NO20032674L - Isoindolin-1-on-glukokinase-aktivatorer - Google Patents

Isoindolin-1-on-glukokinase-aktivatorer

Info

Publication number
NO20032674L
NO20032674L NO20032674A NO20032674A NO20032674L NO 20032674 L NO20032674 L NO 20032674L NO 20032674 A NO20032674 A NO 20032674A NO 20032674 A NO20032674 A NO 20032674A NO 20032674 L NO20032674 L NO 20032674L
Authority
NO
Norway
Prior art keywords
isoindoline
glucokinase activators
glucokinase
activators
isoindolin
Prior art date
Application number
NO20032674A
Other languages
English (en)
Other versions
NO325810B1 (no
NO20032674D0 (no
Inventor
Kevin Richard Guertin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20032674D0 publication Critical patent/NO20032674D0/no
Publication of NO20032674L publication Critical patent/NO20032674L/no
Publication of NO325810B1 publication Critical patent/NO325810B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
NO20032674A 2000-12-13 2003-06-12 Isoindolin-1-onderivater, farmasoytiske forbindelser inneholdende slike, fremgangsmate for fremstilling av disse, slike forbindelser for anvendelse som legemiddel samt anvendelse av disse for fremstilling av medikament for behandling av diabetes NO325810B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25527300P 2000-12-13 2000-12-13
US31871501P 2001-09-13 2001-09-13
PCT/EP2001/014404 WO2002048106A2 (en) 2000-12-13 2001-12-07 Isoindolin-1-one glucokinase activators

Publications (3)

Publication Number Publication Date
NO20032674D0 NO20032674D0 (no) 2003-06-12
NO20032674L true NO20032674L (no) 2003-06-12
NO325810B1 NO325810B1 (no) 2008-07-21

Family

ID=26944583

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032674A NO325810B1 (no) 2000-12-13 2003-06-12 Isoindolin-1-onderivater, farmasoytiske forbindelser inneholdende slike, fremgangsmate for fremstilling av disse, slike forbindelser for anvendelse som legemiddel samt anvendelse av disse for fremstilling av medikament for behandling av diabetes

Country Status (36)

Country Link
US (1) US6482951B2 (no)
EP (1) EP1349856B1 (no)
JP (1) JP4021766B2 (no)
KR (1) KR100520651B1 (no)
CN (1) CN1247574C (no)
AT (1) ATE297922T1 (no)
AU (2) AU2002238415B2 (no)
BG (1) BG107903A (no)
BR (1) BR0116169A (no)
CA (1) CA2430579C (no)
CY (1) CY1105587T1 (no)
CZ (1) CZ20031882A3 (no)
DE (1) DE60111570T2 (no)
DK (1) DK1349856T3 (no)
EG (1) EG24358A (no)
ES (1) ES2243578T3 (no)
HK (1) HK1063314A1 (no)
HR (1) HRP20030450B1 (no)
HU (1) HUP0400587A3 (no)
IL (2) IL156264A0 (no)
MA (1) MA26973A1 (no)
MX (1) MXPA03005170A (no)
MY (1) MY136741A (no)
NO (1) NO325810B1 (no)
NZ (1) NZ526236A (no)
PA (1) PA8534601A1 (no)
PE (1) PE20020593A1 (no)
PL (1) PL366006A1 (no)
PT (1) PT1349856E (no)
RS (1) RS50933B (no)
RU (1) RU2249590C2 (no)
SI (1) SI1349856T1 (no)
SK (1) SK8732003A3 (no)
TW (1) TWI294876B (no)
UY (1) UY27069A1 (no)
WO (1) WO2002048106A2 (no)

Families Citing this family (46)

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SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
BR0315047A (pt) 2002-10-03 2005-08-23 Hoffmann La Roche Composto, composição fermacêutica que compreende o mesmo, processo para a preparação da composição farmacêutica, utilização dos compostos, método de tratamento e processo para a preparação do composto
KR20050074959A (ko) 2002-10-03 2005-07-19 노파르티스 아게 제ii형 당뇨병 치료에 유용한 글루코키나아제 활성인자로서의 치환된 (티아졸-2-일)-아미드 또는 술폰아미드
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
WO2004063194A1 (en) * 2003-01-06 2004-07-29 Eli Lilly And Company Heteroaryl compounds
EP1594863A1 (en) * 2003-02-11 2005-11-16 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
CN101098876A (zh) * 2004-04-02 2008-01-02 诺瓦提斯公司 噻唑并吡啶衍生物、包含它们的药物形式以及治疗葡糖激酶介导的病症的方法
ATE524479T1 (de) 2004-04-02 2011-09-15 Novartis Ag Sulfonamidthiazolpyridinderivate als zur behandlung von typ-2-diabetes geeignete glucokinaseaktivatoren
RU2008112184A (ru) * 2005-08-31 2009-10-10 Астеллас Фарма Инк. (Jp) Производное тиазола
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
AU2006299091A1 (en) 2005-09-29 2007-04-12 Sanofi-Aventis Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
US7531671B2 (en) 2005-11-01 2009-05-12 Janssen Pharmaceutica N.V. Dihydroisoindolones as allosteric modulators of glucokinase
CN101316837A (zh) * 2005-11-01 2008-12-03 詹森药业有限公司 作为葡萄糖激酶变构调节剂的取代的吡咯酮类
EP1960386A2 (en) * 2005-11-01 2008-08-27 Janssen Pharmaceutica N.V. Substituted cycloalkylpyrrolones as allosteric modulators of glucokinase
CA2627892A1 (en) 2005-11-01 2007-05-10 Janssen Pharmaceutica N.V. Substituted dihydroisoindolones as allosteric modulators of glucokinase
JP2009514835A (ja) * 2005-11-03 2009-04-09 プロシディオン・リミテッド トリシクロ置換型アミド
US20070197532A1 (en) * 2005-11-18 2007-08-23 Cao Sheldon X Glucokinase activators
EP2001875A2 (en) 2006-03-08 2008-12-17 Takeda San Diego, Inc. Glucokinase activators
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
US8008332B2 (en) 2006-05-31 2011-08-30 Takeda San Diego, Inc. Substituted indazoles as glucokinase activators
JP5419706B2 (ja) * 2006-12-20 2014-02-19 タケダ カリフォルニア インコーポレイテッド グルコキナーゼアクチベーター
WO2008074694A1 (en) * 2006-12-20 2008-06-26 F. Hoffmann-La Roche Ag Crystallization of glucokinase activators
TW200831081A (en) * 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
WO2008111473A1 (ja) 2007-03-07 2008-09-18 Kyorin Pharmaceutical Co., Ltd. グルコキナーゼ活性化物質
WO2008116107A2 (en) * 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
PE20091313A1 (es) * 2008-01-15 2009-09-03 Lilly Co Eli (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina
PL2231640T3 (pl) * 2008-01-24 2012-09-28 Merck Patent Gmbh Pochodne beta-aminokwasowe do leczenia cukrzycy
MX2010011778A (es) 2008-04-28 2010-11-30 Kyorin Seiyaku Kk Derivados de ciclopentil acrilamida.
KR20110018366A (ko) 2008-05-16 2011-02-23 다케다 샌디에고, 인코포레이티드 글루코키나아제 활성제
GEP20135793B (en) * 2008-09-11 2013-03-25 Pfizer Heteroaryls amide derivatives and their use as glucokinase activators
EP3936608A1 (en) 2010-03-31 2022-01-12 The Scripps Research Institute Reprogramming cells
US8178689B2 (en) * 2010-06-17 2012-05-15 Hoffman-La Roche Inc. Tricyclic compounds
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2681236B1 (en) 2011-03-01 2018-01-03 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
US8470866B2 (en) * 2011-05-03 2013-06-25 Hoffmann-La Roche Inc. Isoindolinone derivatives
RU2693698C2 (ru) * 2013-05-27 2019-07-04 Ф. Хоффманн-Ля Рош Аг Новые соединения 3,4-дигидро-2н-изохинолин-1-она и 2,3-дигидроизоиндол-1-она
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
ES2901114T3 (es) 2014-08-29 2022-03-21 Tes Pharma S R L Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
AU2019385644A1 (en) 2018-11-20 2021-06-03 Tes Pharma S.R.L. Inhibitors of α-Amino-β-carboxymuconic acid semialdehyde decarboxylase

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Publication number Priority date Publication date Assignee Title
FR2687147A1 (fr) * 1992-02-11 1993-08-13 Union Pharma Scient Appl Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
ATE278680T1 (de) 1999-03-29 2004-10-15 Hoffmann La Roche Glukokinase aktivatoren
ES2248309T3 (es) 2000-05-03 2006-03-16 F. Hoffmann-La Roche Ag Activadores de glucoquinasa conteniendo hidantoina.
BR0110704A (pt) 2000-05-08 2003-01-28 Hoffmann La Roche Fenil - acetamidas substituìdas e seu uso como ativadores de glicocinase

Also Published As

Publication number Publication date
SI1349856T1 (en) 2005-10-31
US20020082260A1 (en) 2002-06-27
HUP0400587A2 (hu) 2004-06-28
JP2004521095A (ja) 2004-07-15
IL156264A (en) 2010-11-30
PL366006A1 (en) 2005-01-24
NZ526236A (en) 2004-12-24
NO325810B1 (no) 2008-07-21
CA2430579C (en) 2010-01-26
HRP20030450A2 (en) 2005-04-30
WO2002048106A2 (en) 2002-06-20
BR0116169A (pt) 2003-12-23
IL156264A0 (en) 2004-01-04
AU3841502A (en) 2002-06-24
US6482951B2 (en) 2002-11-19
MXPA03005170A (es) 2003-09-22
HRP20030450B1 (en) 2006-02-28
EG24358A (en) 2009-03-04
YU47703A (sh) 2006-05-25
CA2430579A1 (en) 2002-06-20
CZ20031882A3 (cs) 2003-12-17
NO20032674D0 (no) 2003-06-12
CY1105587T1 (el) 2010-07-28
PT1349856E (pt) 2005-09-30
BG107903A (bg) 2004-02-27
PE20020593A1 (es) 2002-07-06
UY27069A1 (es) 2002-07-31
CN1247574C (zh) 2006-03-29
DK1349856T3 (da) 2005-10-17
MY136741A (en) 2008-11-28
RU2249590C2 (ru) 2005-04-10
MA26973A1 (fr) 2004-12-20
TWI294876B (en) 2008-03-21
SK8732003A3 (en) 2004-04-06
JP4021766B2 (ja) 2007-12-12
KR100520651B1 (ko) 2005-10-11
CN1481382A (zh) 2004-03-10
PA8534601A1 (es) 2002-08-26
WO2002048106A3 (en) 2002-11-28
KR20030064817A (ko) 2003-08-02
ES2243578T3 (es) 2005-12-01
EP1349856B1 (en) 2005-06-15
HUP0400587A3 (en) 2011-03-28
HK1063314A1 (en) 2004-12-24
DE60111570D1 (de) 2005-07-21
DE60111570T2 (de) 2006-05-11
AU2002238415B2 (en) 2007-01-04
RS50933B (sr) 2010-08-31
EP1349856A2 (en) 2003-10-08
ATE297922T1 (de) 2005-07-15

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