ECSP014055A - Activadores de glucoquinasa que contienen hidantoina - Google Patents
Activadores de glucoquinasa que contienen hidantoinaInfo
- Publication number
- ECSP014055A ECSP014055A EC2001004055A ECSP014055A ECSP014055A EC SP014055 A ECSP014055 A EC SP014055A EC 2001004055 A EC2001004055 A EC 2001004055A EC SP014055 A ECSP014055 A EC SP014055A EC SP014055 A ECSP014055 A EC SP014055A
- Authority
- EC
- Ecuador
- Prior art keywords
- glucoquinase
- activators containing
- containing hydantoin
- hydantoin
- activators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Compuestos de hidantoína que son activos como activadores de la glucoquinasa para aumentar la secreción de insulina, lo cual los hace útiles para el tratamiento de la diabetes tipo II.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20149800P | 2000-05-03 | 2000-05-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP014055A true ECSP014055A (es) | 2002-01-25 |
Family
ID=22746054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2001004055A ECSP014055A (es) | 2000-05-03 | 2001-05-03 | Activadores de glucoquinasa que contienen hidantoina |
Country Status (20)
Country | Link |
---|---|
US (2) | US6583288B2 (es) |
EP (1) | EP1280801B1 (es) |
JP (1) | JP3842131B2 (es) |
KR (1) | KR100505312B1 (es) |
CN (1) | CN1209361C (es) |
AR (1) | AR034253A1 (es) |
AT (1) | ATE304011T1 (es) |
AU (2) | AU5227001A (es) |
BR (1) | BR0110492A (es) |
CA (1) | CA2407428C (es) |
DE (1) | DE60113247T2 (es) |
DK (1) | DK1280801T3 (es) |
EC (1) | ECSP014055A (es) |
ES (1) | ES2248309T3 (es) |
MX (1) | MXPA02010746A (es) |
PE (1) | PE20011313A1 (es) |
PT (1) | PT1280801E (es) |
UY (1) | UY26689A1 (es) |
WO (1) | WO2001083478A2 (es) |
ZA (1) | ZA200208370B (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE304011T1 (de) * | 2000-05-03 | 2005-09-15 | Hoffmann La Roche | Hydantoin-enthaltende glucokinase aktivatoren |
US6482951B2 (en) | 2000-12-13 | 2002-11-19 | Hoffmann-La Roche Inc. | Isoindolin-1-one glucokinase activators |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
CZ2004747A3 (cs) | 2001-12-21 | 2004-11-10 | Novo Nordisk A/S | Deriváty amidů jako GK aktivátory |
MXPA05000130A (es) | 2002-06-27 | 2005-02-17 | Novo Nordisk As | Derivados de aril-carbonilo como agentes terapeuticos. |
RU2340605C2 (ru) | 2002-06-27 | 2008-12-10 | Ново Нордиск А/С | Арилкарбонильные производные в качестве терапевтических средств |
NZ539013A (en) | 2002-10-03 | 2007-05-31 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
US7132425B2 (en) * | 2002-12-12 | 2006-11-07 | Hoffmann-La Roche Inc. | 5-substituted-six-membered heteroaromatic glucokinase activators |
PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
JP4621198B2 (ja) * | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ(シクロ)置換アミドグルコキナーゼ活性化化合物 |
CN1910166B (zh) * | 2004-01-06 | 2012-01-04 | 诺和诺德公司 | 杂芳基脲及其作为葡糖激酶活化剂的用途 |
WO2005066145A1 (en) | 2004-01-06 | 2005-07-21 | Novo Nordisk A/S | Heteroaryl-ureas and their use as glucokinase activators |
AU2005229416B2 (en) | 2004-04-02 | 2009-03-26 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of type 2 diabetes |
EP1737870A1 (en) | 2004-04-02 | 2007-01-03 | Novartis AG | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
AU2005274390B2 (en) | 2004-08-17 | 2012-01-19 | F. Hoffmann-La Roche Ag | Substituted hydantoins |
US7696192B2 (en) | 2004-09-09 | 2010-04-13 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirolactam CGRP receptor antagonists |
US8003792B2 (en) | 2004-09-13 | 2011-08-23 | Merck Sharp & Dohme Corp. | Bicyclic anilide spirolactam CGRP receptor antagonists |
US7390798B2 (en) * | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
TW200621766A (en) | 2004-09-17 | 2006-07-01 | Hoffmann La Roche | Substituted hydantoins |
WO2007006760A1 (en) | 2005-07-08 | 2007-01-18 | Novo Nordisk A/S | Dicycloalkyl urea glucokinase activators |
EP1910317B1 (en) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino linked compounds |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
NZ566877A (en) | 2005-09-29 | 2010-05-28 | Sanofi Aventis | Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
WO2007123581A1 (en) | 2005-11-17 | 2007-11-01 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
EP1948614A2 (en) * | 2005-11-18 | 2008-07-30 | Takeda San Diego, Inc. | Glucokinase activators |
FR2894962B1 (fr) * | 2005-12-20 | 2008-03-14 | Pharmamens Sarl | Hydantoines a action insulinotropique |
US7612212B2 (en) | 2006-02-22 | 2009-11-03 | Hoffmann-La Roche Inc. | Substituted hydantoins |
JP5302012B2 (ja) * | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
WO2007143434A2 (en) | 2006-05-31 | 2007-12-13 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents |
US20080107725A1 (en) * | 2006-10-13 | 2008-05-08 | Albano Antonio A | Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers |
WO2008079787A2 (en) * | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
MX2009009525A (es) * | 2007-03-07 | 2009-09-16 | Kyorin Seiyaku Kk | Activador de glucocinasa. |
CA2680307A1 (en) * | 2007-03-12 | 2008-09-18 | Merck & Co., Inc. | Monocyclic anilide spirolactam cgrp receptor antagonists |
WO2008116107A2 (en) | 2007-03-21 | 2008-09-25 | Takeda San Diego, Inc. | Piperazine derivatives as glucokinase activators |
KR101147583B1 (ko) * | 2007-08-16 | 2012-05-21 | 에프. 호프만-라 로슈 아게 | 치환 히단토인 |
CN101896469A (zh) | 2007-12-20 | 2010-11-24 | 霍夫曼-拉罗奇有限公司 | 作为mek激酶抑制剂的取代的乙内酰脲类化合物 |
US8258134B2 (en) * | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
KR101608259B1 (ko) | 2008-04-28 | 2016-04-01 | 교린 세이야꾸 가부시키 가이샤 | 시클로펜틸아크릴산아미드 유도체 |
UY31830A (es) | 2008-05-16 | 2010-01-05 | Takeda Pharmaceutical | Activadores de glucoquinasa |
US8450494B2 (en) | 2009-06-22 | 2013-05-28 | Cadila Healthcare Limited | Disubstituted benzamide derivatives as glucokinase (GK) activators |
JP2013500961A (ja) | 2009-07-31 | 2013-01-10 | カディラ ヘルスケア リミテッド | グルコキナーゼ(gk)アクチベーターとしての置換ベンズアミド誘導体 |
JP5909482B2 (ja) | 2010-03-31 | 2016-04-26 | ザ スクリプス リサーチ インスティテュート | 細胞の再プログラム |
ES2671881B1 (es) * | 2016-11-11 | 2019-03-25 | Consejo Superior Investigacion | Procedimiento de obtencion de polimeros con grupos isocianato |
CN112040945A (zh) | 2018-06-12 | 2020-12-04 | Vtv治疗有限责任公司 | 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5202339A (en) * | 1987-08-28 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Hydantoin derivatives |
US6320050B1 (en) * | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
ATE304011T1 (de) * | 2000-05-03 | 2005-09-15 | Hoffmann La Roche | Hydantoin-enthaltende glucokinase aktivatoren |
-
2001
- 2001-04-23 AT AT01925563T patent/ATE304011T1/de not_active IP Right Cessation
- 2001-04-23 KR KR10-2002-7014735A patent/KR100505312B1/ko not_active IP Right Cessation
- 2001-04-23 MX MXPA02010746A patent/MXPA02010746A/es active IP Right Grant
- 2001-04-23 CN CNB018089135A patent/CN1209361C/zh not_active Expired - Fee Related
- 2001-04-23 AU AU5227001A patent/AU5227001A/xx active Pending
- 2001-04-23 EP EP01925563A patent/EP1280801B1/en not_active Expired - Lifetime
- 2001-04-23 ES ES01925563T patent/ES2248309T3/es not_active Expired - Lifetime
- 2001-04-23 JP JP2001580906A patent/JP3842131B2/ja not_active Expired - Fee Related
- 2001-04-23 WO PCT/EP2001/004555 patent/WO2001083478A2/en active IP Right Grant
- 2001-04-23 DK DK01925563T patent/DK1280801T3/da active
- 2001-04-23 DE DE60113247T patent/DE60113247T2/de not_active Expired - Lifetime
- 2001-04-23 CA CA002407428A patent/CA2407428C/en not_active Expired - Fee Related
- 2001-04-23 BR BR0110492-6A patent/BR0110492A/pt not_active Application Discontinuation
- 2001-04-23 PT PT01925563T patent/PT1280801E/pt unknown
- 2001-04-23 AU AU2001252270A patent/AU2001252270B2/en not_active Ceased
- 2001-04-26 US US09/843,466 patent/US6583288B2/en not_active Expired - Fee Related
- 2001-04-30 PE PE2001000389A patent/PE20011313A1/es not_active Application Discontinuation
- 2001-04-30 AR ARP010102036A patent/AR034253A1/es unknown
- 2001-05-02 UY UY26689A patent/UY26689A1/es not_active Application Discontinuation
- 2001-05-03 EC EC2001004055A patent/ECSP014055A/es unknown
-
2002
- 2002-10-17 ZA ZA200208370A patent/ZA200208370B/en unknown
-
2003
- 2003-06-04 US US10/454,041 patent/US6784298B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1280801A2 (en) | 2003-02-05 |
JP2003531905A (ja) | 2003-10-28 |
CN1427838A (zh) | 2003-07-02 |
UY26689A1 (es) | 2001-11-30 |
US6784298B2 (en) | 2004-08-31 |
AU2001252270B2 (en) | 2005-12-15 |
ATE304011T1 (de) | 2005-09-15 |
MXPA02010746A (es) | 2003-03-10 |
CA2407428C (en) | 2010-02-02 |
KR100505312B1 (ko) | 2005-08-04 |
EP1280801B1 (en) | 2005-09-07 |
DK1280801T3 (da) | 2006-01-23 |
CA2407428A1 (en) | 2001-11-08 |
BR0110492A (pt) | 2003-04-08 |
ES2248309T3 (es) | 2006-03-16 |
PT1280801E (pt) | 2005-11-30 |
JP3842131B2 (ja) | 2006-11-08 |
DE60113247D1 (de) | 2005-10-13 |
US20030225286A1 (en) | 2003-12-04 |
ZA200208370B (en) | 2004-01-26 |
WO2001083478A3 (en) | 2002-05-16 |
US20010056191A1 (en) | 2001-12-27 |
PE20011313A1 (es) | 2001-12-28 |
AR034253A1 (es) | 2004-02-18 |
DE60113247T2 (de) | 2006-06-22 |
WO2001083478A2 (en) | 2001-11-08 |
AU5227001A (en) | 2001-11-12 |
US6583288B2 (en) | 2003-06-24 |
CN1209361C (zh) | 2005-07-06 |
KR20020093120A (ko) | 2002-12-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP014055A (es) | Activadores de glucoquinasa que contienen hidantoina | |
UY26694A1 (es) | Activadores de fenil glucocinasa para - arilo o hetero sustituidos | |
PA8525201A1 (es) | Tetrazolil-fenil acetamidas como activadores de la glucoquinasa | |
ECSP014054A (es) | Activadores de glucoquinasa alquinil fenil heteroaromatica | |
UY28121A1 (es) | Activadores de glucoquinasa heteroaromaticos de seis miembros 5-sustituidos | |
UY27069A1 (es) | Activadores de glucocinasa del tipo isoindolin-1-ona | |
UY28005A1 (es) | Indol -3-carboxamidas como activadores de glucoquinasa (gk) | |
ECSP066549A (es) | Compuestos de pirazolilo e imidazolilo bicíclicos y usos de los mismos | |
PA8600601A1 (es) | Ligandos de receptores de cannabinoides y sus usos | |
UY26695A1 (es) | Activadores para amino sustituidos de la fenilamida glucoquinasa | |
GT200300096A (es) | Activadores de cicloalquil sustituidos y cicloalquil oxigenados de glucoquinasa | |
DOP2006000052A (es) | Alargar el tiempo hasta la progresión de la enfermedad o la supervivencia de los pacientes de cáncer | |
ECSP055535A (es) | Derivados de 1-heterociclialquil-3-sulfonilazaindol o azaindol como ligandos de 5-hidroxitriptamina-6 | |
SV2009003235A (es) | Triazoles biciclicos como moduladores de la proteina cinasa ref. x-18476m | |
ECSP105178A (es) | Compuestos de aril urea en combinación con otros agentes citostáticos o citotóxicos para el tratamiento de cáncer en humanos | |
GT199900070A (es) | Derivados de isotiazol, utiles como agentes anticancerosos. | |
GT200600429A (es) | Compuestos organicos | |
PA8468401A1 (es) | Compuestos para el tratamiento de la isquemia | |
CR6935A (es) | Agentes del receptor b3-adrenergico y usos de los mismos | |
NO20091260L (no) | Kombinasjonsbehandling for diabetes mellitus | |
ECSP067120A (es) | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas | |
UY29478A1 (es) | Compuestos heteroaromaticos acilaminobiciclicos y sus usos | |
CO6382118A2 (es) | Nuevas octahidrociclopenta(c)ciprol-4aminas sustituidas como bloqueantes de los canales de calcio | |
GT200900287A (es) | Extrudidos con enmascaramiento del sabor mejorado | |
PA8532001A1 (es) | Bifenilcarboxamidas utiles como agentes reductores de lipidos |