PE20050090A1 - Indol-3-carboxamidas como activadores de glocoquinasa - Google Patents
Indol-3-carboxamidas como activadores de glocoquinasaInfo
- Publication number
- PE20050090A1 PE20050090A1 PE2003000988A PE2003000988A PE20050090A1 PE 20050090 A1 PE20050090 A1 PE 20050090A1 PE 2003000988 A PE2003000988 A PE 2003000988A PE 2003000988 A PE2003000988 A PE 2003000988A PE 20050090 A1 PE20050090 A1 PE 20050090A1
- Authority
- PE
- Peru
- Prior art keywords
- indol
- chloro
- isopropyl
- activators
- glocokinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I DONDE R1 ES HALOGENO, NITRO, AMINO, ENTRE OTROS; R2 ES ALQUILO INFERIOR C2-C4 O -CH2-R4, DONDE R4 ES CICLOALQUILO C3-C6; R3 ES ANILLO HETEROAROMATICO DE 5 A 6 MIEMBROS MONO O NO SUSTITUIDO. TAMBIEN REFERIDA A LA PREPARACION DE ESTE COMPUESTO. SON PREFERIDOS: TIAZOL-2-ILAMIDA DEL ACIDO 1-ISOPROPIL-6-METIL-1H-INDOL-3-CARBOXILICO; [1,3,4]TIADIAZOL-2-ILAMIDA DEL ACIDO 6-CLORO-1-ISOPROPIL-1H-INDOL-3-CARBOXILICO Y (5-CLORO-PIRIDIN-2-IL)-AMIDA DEL ACIDO 6-CLORO-1-ISOPROPIL-1H-INDOL-3-CARBOXILICO; ENTRE OTROS. DICHOS COMPUESTOS SON ACTIVADORES DE LA GLUCOQUINASA UTILES EN EL INCREMENTO DE SECRECION DE INSULINA EN EL TRATAMIENTO DE DIABETES DE TIPO II
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41573702P | 2002-10-03 | 2002-10-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050090A1 true PE20050090A1 (es) | 2005-02-28 |
Family
ID=32069904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000988A PE20050090A1 (es) | 2002-10-03 | 2003-09-30 | Indol-3-carboxamidas como activadores de glocoquinasa |
Country Status (29)
Country | Link |
---|---|
US (1) | US6881844B2 (es) |
EP (1) | EP1549638B1 (es) |
JP (1) | JP4390704B2 (es) |
KR (1) | KR100646486B1 (es) |
CN (1) | CN100348596C (es) |
AR (1) | AR041467A1 (es) |
AT (1) | ATE374768T1 (es) |
AU (1) | AU2003270285B2 (es) |
BR (1) | BR0315047A (es) |
CA (1) | CA2499329C (es) |
DE (1) | DE60316709T2 (es) |
DK (1) | DK1549638T3 (es) |
ES (1) | ES2293005T3 (es) |
HK (1) | HK1083098A1 (es) |
HR (1) | HRP20050287A2 (es) |
MX (1) | MXPA05003391A (es) |
MY (1) | MY136764A (es) |
NO (1) | NO20051103L (es) |
NZ (1) | NZ538466A (es) |
PA (1) | PA8584001A1 (es) |
PE (1) | PE20050090A1 (es) |
PL (1) | PL375149A1 (es) |
PT (1) | PT1549638E (es) |
RU (1) | RU2309956C2 (es) |
SI (1) | SI1549638T1 (es) |
TW (1) | TW200413364A (es) |
UY (1) | UY28005A1 (es) |
WO (1) | WO2004031179A1 (es) |
ZA (1) | ZA200502619B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
KR20050074959A (ko) * | 2002-10-03 | 2005-07-19 | 노파르티스 아게 | 제ii형 당뇨병 치료에 유용한 글루코키나아제 활성인자로서의 치환된 (티아졸-2-일)-아미드 또는 술폰아미드 |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
GB0226930D0 (en) * | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
EP1737870A1 (en) | 2004-04-02 | 2007-01-03 | Novartis AG | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
AU2005229416B2 (en) | 2004-04-02 | 2009-03-26 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of type 2 diabetes |
US8957070B2 (en) | 2005-04-20 | 2015-02-17 | Takeda Pharmaceutical Company Limited | Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity |
US7622492B2 (en) | 2005-08-31 | 2009-11-24 | Hoffmann-La Roche Inc. | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
CN101272784A (zh) | 2005-09-29 | 2008-09-24 | 塞诺菲-安万特股份有限公司 | 苯基-和吡啶基-1,2,4-噁二唑酮衍生物、它们的制备方法和它们作为药物的用途 |
GT200600429A (es) * | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
US7799820B2 (en) | 2005-09-30 | 2010-09-21 | Banyu Pharmaceutical Co., Ltd. | 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions |
GT200600428A (es) * | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
JP2009013065A (ja) * | 2005-10-14 | 2009-01-22 | Astellas Pharma Inc | 縮合へテロ環化合物 |
JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
US7351706B2 (en) * | 2006-01-05 | 2008-04-01 | Hoffmann-La Roche Inc. | Indol-3-yl-carbonyl-spiro-piperidine derivatives |
JP5302012B2 (ja) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
EP1849785A1 (en) | 2006-04-28 | 2007-10-31 | Neuropharma, S.A. | N-(2-Thiazolyl)-amide derivatives as GSK-3 inhibitors |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP2049518B1 (en) | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents. |
US7652133B2 (en) | 2006-10-19 | 2010-01-26 | Takeda Pharmaceutical Company Limited | Indole compound |
WO2008074694A1 (en) * | 2006-12-20 | 2008-06-26 | F. Hoffmann-La Roche Ag | Crystallization of glucokinase activators |
EP2091947A2 (en) | 2006-12-20 | 2009-08-26 | Takeda San Diego, Inc. | Glucokinase activators |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
AU2008286946B2 (en) * | 2007-08-10 | 2013-11-21 | H. Lundbeck A/S | Heteroaryl amide analogues |
PE20141375A1 (es) | 2008-05-16 | 2014-10-23 | Takeda San Diego Inc | Activadores de glucoquinasa |
AU2010226857B2 (en) | 2009-03-20 | 2016-07-14 | University Of Virginia Patent Foundation | Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials |
JP2011006366A (ja) | 2009-06-26 | 2011-01-13 | Sanwa Kagaku Kenkyusho Co Ltd | 新規チオフェンカルボキサミド誘導体及びその医薬用途 |
US9333193B2 (en) | 2010-09-20 | 2016-05-10 | University Of Virginia Patent Foundation | Compositions and methods for treating tuberculosis |
CN103044310B (zh) * | 2013-01-18 | 2015-02-04 | 贵阳医学院 | 二氢吲哚-3-乙酸衍生物、其制备方法以及在药物中的应用 |
WO2023067628A1 (en) * | 2021-10-20 | 2023-04-27 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) | A method for the preparation of indole-3-carboxylic acid derivatives |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2740686B1 (fr) | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
US6262096B1 (en) | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
JP5278983B2 (ja) | 1999-11-17 | 2013-09-04 | 塩野義製薬株式会社 | アミド化合物の新規用途 |
BR0115999A (pt) | 2000-12-06 | 2003-09-30 | Hoffmann La Roche | Composto, composição farmacêutica que compreende o mesmo, sua utilização, processo para o tratamento profilático ou terapêutico de diabetes do tipo ii e processo para a preparação do composto |
US6433188B1 (en) | 2000-12-06 | 2002-08-13 | Wendy Lea Corbett | Fused heteroaromatic glucokinase activators |
US6482951B2 (en) | 2000-12-13 | 2002-11-19 | Hoffmann-La Roche Inc. | Isoindolin-1-one glucokinase activators |
US7157487B2 (en) * | 2000-12-28 | 2007-01-02 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
UA77303C2 (en) * | 2002-06-14 | 2006-11-15 | Pfizer | Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use |
-
2003
- 2003-09-26 ES ES03750648T patent/ES2293005T3/es not_active Expired - Lifetime
- 2003-09-26 JP JP2004540731A patent/JP4390704B2/ja not_active Expired - Fee Related
- 2003-09-26 DE DE60316709T patent/DE60316709T2/de not_active Expired - Lifetime
- 2003-09-26 WO PCT/EP2003/010776 patent/WO2004031179A1/en active IP Right Grant
- 2003-09-26 PL PL03375149A patent/PL375149A1/xx not_active Application Discontinuation
- 2003-09-26 PT PT03750648T patent/PT1549638E/pt unknown
- 2003-09-26 NZ NZ538466A patent/NZ538466A/en unknown
- 2003-09-26 MX MXPA05003391A patent/MXPA05003391A/es active IP Right Grant
- 2003-09-26 CA CA002499329A patent/CA2499329C/en not_active Expired - Fee Related
- 2003-09-26 KR KR1020057005669A patent/KR100646486B1/ko not_active IP Right Cessation
- 2003-09-26 SI SI200331008T patent/SI1549638T1/sl unknown
- 2003-09-26 RU RU2005113719/04A patent/RU2309956C2/ru not_active IP Right Cessation
- 2003-09-26 AT AT03750648T patent/ATE374768T1/de not_active IP Right Cessation
- 2003-09-26 AU AU2003270285A patent/AU2003270285B2/en not_active Ceased
- 2003-09-26 DK DK03750648T patent/DK1549638T3/da active
- 2003-09-26 BR BR0315047-0A patent/BR0315047A/pt not_active IP Right Cessation
- 2003-09-26 EP EP03750648A patent/EP1549638B1/en not_active Expired - Lifetime
- 2003-09-26 CN CNB038236796A patent/CN100348596C/zh not_active Expired - Fee Related
- 2003-09-30 PA PA20038584001A patent/PA8584001A1/es unknown
- 2003-09-30 PE PE2003000988A patent/PE20050090A1/es not_active Application Discontinuation
- 2003-09-30 US US10/674,481 patent/US6881844B2/en not_active Expired - Fee Related
- 2003-09-30 TW TW092127030A patent/TW200413364A/zh unknown
- 2003-10-01 AR ARP030103589A patent/AR041467A1/es unknown
- 2003-10-01 MY MYPI20033742A patent/MY136764A/en unknown
- 2003-10-01 UY UY28005A patent/UY28005A1/es not_active Application Discontinuation
-
2005
- 2005-03-01 NO NO20051103A patent/NO20051103L/no not_active Application Discontinuation
- 2005-03-24 HR HR20050287A patent/HRP20050287A2/xx not_active Application Discontinuation
-
2006
- 2006-01-19 ZA ZA200502619A patent/ZA200502619B/en unknown
- 2006-04-10 HK HK06104334A patent/HK1083098A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
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