/CR10497A/es not_active Application Discontinuation
- 2008-12-11 IL IL195900A patent/IL195900A0/en unknown
- 2008-12-24 MY MYPI20085319A patent/MY147677A/en unknown
- 2008-12-30 MA MA31526A patent/MA30539B1/fr unknown
-
2009
- 2009-01-16 NO NO20090266A patent/NO20090266L/no not_active Application Discontinuation
- 2009-04-02 US US12/417,176 patent/US8853218B2/en not_active Expired - Fee Related
- 2009-07-22 HK HK09106727.8A patent/HK1127608A1/xx unknown
-
2010
- 2010-05-21 HR HR20100284T patent/HRP20100284T1/hr unknown
- 2010-06-11 CY CY20101100521T patent/CY1110190T1/el unknown
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