EA201270217A1 - Замещенные бензамидные производные в качестве активаторов глюкокиназы (гк) - Google Patents

Замещенные бензамидные производные в качестве активаторов глюкокиназы (гк)

Info

Publication number
EA201270217A1
EA201270217A1 EA201270217A EA201270217A EA201270217A1 EA 201270217 A1 EA201270217 A1 EA 201270217A1 EA 201270217 A EA201270217 A EA 201270217A EA 201270217 A EA201270217 A EA 201270217A EA 201270217 A1 EA201270217 A1 EA 201270217A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glucokinase
compounds
benzamide derivatives
substituted benzamide
activators
Prior art date
Application number
EA201270217A
Other languages
English (en)
Inventor
Раджендра Кхарул
Мукул Р. Джаин
Панкадж Р. Пател
Original Assignee
Кадила Хелзкэр Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кадила Хелзкэр Лимитед filed Critical Кадила Хелзкэр Лимитед
Publication of EA201270217A1 publication Critical patent/EA201270217A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Настоящее изобретение относится к замещенным бензамидным производным общей формулы (I) и их фармацевтически приемлемым солям, фармацевтически приемлемым сольватам, энантиомерам, диастереомерам, пролекарствам, метаболитам и полиморфам и может быть полезным для лечения болезненных состояний, опосредованных глюкокиназой. Соединения, раскрытые в настоящей заявке, можно использовать для снижения уровней глюкозы в крови и для увеличения секреции инсулина для лечения сахарного диабета II типа. Изобретение также относится к способам получения соединений по настоящему изобретению, фармацевтических композиций, содержащих такие соединения, и к их применению.
EA201270217A 2009-07-31 2010-07-22 Замещенные бензамидные производные в качестве активаторов глюкокиназы (гк) EA201270217A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1767MU2009 2009-07-31
PCT/IN2010/000486 WO2011013141A2 (en) 2009-07-31 2010-07-22 Substituted benzamide derivatives as glucokinase (gk) activators

Publications (1)

Publication Number Publication Date
EA201270217A1 true EA201270217A1 (ru) 2012-09-28

Family

ID=43432167

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270217A EA201270217A1 (ru) 2009-07-31 2010-07-22 Замещенные бензамидные производные в качестве активаторов глюкокиназы (гк)

Country Status (16)

Country Link
US (1) US8835469B2 (ru)
EP (1) EP2459554B1 (ru)
JP (1) JP2013500961A (ru)
KR (1) KR20120047960A (ru)
CN (1) CN102482267B (ru)
AU (1) AU2010277171B2 (ru)
CA (1) CA2768232A1 (ru)
DK (1) DK2459554T3 (ru)
EA (1) EA201270217A1 (ru)
MX (1) MX2012001228A (ru)
MY (1) MY156175A (ru)
NZ (1) NZ598232A (ru)
SG (1) SG178043A1 (ru)
UA (1) UA103807C2 (ru)
WO (1) WO2011013141A2 (ru)
ZA (1) ZA201200561B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
CN106176776A (zh) * 2016-07-04 2016-12-07 华北制药集团新药研究开发有限责任公司 葡萄糖激酶激动活性化合物的医药用途
GB201714777D0 (en) 2017-09-14 2017-11-01 Univ London Queen Mary Agent

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6353111B1 (en) 1999-12-15 2002-03-05 Hoffmann-La Roche Inc. Trans olefinic glucokinase activators
BR0110492A (pt) 2000-05-03 2003-04-08 Hoffmann La Roche Composto, composição farmacêutica que compreende esse composto, processo para a preparação de composição farmacêutica, utilização do composto e processo para a preparação do composto
WO2002008209A1 (en) 2000-07-20 2002-01-31 F. Hoffmann-La Roche Ag Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
CN100591671C (zh) * 2003-02-26 2010-02-24 万有制药株式会社 杂芳基氨基甲酰基苯衍生物
MXPA05009059A (es) * 2003-02-26 2005-10-19 Banyu Pharma Co Ltd Derivados de heteroarilcarbamoilbenceno.
KR20070007103A (ko) 2004-02-18 2007-01-12 아스트라제네카 아베 벤즈아미드 유도체 및 이의 글루코키나아제 활성화제로서의용도
AU2005214137B2 (en) * 2004-02-18 2008-05-29 Astrazeneca Ab Compounds
TW200600086A (en) 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
GB0423043D0 (en) 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
US20080234273A1 (en) 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
FR2907720B1 (fr) 2006-10-25 2009-12-18 Renault Sas Transmission a derivation de puissance et blocage de l'arbre d'entree de la transmission entraine par le moteur thermique d'un vehicule.

Also Published As

Publication number Publication date
SG178043A1 (en) 2012-03-29
NZ598232A (en) 2013-08-30
MX2012001228A (es) 2012-04-20
DK2459554T3 (da) 2014-01-06
CN102482267B (zh) 2014-12-03
MY156175A (en) 2016-01-15
WO2011013141A2 (en) 2011-02-03
WO2011013141A3 (en) 2011-03-24
AU2010277171A1 (en) 2012-02-09
CN102482267A (zh) 2012-05-30
UA103807C2 (ru) 2013-11-25
US8835469B2 (en) 2014-09-16
EP2459554A2 (en) 2012-06-06
EP2459554B1 (en) 2013-09-18
KR20120047960A (ko) 2012-05-14
US20120184544A1 (en) 2012-07-19
JP2013500961A (ja) 2013-01-10
CA2768232A1 (en) 2011-02-03
ZA201200561B (en) 2012-09-26
AU2010277171B2 (en) 2013-02-07

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