PA8525201A1 - Tetrazolil-fenil acetamidas como activadores de la glucoquinasa - Google Patents

Tetrazolil-fenil acetamidas como activadores de la glucoquinasa

Info

Publication number
PA8525201A1
PA8525201A1 PA20018525201A PA8525201A PA8525201A1 PA 8525201 A1 PA8525201 A1 PA 8525201A1 PA 20018525201 A PA20018525201 A PA 20018525201A PA 8525201 A PA8525201 A PA 8525201A PA 8525201 A1 PA8525201 A1 PA 8525201A1
Authority
PA
Panama
Prior art keywords
tetrazolil
activators
glucoquinase
acetamidas
fenil
Prior art date
Application number
PA20018525201A
Other languages
English (en)
Inventor
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8525201A1 publication Critical patent/PA8525201A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

LAS TETRAZOLIL-FENIL ACETAMIDAS SON ACTIVAS COMO ACTIVADORES DE LA GLUCOQUICASA, Y SON CAPACES DE AUMENTAR LA SECRECION DE LA INSULINA, LO CUAL LAS CONVIERTE EN UTILES PARA EL TRATAMIENTO DE LA DIABETES TIPO II.
PA20018525201A 2000-08-15 2001-08-14 Tetrazolil-fenil acetamidas como activadores de la glucoquinasa PA8525201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22549400P 2000-08-15 2000-08-15

Publications (1)

Publication Number Publication Date
PA8525201A1 true PA8525201A1 (es) 2002-07-30

Family

ID=22845106

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018525201A PA8525201A1 (es) 2000-08-15 2001-08-14 Tetrazolil-fenil acetamidas como activadores de la glucoquinasa

Country Status (20)

Country Link
US (3) US6369232B1 (es)
EP (1) EP1311504B1 (es)
JP (1) JP3961948B2 (es)
KR (1) KR100518061B1 (es)
CN (1) CN1209362C (es)
AR (1) AR031718A1 (es)
AT (1) ATE297921T1 (es)
AU (2) AU8399801A (es)
BR (1) BR0113312A (es)
CA (1) CA2419416C (es)
DE (1) DE60111540T2 (es)
DK (1) DK1311504T3 (es)
ES (1) ES2243541T3 (es)
MX (1) MXPA03001275A (es)
PA (1) PA8525201A1 (es)
PE (1) PE20020386A1 (es)
PT (1) PT1311504E (es)
UY (1) UY26885A1 (es)
WO (1) WO2002014312A1 (es)
ZA (1) ZA200300904B (es)

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* Cited by examiner, † Cited by third party
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SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7087631B2 (en) * 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
US7078423B2 (en) * 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
BR0314864A (pt) * 2002-10-03 2005-08-02 Novartis Ag Compostos orgânicos
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
US7132425B2 (en) 2002-12-12 2006-11-07 Hoffmann-La Roche Inc. 5-substituted-six-membered heteroaromatic glucokinase activators
AU2003294376A1 (en) * 2003-01-06 2004-08-10 Eli Lilly And Company Heteroaryl compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
WO2004072066A1 (en) * 2003-02-11 2004-08-26 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
BRPI0509573A (pt) * 2004-04-02 2007-09-25 Novartis Ag derivados de sulfonamida-tiazolpiridina como ativadores de glicocinase úteis para o tratamento de diabetes do tipo 2
MXPA06011365A (es) * 2004-04-02 2006-12-15 Novartis Ag Derivados de tiazolo-piridina, composiciones farmaceuticas que los contienen, y metodos para el tratamiento de condiciones mediadas por glucoquinasa.
CN101218237B (zh) * 2005-07-11 2012-03-28 田边三菱制药株式会社 肟衍生物及其制备方法
US20090281142A1 (en) 2005-08-31 2009-11-12 Astellas Pharma Inc. Thiazole derivative
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
WO2007039177A2 (en) 2005-09-29 2007-04-12 Sanofi-Aventis Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
EP1948644A1 (en) * 2005-11-03 2008-07-30 Prosidion Limited Tricyclo substituted amides
JP2009515997A (ja) * 2005-11-18 2009-04-16 タケダ サン ディエゴ インコーポレイテッド グルコキナーゼ活性剤
EP1961746B1 (en) * 2005-12-15 2012-03-28 Nihon Nohyaku Co., Ltd. Phthalamide derivative, agricultural or horticultural pesticide, and use of the pesticide
US8034822B2 (en) 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2049518B1 (en) 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.
US7910747B2 (en) * 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
US7902248B2 (en) 2006-12-14 2011-03-08 Hoffmann-La Roche Inc. Oxime glucokinase activators
WO2008079787A2 (en) 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
US8314247B2 (en) * 2007-01-10 2012-11-20 Mitsubishi Tanabe Pharma Corporation Hydrazone derivative
TW200902489A (en) * 2007-03-07 2009-01-16 Kyorin Seiyaku Kk Glucokinase-activating substance
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
WO2009047798A2 (en) * 2007-10-08 2009-04-16 Advinus Therapeutics Private Limited Acetamide derivatives as glucokinase activators, their process and medicinal applications
CL2009000004A1 (es) * 2008-01-15 2010-02-19 Lilly Co Eli Forma cristalina de r-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida; composicion farmaceutica que comprende a dicha forma cristalina; y uso para el tratamiento de diabetes o hiperglicemia.
CN101918363B (zh) 2008-01-18 2012-09-05 安斯泰来制药株式会社 苯乙酰胺衍生物
AU2009241137B2 (en) 2008-04-28 2013-10-03 Kyorin Pharmaceutical Co., Ltd. Cyclopentylacrylic acid amide derivative
ES2624780T3 (es) 2010-03-31 2017-07-17 The Scripps Research Institute Reprogramación de células

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US3776917A (en) * 1972-06-05 1973-12-04 Schering Corp 2-amino-6-phenalkyl-aminopyridines and derivatives thereof
GB8909574D0 (en) 1989-04-26 1989-06-14 Ici Plc Chemical process
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5461049A (en) * 1994-05-27 1995-10-24 Warner-Lambert Company Amide tetrazole ACAT inhibitors
US5468867A (en) * 1994-05-27 1995-11-21 Syntex (U.S.A.) Inc. Process for preparing1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl1-1H-indole-3-carboxylic acid
EP0968209A1 (en) * 1997-01-28 2000-01-05 Merck & Co., Inc. THIAZOLE BENZENESULFONAMIDES AS $g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
KR100455635B1 (ko) * 1999-03-29 2004-11-06 에프. 호프만-라 로슈 아게 글루코키나제 활성화제

Also Published As

Publication number Publication date
KR20030022408A (ko) 2003-03-15
CN1466584A (zh) 2004-01-07
ES2243541T3 (es) 2005-12-01
ZA200300904B (en) 2004-04-30
DE60111540T2 (de) 2006-03-16
JP3961948B2 (ja) 2007-08-22
AR031718A1 (es) 2003-10-01
US6369232B1 (en) 2002-04-09
CA2419416C (en) 2009-10-13
ATE297921T1 (de) 2005-07-15
AU8399801A (en) 2002-02-25
BR0113312A (pt) 2003-07-01
UY26885A1 (es) 2002-02-28
WO2002014312A1 (en) 2002-02-21
DK1311504T3 (da) 2005-10-17
CN1209362C (zh) 2005-07-06
JP2004506632A (ja) 2004-03-04
US20020035266A1 (en) 2002-03-21
US20020035267A1 (en) 2002-03-21
DE60111540D1 (de) 2005-07-21
PE20020386A1 (es) 2002-05-13
AU2001283998B2 (en) 2005-10-20
US6388088B1 (en) 2002-05-14
KR100518061B1 (ko) 2005-09-28
CA2419416A1 (en) 2002-02-21
US20020065275A1 (en) 2002-05-30
US6441180B1 (en) 2002-08-27
EP1311504A1 (en) 2003-05-21
PT1311504E (pt) 2005-10-31
EP1311504B1 (en) 2005-06-15
MXPA03001275A (es) 2003-06-30

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