PA8525201A1 - Tetrazolil-fenil acetamidas como activadores de la glucoquinasa - Google Patents

Tetrazolil-fenil acetamidas como activadores de la glucoquinasa

Info

Publication number
PA8525201A1
PA8525201A1 PA20018525201A PA8525201A PA8525201A1 PA 8525201 A1 PA8525201 A1 PA 8525201A1 PA 20018525201 A PA20018525201 A PA 20018525201A PA 8525201 A PA8525201 A PA 8525201A PA 8525201 A1 PA8525201 A1 PA 8525201A1
Authority
PA
Panama
Prior art keywords
tetrazolil
activators
glucoquinase
acetamidas
fenil
Prior art date
Application number
PA20018525201A
Other languages
English (en)
Inventor
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8525201A1 publication Critical patent/PA8525201A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LAS TETRAZOLIL-FENIL ACETAMIDAS SON ACTIVAS COMO ACTIVADORES DE LA GLUCOQUICASA, Y SON CAPACES DE AUMENTAR LA SECRECION DE LA INSULINA, LO CUAL LAS CONVIERTE EN UTILES PARA EL TRATAMIENTO DE LA DIABETES TIPO II.
PA20018525201A 2000-08-15 2001-08-14 Tetrazolil-fenil acetamidas como activadores de la glucoquinasa PA8525201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22549400P 2000-08-15 2000-08-15

Publications (1)

Publication Number Publication Date
PA8525201A1 true PA8525201A1 (es) 2002-07-30

Family

ID=22845106

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018525201A PA8525201A1 (es) 2000-08-15 2001-08-14 Tetrazolil-fenil acetamidas como activadores de la glucoquinasa

Country Status (20)

Country Link
US (3) US6369232B1 (es)
EP (1) EP1311504B1 (es)
JP (1) JP3961948B2 (es)
KR (1) KR100518061B1 (es)
CN (1) CN1209362C (es)
AR (1) AR031718A1 (es)
AT (1) ATE297921T1 (es)
AU (2) AU2001283998B2 (es)
BR (1) BR0113312A (es)
CA (1) CA2419416C (es)
DE (1) DE60111540T2 (es)
DK (1) DK1311504T3 (es)
ES (1) ES2243541T3 (es)
MX (1) MXPA03001275A (es)
PA (1) PA8525201A1 (es)
PE (1) PE20020386A1 (es)
PT (1) PT1311504E (es)
UY (1) UY26885A1 (es)
WO (1) WO2002014312A1 (es)
ZA (1) ZA200300904B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7078423B2 (en) * 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
US7087631B2 (en) * 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
AU2003302279B2 (en) * 2002-10-03 2008-06-12 Novartis Ag Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of Type 2 diabetes
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
MY141521A (en) 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
WO2004063194A1 (en) * 2003-01-06 2004-07-29 Eli Lilly And Company Heteroaryl compounds
WO2004072066A1 (en) * 2003-02-11 2004-08-26 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
RU2006138426A (ru) 2004-04-02 2008-05-10 Новартис АГ (CH) Производные тиазолопиридина, содержащие их фармацевтические композиции и способы лечения состояний, опосредованных глюкокиназой
CN1960995B (zh) 2004-04-02 2010-12-08 诺瓦提斯公司 作为葡糖激酶活化剂、可用于治疗ⅱ型糖尿病的磺酰胺-噻唑并吡啶衍生物
MX2008000560A (es) 2005-07-11 2008-03-10 Mitsubishi Tanabe Pharma Corp Un derivado de oxima y sus preparaciones.
CA2621227A1 (en) 2005-08-31 2007-03-08 Astellas Pharma Inc. Thiazole derivative
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CA2624102A1 (en) 2005-09-29 2007-04-12 Sanofi-Aventis Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
GT200600429A (es) 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) 2005-09-30 2007-05-21 Compuestos organicos
JP2009514835A (ja) * 2005-11-03 2009-04-09 プロシディオン・リミテッド トリシクロ置換型アミド
JP2009515997A (ja) * 2005-11-18 2009-04-16 タケダ サン ディエゴ インコーポレイテッド グルコキナーゼ活性剤
ES2381864T3 (es) * 2005-12-15 2012-06-01 Nihon Nohyaku Co., Ltd. Derivado de ftalamida, pesticida agrícola u hortícola y utilización del pesticida
WO2007104034A2 (en) 2006-03-08 2007-09-13 Takeda San Diego, Inc. Glucokinase activators
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
ATE522518T1 (de) * 2006-05-31 2011-09-15 Takeda San Diego Inc Indazol- und isoindolderivate als glucokinaseaktivierende stoffe
US7910747B2 (en) * 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
US7902248B2 (en) 2006-12-14 2011-03-08 Hoffmann-La Roche Inc. Oxime glucokinase activators
EP2091947A2 (en) 2006-12-20 2009-08-26 Takeda San Diego, Inc. Glucokinase activators
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
EP2105435A4 (en) * 2007-01-10 2011-06-15 Mitsubishi Tanabe Pharma Corp Hydrazone derivatives
US8034819B2 (en) 2007-03-07 2011-10-11 Kyorin Pharmaceutical Co., Ltd. Glucokinase activator
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
EP2195304B1 (en) * 2007-10-08 2014-01-08 Advinus Therapeutics Private Limited Acetamide derivatives as glucokinase activators, their process and medicinal applications
PE20091313A1 (es) * 2008-01-15 2009-09-03 Lilly Co Eli (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina
CN101918363B (zh) 2008-01-18 2012-09-05 安斯泰来制药株式会社 苯乙酰胺衍生物
PL2275414T3 (pl) 2008-04-28 2016-01-29 Kyorin Seiyaku Kk Pochodne cyklopentyloakryloamidu
CN105176930B (zh) 2010-03-31 2021-05-04 斯克里普斯研究所 重编程细胞

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776917A (en) * 1972-06-05 1973-12-04 Schering Corp 2-amino-6-phenalkyl-aminopyridines and derivatives thereof
GB8909574D0 (en) 1989-04-26 1989-06-14 Ici Plc Chemical process
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5468867A (en) * 1994-05-27 1995-11-21 Syntex (U.S.A.) Inc. Process for preparing1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl1-1H-indole-3-carboxylic acid
US5461049A (en) * 1994-05-27 1995-10-24 Warner-Lambert Company Amide tetrazole ACAT inhibitors
AU728812B2 (en) * 1997-01-28 2001-01-18 Merck & Co., Inc. Thiazole benzenesulfonamides as beta3 agonists for the treatment of diabetes and obesity
SI1169312T1 (en) * 1999-03-29 2005-02-28 F. Hoffmann-La Roche Ag Glucokinase activators

Also Published As

Publication number Publication date
JP2004506632A (ja) 2004-03-04
AU2001283998B2 (en) 2005-10-20
AR031718A1 (es) 2003-10-01
US20020065275A1 (en) 2002-05-30
DE60111540T2 (de) 2006-03-16
US6441180B1 (en) 2002-08-27
KR100518061B1 (ko) 2005-09-28
BR0113312A (pt) 2003-07-01
PE20020386A1 (es) 2002-05-13
AU8399801A (en) 2002-02-25
ZA200300904B (en) 2004-04-30
CN1466584A (zh) 2004-01-07
US20020035267A1 (en) 2002-03-21
ATE297921T1 (de) 2005-07-15
CA2419416C (en) 2009-10-13
ES2243541T3 (es) 2005-12-01
US6369232B1 (en) 2002-04-09
EP1311504A1 (en) 2003-05-21
PT1311504E (pt) 2005-10-31
CA2419416A1 (en) 2002-02-21
UY26885A1 (es) 2002-02-28
DE60111540D1 (de) 2005-07-21
US20020035266A1 (en) 2002-03-21
DK1311504T3 (da) 2005-10-17
CN1209362C (zh) 2005-07-06
MXPA03001275A (es) 2003-06-30
US6388088B1 (en) 2002-05-14
WO2002014312A1 (en) 2002-02-21
KR20030022408A (ko) 2003-03-15
JP3961948B2 (ja) 2007-08-22
EP1311504B1 (en) 2005-06-15

Similar Documents

Publication Publication Date Title
PA8525201A1 (es) Tetrazolil-fenil acetamidas como activadores de la glucoquinasa
ECSP014054A (es) Activadores de glucoquinasa alquinil fenil heteroaromatica
ECSP014055A (es) Activadores de glucoquinasa que contienen hidantoina
UY26694A1 (es) Activadores de fenil glucocinasa para - arilo o hetero sustituidos
PA8534601A1 (es) Activadores de glucocinasa del tipo isoindolin-1-ona
ECSP045382A (es) Fenilacetamidas sustituidas y su uso como activadores de glucoquinasa
PA8584001A1 (es) Indol-3-carboxamidas como activadores de glucoquinasa (gk)
CR20110477A (es) Inhibidores de enzimas de proteina cinasa activadas por mitogeno p38
PA8600601A1 (es) Ligandos de receptores de cannabinoides y sus usos
UY29249A1 (es) Agentes citotóxicos que comprenden taxanos nuevos
ATE531382T1 (de) Behandlungsmethoden von entzündungskrankheiten mit spezifisch an menschliches angiopoietin-2 bindenden wirkstoffen
DOP2006000052A (es) Alargar el tiempo hasta la progresión de la enfermedad o la supervivencia de los pacientes de cáncer
CL2008001197A1 (es) Compuestos derivados de amidas sustituidas, moduladoras de la actividad de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo i; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como sindrome metabolico, resistencia a la insulina, dislipidemia, entre otras.
EA200900392A1 (ru) Комбинированное лечение сахарного диабета
ECSP105178A (es) Compuestos de aril urea en combinación con otros agentes citostáticos o citotóxicos para el tratamiento de cáncer en humanos
EA201170149A1 (ru) Новые аналоги инсулина пролонгированной активности
ATE494280T1 (de) Stereoisomerisch angereicherte 3-aminocarbonyl- bicyclohepten-pyrimidindiamin-verbindungen und ihre verwendungen
UY28731A1 (es) Compuestos quimicos
UY29250A1 (es) Agentes citotóxicos que comprenden nuevos taxanos modificados en c-2.-
NI201000015A (es) Bromhidrato de bupropión y aplicaciones terapéuticas
TR201901390T4 (tr) Demodikoza karşı madde.
EA200701592A1 (ru) Композиты и способы их получения и использования
UY29189A1 (es) Nonadepsipeptidos acilados ii
ATE534649T1 (de) Imidazothiazole und imidazoxazolderivative als inhibitoren von p38
UY37680A (es) Proteína de fusión con polipéptido de extensión de vida media