MX2012001228A - Derivados de benzamida sustituidos como activadores de glucocinasa (gk). - Google Patents
Derivados de benzamida sustituidos como activadores de glucocinasa (gk).Info
- Publication number
- MX2012001228A MX2012001228A MX2012001228A MX2012001228A MX2012001228A MX 2012001228 A MX2012001228 A MX 2012001228A MX 2012001228 A MX2012001228 A MX 2012001228A MX 2012001228 A MX2012001228 A MX 2012001228A MX 2012001228 A MX2012001228 A MX 2012001228A
- Authority
- MX
- Mexico
- Prior art keywords
- glucokinase
- compounds
- benzamide derivatives
- substituted benzamide
- activators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con derivados de benzamida sustituidos de Fórmula general I y sus sales farmacéuticamente aceptables, solvatos farmacéuticamente aceptables, enantiómeros, diaestereómeros, profármacos, metabolitos, y polimorfos, y pueden ser útiles para el tratamiento de estados de enfermedad mediados por glucocinasa. Los compuestos descritos aquí se pueden usar para reducir los niveles de glucosa en la sangre y para aumentar la secreción de insulina para tratar diabetes tipo II. La invención también se relaciona con procesos para la preparación de los compuestos de la invención, composiciones farmacéuticas que contienen los compuestos, y su uso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1767MU2009 | 2009-07-31 | ||
PCT/IN2010/000486 WO2011013141A2 (en) | 2009-07-31 | 2010-07-22 | Substituted benzamide derivatives as glucokinase (gk) activators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012001228A true MX2012001228A (es) | 2012-04-20 |
Family
ID=43432167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012001228A MX2012001228A (es) | 2009-07-31 | 2010-07-22 | Derivados de benzamida sustituidos como activadores de glucocinasa (gk). |
Country Status (16)
Country | Link |
---|---|
US (1) | US8835469B2 (es) |
EP (1) | EP2459554B1 (es) |
JP (1) | JP2013500961A (es) |
KR (1) | KR20120047960A (es) |
CN (1) | CN102482267B (es) |
AU (1) | AU2010277171B2 (es) |
CA (1) | CA2768232A1 (es) |
DK (1) | DK2459554T3 (es) |
EA (1) | EA201270217A1 (es) |
MX (1) | MX2012001228A (es) |
MY (1) | MY156175A (es) |
NZ (1) | NZ598232A (es) |
SG (1) | SG178043A1 (es) |
UA (1) | UA103807C2 (es) |
WO (1) | WO2011013141A2 (es) |
ZA (1) | ZA201200561B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
CN106176776A (zh) * | 2016-07-04 | 2016-12-07 | 华北制药集团新药研究开发有限责任公司 | 葡萄糖激酶激动活性化合物的医药用途 |
GB201714777D0 (en) | 2017-09-14 | 2017-11-01 | Univ London Queen Mary | Agent |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6353111B1 (en) | 1999-12-15 | 2002-03-05 | Hoffmann-La Roche Inc. | Trans olefinic glucokinase activators |
AU2001252270B2 (en) | 2000-05-03 | 2005-12-15 | F. Hoffmann-La Roche Ag | Hydantoin-containing glucokinase activators |
DK1305301T3 (da) | 2000-07-20 | 2005-10-17 | Hoffmann La Roche | Alpha-acyl- og alpha-heteroatomsubstituerede benzenacetamidglucokinase-aktivatorer |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
CN100591671C (zh) * | 2003-02-26 | 2010-02-24 | 万有制药株式会社 | 杂芳基氨基甲酰基苯衍生物 |
CN101712657A (zh) | 2003-02-26 | 2010-05-26 | 万有制药株式会社 | 杂芳基氨基甲酰基苯衍生物 |
WO2005080359A1 (en) | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
JP2007523905A (ja) * | 2004-02-18 | 2007-08-23 | アストラゼネカ アクチボラグ | 化合物 |
TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
GB0423043D0 (en) | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
EP2027113A1 (en) | 2005-07-09 | 2009-02-25 | AstraZeneca AB | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
FR2907720B1 (fr) | 2006-10-25 | 2009-12-18 | Renault Sas | Transmission a derivation de puissance et blocage de l'arbre d'entree de la transmission entraine par le moteur thermique d'un vehicule. |
-
2010
- 2010-07-22 AU AU2010277171A patent/AU2010277171B2/en not_active Ceased
- 2010-07-22 KR KR1020127004502A patent/KR20120047960A/ko not_active Application Discontinuation
- 2010-07-22 DK DK10779053.7T patent/DK2459554T3/da active
- 2010-07-22 MY MYPI2012000195A patent/MY156175A/en unknown
- 2010-07-22 CN CN201080038726.4A patent/CN102482267B/zh not_active Expired - Fee Related
- 2010-07-22 JP JP2012522338A patent/JP2013500961A/ja not_active Ceased
- 2010-07-22 SG SG2012003398A patent/SG178043A1/en unknown
- 2010-07-22 CA CA2768232A patent/CA2768232A1/en not_active Abandoned
- 2010-07-22 EA EA201270217A patent/EA201270217A1/ru unknown
- 2010-07-22 US US13/387,885 patent/US8835469B2/en not_active Expired - Fee Related
- 2010-07-22 EP EP10779053.7A patent/EP2459554B1/en not_active Not-in-force
- 2010-07-22 UA UAA201200651A patent/UA103807C2/ru unknown
- 2010-07-22 MX MX2012001228A patent/MX2012001228A/es active IP Right Grant
- 2010-07-22 WO PCT/IN2010/000486 patent/WO2011013141A2/en active Application Filing
- 2010-07-22 NZ NZ598232A patent/NZ598232A/xx not_active IP Right Cessation
-
2012
- 2012-01-24 ZA ZA2012/00561A patent/ZA201200561B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20120184544A1 (en) | 2012-07-19 |
UA103807C2 (ru) | 2013-11-25 |
SG178043A1 (en) | 2012-03-29 |
JP2013500961A (ja) | 2013-01-10 |
WO2011013141A2 (en) | 2011-02-03 |
AU2010277171B2 (en) | 2013-02-07 |
MY156175A (en) | 2016-01-15 |
EP2459554A2 (en) | 2012-06-06 |
ZA201200561B (en) | 2012-09-26 |
EA201270217A1 (ru) | 2012-09-28 |
NZ598232A (en) | 2013-08-30 |
US8835469B2 (en) | 2014-09-16 |
AU2010277171A1 (en) | 2012-02-09 |
KR20120047960A (ko) | 2012-05-14 |
CN102482267A (zh) | 2012-05-30 |
EP2459554B1 (en) | 2013-09-18 |
WO2011013141A3 (en) | 2011-03-24 |
CN102482267B (zh) | 2014-12-03 |
CA2768232A1 (en) | 2011-02-03 |
DK2459554T3 (da) | 2014-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |