PA8534601A1 - Activadores de glucocinasa del tipo isoindolin-1-ona - Google Patents

Activadores de glucocinasa del tipo isoindolin-1-ona

Info

Publication number
PA8534601A1
PA8534601A1 PA20018534601A PA8534601A PA8534601A1 PA 8534601 A1 PA8534601 A1 PA 8534601A1 PA 20018534601 A PA20018534601 A PA 20018534601A PA 8534601 A PA8534601 A PA 8534601A PA 8534601 A1 PA8534601 A1 PA 8534601A1
Authority
PA
Panama
Prior art keywords
isoindolin
ona
type
glucocinase
activators
Prior art date
Application number
PA20018534601A
Other languages
English (en)
Inventor
Kevin Richard Guertin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8534601A1 publication Critical patent/PA8534601A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

ACTIVADORES DE GLUCOCINASA DEL TIPO PROPIONAMIDA SUSTITUIDA POR ISOINDOLIN-1-ONA PARA AUMENTAR LA SECRECION DE INSULINA EN EL TRATAMIENTO DE LA DIABETES II.
PA20018534601A 2000-12-13 2001-12-10 Activadores de glucocinasa del tipo isoindolin-1-ona PA8534601A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25527300P 2000-12-13 2000-12-13
US31871501P 2001-09-13 2001-09-13

Publications (1)

Publication Number Publication Date
PA8534601A1 true PA8534601A1 (es) 2002-08-26

Family

ID=26944583

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018534601A PA8534601A1 (es) 2000-12-13 2001-12-10 Activadores de glucocinasa del tipo isoindolin-1-ona

Country Status (36)

Country Link
US (1) US6482951B2 (es)
EP (1) EP1349856B1 (es)
JP (1) JP4021766B2 (es)
KR (1) KR100520651B1 (es)
CN (1) CN1247574C (es)
AT (1) ATE297922T1 (es)
AU (2) AU2002238415B2 (es)
BG (1) BG107903A (es)
BR (1) BR0116169A (es)
CA (1) CA2430579C (es)
CY (1) CY1105587T1 (es)
CZ (1) CZ20031882A3 (es)
DE (1) DE60111570T2 (es)
DK (1) DK1349856T3 (es)
EG (1) EG24358A (es)
ES (1) ES2243578T3 (es)
HK (1) HK1063314A1 (es)
HR (1) HRP20030450B1 (es)
HU (1) HUP0400587A3 (es)
IL (2) IL156264A0 (es)
MA (1) MA26973A1 (es)
MX (1) MXPA03005170A (es)
MY (1) MY136741A (es)
NO (1) NO325810B1 (es)
NZ (1) NZ526236A (es)
PA (1) PA8534601A1 (es)
PE (1) PE20020593A1 (es)
PL (1) PL366006A1 (es)
PT (1) PT1349856E (es)
RS (1) RS50933B (es)
RU (1) RU2249590C2 (es)
SI (1) SI1349856T1 (es)
SK (1) SK8732003A3 (es)
TW (1) TWI294876B (es)
UY (1) UY27069A1 (es)
WO (1) WO2002048106A2 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
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SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
KR20050074959A (ko) 2002-10-03 2005-07-19 노파르티스 아게 제ｉｉ형 당뇨병 치료에 유용한 글루코키나아제 활성인자로서의 치환된 (티아졸-２-일)-아미드 또는 술폰아미드
KR100646486B1 (ko) 2002-10-03 2006-11-15 에프. 호프만-라 로슈 아게 글루코키나제(ｇｋ) 활성제로서 인돌-3-카복스아미드
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
AU2003294376A1 (en) * 2003-01-06 2004-08-10 Eli Lilly And Company Heteroaryl compounds
EP1594863A1 (en) * 2003-02-11 2005-11-16 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US7781451B2 (en) * 2004-04-02 2010-08-24 Novartis Ag Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
BRPI0509573A (pt) 2004-04-02 2007-09-25 Novartis Ag derivados de sulfonamida-tiazolpiridina como ativadores de glicocinase úteis para o tratamento de diabetes do tipo 2
US20090281142A1 (en) * 2005-08-31 2009-11-12 Astellas Pharma Inc. Thiazole derivative
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CN101272784A (zh) 2005-09-29 2008-09-24 塞诺菲-安万特股份有限公司 苯基-和吡啶基-1,2,4-噁二唑酮衍生物、它们的制备方法和它们作为药物的用途
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
CA2627910A1 (en) * 2005-11-01 2007-05-10 Janssen Pharmaceutica N.V. Substituted cycloalkylpyrrolones as allosteric modulators of glucokinase
CA2628259A1 (en) 2005-11-01 2007-05-10 Janssen Pharmaceutica N.V. Dihydroisoindolones as allosteric modulators of glucokinase
EP1960385A1 (en) * 2005-11-01 2008-08-27 Janssen Pharmaceutica N.V. Substituted dihydroisoindolones as allosteric modulators of glucokinase
CA2627813A1 (en) * 2005-11-01 2007-05-10 Janssen Pharmaceutica N.V. Substituted pyrrolones as allosteric modulators of glucokinase
EP1948644A1 (en) * 2005-11-03 2008-07-30 Prosidion Limited Tricyclo substituted amides
WO2007061923A2 (en) * 2005-11-18 2007-05-31 Takeda San Diego, Inc. Glucokinase activators
US8034822B2 (en) 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2049518B1 (en) * 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.
WO2008074694A1 (en) * 2006-12-20 2008-06-26 F. Hoffmann-La Roche Ag Crystallization of glucokinase activators
EP2091947A2 (en) * 2006-12-20 2009-08-26 Takeda San Diego, Inc. Glucokinase activators
TW200831081A (en) * 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
JP5248477B2 (ja) * 2007-03-07 2013-07-31 杏林製薬株式会社 グルコキナーゼ活性化物質
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
PE20091313A1 (es) * 2008-01-15 2009-09-03 Lilly Co Eli (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina
BRPI0821827A2 (pt) * 2008-01-24 2015-06-16 Merck Patent Ges Mit Beschränkter Haftung Derivados de beta-aminoácidos para tratamento de diabetes
SI2275414T1 (sl) 2008-04-28 2015-10-30 Kyorin Pharmaceutical Co., Ltd., Ciklopentilakrilamidni derivat
CL2009001203A1 (es) 2008-05-16 2009-10-23 Takeda San Diego Inc Compuestos derivados de indazol y pirazol sustituidos; composicion farmaceutica de dichos compuestos; kit farmaceutico; y su uso como activadores de la glucoquinasa para tratar enfermedades metabolicas tales como hiperglicemia, diabetes, dislipidemias, obesidad, sindrome metabolico x y enfermedades cardiovasculares.
PE20110303A1 (es) * 2008-09-11 2011-05-21 Pfizer Derivados de heteroaril acetamidas como activadores de glucoquinasa
WO2011123572A1 (en) 2010-03-31 2011-10-06 The Scripps Research Institute Reprogramming cells
US8178689B2 (en) * 2010-06-17 2012-05-15 Hoffman-La Roche Inc. Tricyclic compounds
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
US8470866B2 (en) * 2011-05-03 2013-06-25 Hoffmann-La Roche Inc. Isoindolinone derivatives
RS59663B1 (sr) * 2013-05-27 2020-01-31 Hoffmann La Roche Nova jedinjenja 3,4-dihidro-2h-izokinolin-1-on i 2,3-dihidro-izoindol-1-on
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
AU2015308350B2 (en) 2014-08-29 2020-03-05 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
MX2021005904A (es) 2018-11-20 2021-09-08 Tes Pharma S R L Inhibidores de la ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa.

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FR2687147A1 (fr) * 1992-02-11 1993-08-13 Union Pharma Scient Appl Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
ATE278680T1 (de) 1999-03-29 2004-10-15 Hoffmann La Roche Glukokinase aktivatoren
ATE304011T1 (de) 2000-05-03 2005-09-15 Hoffmann La Roche Hydantoin-enthaltende glucokinase aktivatoren
DE60106599T2 (de) 2000-05-08 2006-02-09 F. Hoffmann-La Roche Ag Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren

Also Published As

Publication number Publication date
HUP0400587A2 (hu) 2004-06-28
CA2430579C (en) 2010-01-26
RU2249590C2 (ru) 2005-04-10
EG24358A (en) 2009-03-04
WO2002048106A3 (en) 2002-11-28
NO20032674L (no) 2003-06-12
HUP0400587A3 (en) 2011-03-28
WO2002048106A2 (en) 2002-06-20
CY1105587T1 (el) 2010-07-28
AU3841502A (en) 2002-06-24
BR0116169A (pt) 2003-12-23
EP1349856A2 (en) 2003-10-08
CA2430579A1 (en) 2002-06-20
MXPA03005170A (es) 2003-09-22
KR20030064817A (ko) 2003-08-02
JP4021766B2 (ja) 2007-12-12
YU47703A (sh) 2006-05-25
SI1349856T1 (en) 2005-10-31
IL156264A (en) 2010-11-30
IL156264A0 (en) 2004-01-04
BG107903A (bg) 2004-02-27
DE60111570T2 (de) 2006-05-11
CN1247574C (zh) 2006-03-29
CN1481382A (zh) 2004-03-10
NZ526236A (en) 2004-12-24
HRP20030450A2 (en) 2005-04-30
JP2004521095A (ja) 2004-07-15
US20020082260A1 (en) 2002-06-27
NO20032674D0 (no) 2003-06-12
PL366006A1 (en) 2005-01-24
MY136741A (en) 2008-11-28
PE20020593A1 (es) 2002-07-06
HRP20030450B1 (en) 2006-02-28
CZ20031882A3 (cs) 2003-12-17
RS50933B (sr) 2010-08-31
DE60111570D1 (de) 2005-07-21
TWI294876B (en) 2008-03-21
PT1349856E (pt) 2005-09-30
KR100520651B1 (ko) 2005-10-11
US6482951B2 (en) 2002-11-19
MA26973A1 (fr) 2004-12-20
DK1349856T3 (da) 2005-10-17
ES2243578T3 (es) 2005-12-01
SK8732003A3 (en) 2004-04-06
ATE297922T1 (de) 2005-07-15
NO325810B1 (no) 2008-07-21
EP1349856B1 (en) 2005-06-15
AU2002238415B2 (en) 2007-01-04
HK1063314A1 (en) 2004-12-24
UY27069A1 (es) 2002-07-31

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