ES2196072T3 - Empleo de compuestos heterociclicos como ligandos de dopamina-d3. - Google Patents

Empleo de compuestos heterociclicos como ligandos de dopamina-d3.

Info

Publication number
ES2196072T3
ES2196072T3 ES95926896T ES95926896T ES2196072T3 ES 2196072 T3 ES2196072 T3 ES 2196072T3 ES 95926896 T ES95926896 T ES 95926896T ES 95926896 T ES95926896 T ES 95926896T ES 2196072 T3 ES2196072 T3 ES 2196072T3
Authority
ES
Spain
Prior art keywords
legandos
dopamina
employment
compounds
heterociclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95926896T
Other languages
English (en)
Inventor
Beate Hellendahl
Annegret Lansky
Beatrice Rendenbach-Muller
Alfred Bach
Liliane Unger
Hans-Jurgen Teschendorf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Abbott GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG
Application granted granted Critical
Publication of ES2196072T3 publication Critical patent/ES2196072T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

LA PRESENTE INVENCION TRATA DE LA UTILIZACION DE COMPUESTOS HETEROCICLICOS DE FORMULA (I) HET - A - B - AR, EN DONDE HET, A, B Y AR TIENEN LOS SIGNIFICADOS DADOS EN LA DESCRIPCION. LOS COMPUESTOS DE LA INVENCION POSEEN UNA ELEVADA AFINIDAD POR EL RECEPTOR D3 DE LA DOPAMINA Y SON UTILES POR TANTO PARA EL TRATAMIENTO DE ENFERMEDADES QUE TENGAN QUE VER CON LIGANDOS D3 DE LA DOPAMINA.
ES95926896T 1994-07-15 1995-07-14 Empleo de compuestos heterociclicos como ligandos de dopamina-d3. Expired - Lifetime ES2196072T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4425146A DE4425146A1 (de) 1994-07-15 1994-07-15 Verwendung heterocyclischer Verbindungen

Publications (1)

Publication Number Publication Date
ES2196072T3 true ES2196072T3 (es) 2003-12-16

Family

ID=6523325

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95926896T Expired - Lifetime ES2196072T3 (es) 1994-07-15 1995-07-14 Empleo de compuestos heterociclicos como ligandos de dopamina-d3.

Country Status (22)

Country Link
US (1) US6090807A (es)
EP (1) EP0771197B1 (es)
JP (1) JPH10502658A (es)
KR (2) KR970704435A (es)
CN (2) CN1152870A (es)
AT (1) ATE236629T1 (es)
AU (1) AU704839B2 (es)
BG (1) BG63487B1 (es)
BR (1) BR9508296A (es)
CA (1) CA2195242A1 (es)
CZ (1) CZ293126B6 (es)
DE (2) DE4425146A1 (es)
DK (1) DK0771197T3 (es)
ES (1) ES2196072T3 (es)
FI (1) FI970148A7 (es)
HU (1) HUT77608A (es)
MX (1) MX9700430A (es)
NO (1) NO311683B1 (es)
NZ (1) NZ290388A (es)
PT (1) PT771197E (es)
SI (1) SI9520084B (es)
WO (1) WO1996002246A1 (es)

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DE19600934A1 (de) 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
TR199802284T2 (xx) * 1996-05-11 2000-05-22 Smithkline Beecham P.L.C. Dopamin D3 resept�rlerinin mod�lat�rleri olarak tetrahidroizokuinolin t�revleri.
AU4204697A (en) * 1996-08-14 1998-03-06 Smithkline Beecham Plc Tetrahydroisoquinoline derivatives and their pharmaceutical use
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GB9708805D0 (en) * 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9709303D0 (en) * 1997-05-09 1997-06-25 Smithkline Beecham Plc Compounds
DE19728996A1 (de) * 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
TW530054B (en) 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
US6218396B1 (en) * 1998-02-20 2001-04-17 Orth-Mcneil Pharmaceutical, Inc. Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
IL142388A0 (en) 1998-10-08 2002-03-10 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
EP1027885B1 (en) 1999-02-09 2008-07-09 Pfizer Products Inc. Basic drug compositions with enhanced bioavailability
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
US6365591B1 (en) 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
IT1314191B1 (it) * 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
EP1272187B1 (de) * 2000-03-27 2008-07-30 Abbott GmbH & Co. KG Dopamin-d3-rezeptor-liganden zur behandlung von sucht
GB0025354D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
GB0117577D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
GB0108594D0 (en) * 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
WO2003066589A1 (en) * 2002-02-08 2003-08-14 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
GB0203020D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203022D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
US20050197343A1 (en) * 2002-07-04 2005-09-08 Peter Gmeiner Utilization of heteroarene carboxamide as dopamine-d3 ligands for the treatment of cns diseases
DE10232020A1 (de) * 2002-07-04 2004-02-26 Friedrich-Alexander-Universität Erlangen-Nürnberg Neurorezeptoraktive Heteroarencarboxamide
TW200507841A (en) * 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
DE10315569A1 (de) * 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazolverbindungen
US7320979B2 (en) * 2003-04-14 2008-01-22 Abbott Gmbh & Co. Kg. N-[(piperazinyl)hetaryl]arylsulfonamide compounds
US20040204422A1 (en) * 2003-04-14 2004-10-14 Abbott Gmbh & Co. Kg. N-[(Piperazinyl)hetaryl]arylsulfonamide compounds
DE10358004A1 (de) 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam-Verbindungen und ihre Verwendung
US20050137186A1 (en) 2003-12-18 2005-06-23 Abbott Gmbh & Co. Kg. Tetrahydrobenzazepines and their use
ATE529114T1 (de) 2003-12-18 2011-11-15 Abbott Gmbh & Co Kg Tetrahydrobenzazepine und ihre verwendung in der modulation des dopamin-d3-rezeptors
DE102004027359A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyridin-2-onverbindungen und deren Verwendung
DE102004027358A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
JP4904267B2 (ja) 2004-08-09 2012-03-28 アボット ゲーエムベーハー ウント カンパニー カーゲー ドーパミンｄ３受容体の調節に応答する障害の治療に好適な４−ピペラジニル−ピリミジン化合物
US20090238761A1 (en) * 2005-01-03 2009-09-24 Universita Degli Studi Di Siena Novel Aryl Piperazine Derivatives With Medical Utility
EP1846411A4 (en) * 2005-01-25 2010-08-04 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
PA8802101A1 (es) 2007-11-02 2009-08-26 Abbott Gmbh & Co Kg Compuestos de 1,2,4-3,5-diona adecuados para el tratamiento de trastornos que responden a la modulación del receptor de dopamina d3
US20110059019A1 (en) * 2008-02-01 2011-03-10 Neurosearch A/S Novel aryl piperazine derivatives useful as modulators of dopamine and serotonin receptors
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
US8829001B2 (en) 2008-10-10 2014-09-09 The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
ES2540232T3 (es) 2009-07-08 2015-07-09 Dermira (Canada), Inc. Análogos de TOFA útiles en el tratamiento de trastornos o afecciones dermatológicas
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
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MX2024009077A (es) 2022-01-29 2024-09-30 Suven Life Sciences Ltd Compuestos de benzotiazol y benzoisoxazola para el tratamiento de trastornos mentales.

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Also Published As

Publication number Publication date
DE4425146A1 (de) 1996-01-18
NO311683B1 (no) 2002-01-07
FI970148A0 (fi) 1997-01-14
HUT77608A (hu) 1998-06-29
DE59510635D1 (de) 2003-05-15
CZ293126B6 (cs) 2004-02-18
CN1152870A (zh) 1997-06-25
MX9700430A (es) 1998-05-31
NZ290388A (en) 2001-04-27
CA2195242A1 (en) 1996-02-01
CZ9697A3 (en) 1997-08-13
BG63487B1 (bg) 2002-03-29
EP0771197A1 (de) 1997-05-07
AU704839B2 (en) 1999-05-06
DK0771197T3 (da) 2003-06-23
KR100443850B1 (ko) 2004-08-11
HU9700111D0 (en) 1997-02-28
NO970163L (no) 1997-03-14
EP0771197B1 (de) 2003-04-09
NO970163D0 (no) 1997-01-14
KR20040000412A (ko) 2004-01-03
BR9508296A (pt) 1998-05-19
CN1534023A (zh) 2004-10-06
SI9520084B (sl) 2005-02-28
FI970148L (fi) 1997-01-14
WO1996002246A1 (de) 1996-02-01
SI9520084A (en) 1997-08-31
AU3111495A (en) 1996-02-16
JPH10502658A (ja) 1998-03-10
FI970148A7 (fi) 1997-01-14
KR970704435A (ko) 1997-09-06
PT771197E (pt) 2003-08-29
US6090807A (en) 2000-07-18
ATE236629T1 (de) 2003-04-15
BG101112A (bg) 1998-04-30

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