WO2011070592A3 - Novel sugar derivatives as sglt2 inhibitors - Google Patents

Novel sugar derivatives as sglt2 inhibitors Download PDF

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Publication number
WO2011070592A3
WO2011070592A3 PCT/IN2010/000796 IN2010000796W WO2011070592A3 WO 2011070592 A3 WO2011070592 A3 WO 2011070592A3 IN 2010000796 W IN2010000796 W IN 2010000796W WO 2011070592 A3 WO2011070592 A3 WO 2011070592A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
polymorphs
prodrugs
solvates
metabolites
Prior art date
Application number
PCT/IN2010/000796
Other languages
French (fr)
Other versions
WO2011070592A2 (en
Inventor
Rajesh Jain
Sanjay Trehan
Sastry V.R.S. Thungathurthi
Gurmeet Kaur Nanda
Jagattaran Das
Sitaram Kumar Magadi
Sudhir Kumar Sharma
Original Assignee
Panacea Biotec Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd. filed Critical Panacea Biotec Ltd.
Publication of WO2011070592A2 publication Critical patent/WO2011070592A2/en
Publication of WO2011070592A3 publication Critical patent/WO2011070592A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Abstract

The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2). The invention also relates to the use of compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof, for the manufacture of a medicament for the prophylaxis, amelioration and/or treatment of conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2) and the related diseases, disorders and conditions, in a subject in need thereof.
PCT/IN2010/000796 2009-12-09 2010-12-09 Novel sugar derivatives WO2011070592A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2553DE2009 2009-12-09
IN2553/DEL/2009 2009-12-09

Publications (2)

Publication Number Publication Date
WO2011070592A2 WO2011070592A2 (en) 2011-06-16
WO2011070592A3 true WO2011070592A3 (en) 2012-05-10

Family

ID=44145994

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000796 WO2011070592A2 (en) 2009-12-09 2010-12-09 Novel sugar derivatives

Country Status (2)

Country Link
AR (1) AR079438A1 (en)
WO (1) WO2011070592A2 (en)

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WO2013038429A2 (en) 2011-09-13 2013-03-21 Panacea Biotec Ltd. Novel sglt inhibitors
TW201335176A (en) 2011-12-15 2013-09-01 Nat Health Research Institutes Novel glycoside compounds
US9085517B2 (en) 2011-12-15 2015-07-21 Pfizer Limited Sulfonamide derivatives
DK2925735T3 (en) 2012-11-20 2019-06-17 Lexicon Pharmaceuticals Inc Inhibitors of sodium glucose co-transporter 1
US20220242898A1 (en) * 2019-07-26 2022-08-04 Medshine Discovery Inc. Sglt2/dpp4 inhibitor and application thereof
WO2022160737A1 (en) * 2021-01-26 2022-08-04 东宝紫星(杭州)生物医药有限公司 Crystal form of tetrahydropyran ring compound and preparation method therefor

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027128A1 (en) * 1999-10-12 2001-04-19 Bristol-Myers Squibb Company C-aryl glucoside sglt2 inhibitors
WO2009026537A1 (en) * 2007-08-23 2009-02-26 Theracos, Inc. Benzylbenzene derivatives and methods of use

Also Published As

Publication number Publication date
WO2011070592A2 (en) 2011-06-16
AR079438A1 (en) 2012-01-25

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