CO4560552A1 - Antagonistas de receptores de taquicininas no peptidicos - Google Patents
Antagonistas de receptores de taquicininas no peptidicosInfo
- Publication number
- CO4560552A1 CO4560552A1 CO95017350A CO95017350A CO4560552A1 CO 4560552 A1 CO4560552 A1 CO 4560552A1 CO 95017350 A CO95017350 A CO 95017350A CO 95017350 A CO95017350 A CO 95017350A CO 4560552 A1 CO4560552 A1 CO 4560552A1
- Authority
- CO
- Colombia
- Prior art keywords
- antagonists
- recipient
- tachycin
- peptidic
- substituted
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000003141 Tachykinin Human genes 0.000 abstract 1
- 150000001556 benzimidazoles Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 108060008037 tachykinin Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
ESTA INVENCION PROPORCIONA NUEVOS BENCIMIDAZOLES SUSTITUIDOS QUE SON UTILES COMO ANTAGONISTAS DE RECEPTORES DE TAQUIKININAS. ESTAS INVENCION PROPORCIONA TAMBIEN METODOS PARA SOMETER A TRATAMIENTO UN ESTADO ASOCIADO CON UN EXCESO DE TAQUIKININA, QUE COMPRENDE ADMINISTRAR A UN MAMIFERO QUE NECESITA EL MISMO UNO DE UNA SERIE DE BENCIMIDAZOLES SUSTITUIDOS. ESTA INVENCION PROPORCIONA ADICIONALMENTE FORMULACIONES FARMACEUTICAS QUE COMPRENDEN UNO O MAS DE LOS BENCIMIDAZOLES SUSTITUIDOS DE LA PRESENTE INVENCION EN ASOCIACION CON VEHICULOS, DILUYENTES O EXCIPIENTES FARMACEUTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23540194A | 1994-04-29 | 1994-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4560552A1 true CO4560552A1 (es) | 1998-02-10 |
Family
ID=22885338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO95017350A CO4560552A1 (es) | 1994-04-29 | 1995-04-26 | Antagonistas de receptores de taquicininas no peptidicos |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0694535A1 (es) |
JP (1) | JPH08109169A (es) |
KR (1) | KR950031074A (es) |
CN (1) | CN1113236A (es) |
AU (1) | AU1765695A (es) |
BR (1) | BR9501770A (es) |
CA (1) | CA2148053A1 (es) |
CO (1) | CO4560552A1 (es) |
CZ (1) | CZ104795A3 (es) |
FI (1) | FI952064A (es) |
HU (1) | HUT70637A (es) |
IL (1) | IL113472A0 (es) |
NO (1) | NO951613L (es) |
NZ (1) | NZ270985A (es) |
PE (1) | PE27997A1 (es) |
PL (1) | PL308334A1 (es) |
RU (1) | RU95106649A (es) |
ZA (1) | ZA953311B (es) |
Families Citing this family (73)
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AU5966096A (en) * | 1995-06-09 | 1997-01-09 | Eli Lilly And Company | Methods of treating cold and allergic rhinitis |
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JP3271991B2 (ja) | 1997-11-07 | 2002-04-08 | 大鵬薬品工業株式会社 | ベンズイミダゾール誘導体及びその薬学的に許容される塩 |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
BR0015320A (pt) | 1999-11-03 | 2002-07-09 | Albany Molecular Res Inc | Composto, composição, métodos de tratamento de um distúrbio que e criado pela, ou é dependente da, disponibilidade diminuìda de serotonina, norepinefrina ou dopamina, para inibir a captação da serotonina, da dopamina e de norepinefrina sinápticas em um paciente em necessidade destes, e, kit |
US6770666B2 (en) | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
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CZ303726B6 (cs) * | 2000-01-14 | 2013-04-10 | Bayer Intellectual Property Gmbh | Benzimidazolové deriváty, farmaceutický prostredek obsahující tyto deriváty a pouzití techto derivátu pro prípravu léciv |
US7115645B2 (en) * | 2000-01-14 | 2006-10-03 | Schering Aktiengesellschaft | 1,2 diarylbenzimidazoles and their pharmaceutical use |
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CN102448458B (zh) | 2009-03-18 | 2015-07-22 | 小利兰·斯坦福大学理事会 | 治疗黄病毒科病毒感染的方法和组合物 |
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CN105837522A (zh) * | 2016-06-14 | 2016-08-10 | 绍兴文理学院 | 一种1,5-苯并二氮卓酮衍生物的制备方法 |
GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
CN110536890B (zh) | 2017-04-26 | 2023-08-15 | 巴斯利尔药物国际股份公司 | 制备呋咱并苯并咪唑及其晶型的方法 |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
US11993602B2 (en) | 2018-08-07 | 2024-05-28 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
CN111004183B (zh) * | 2019-12-27 | 2022-04-22 | 阜阳欣奕华材料科技有限公司 | 一种有机电致发光化合物、电子传输材料和有机电致发光器件 |
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Publication number | Priority date | Publication date | Assignee | Title |
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GB1174493A (en) * | 1967-05-10 | 1969-12-17 | Manufactures J R Bottu | New Benzimidazoles and process for their preparation |
JPS50126682A (es) | 1974-03-25 | 1975-10-04 | ||
US4200641A (en) | 1976-12-21 | 1980-04-29 | Janssen Pharmaceutica, N.V. | 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives |
EP0178413A1 (en) | 1984-08-17 | 1986-04-23 | Beecham Group Plc | Benzimidazoles |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
FR2597478B1 (fr) | 1986-04-21 | 1988-12-16 | Esteve Labor Dr | Benzimidazoles et imidazopyridines sulfonamides, leur preparation et leur application en tant que medicaments. |
DE3728695A1 (de) | 1987-08-25 | 1989-03-09 | Schering Ag | Neue benzimidazol-derivate |
DE3800096A1 (de) | 1988-01-05 | 1989-07-13 | Bayer Ag | Verwendung von benzimidazolderivaten als leistungsfoerderer |
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
JPH0772181B2 (ja) * | 1989-06-26 | 1995-08-02 | 株式会社大塚製薬工場 | ベンズイミダゾール誘導体 |
FR2665161B1 (fr) | 1990-07-26 | 1992-11-27 | Esteve Labor Dr | Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments. |
WO1994004494A1 (en) | 1992-08-13 | 1994-03-03 | Warner-Lambert Company | Tachykinin antagonists |
US5472978A (en) | 1991-07-05 | 1995-12-05 | Merck Sharp & Dohme Ltd. | Aromatic compounds, pharmaceutical compositions containing them and their use in therapy |
US5612336A (en) | 1992-07-13 | 1997-03-18 | Merck, Sharp & Dohme Ltd. | Heterocyclic amide derivatives as tachykinin antagonists |
FR2696178B1 (fr) | 1992-09-30 | 1994-12-30 | Sanofi Elf | Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant. |
-
1995
- 1995-04-24 IL IL11347295A patent/IL113472A0/xx unknown
- 1995-04-24 CZ CZ951047A patent/CZ104795A3/cs unknown
- 1995-04-24 NZ NZ270985A patent/NZ270985A/en unknown
- 1995-04-24 ZA ZA953311A patent/ZA953311B/xx unknown
- 1995-04-24 PE PE1995266991A patent/PE27997A1/es not_active Application Discontinuation
- 1995-04-24 EP EP95302707A patent/EP0694535A1/en not_active Withdrawn
- 1995-04-25 PL PL95308334A patent/PL308334A1/xx unknown
- 1995-04-25 BR BR9501770A patent/BR9501770A/pt not_active Application Discontinuation
- 1995-04-26 CO CO95017350A patent/CO4560552A1/es unknown
- 1995-04-26 AU AU17656/95A patent/AU1765695A/en not_active Abandoned
- 1995-04-26 CN CN95104725A patent/CN1113236A/zh active Pending
- 1995-04-27 CA CA002148053A patent/CA2148053A1/en not_active Abandoned
- 1995-04-27 KR KR1019950010020A patent/KR950031074A/ko not_active Application Discontinuation
- 1995-04-27 RU RU95106649/04A patent/RU95106649A/ru unknown
- 1995-04-27 NO NO951613A patent/NO951613L/no unknown
- 1995-04-28 JP JP7105297A patent/JPH08109169A/ja not_active Withdrawn
- 1995-04-28 HU HU9501249A patent/HUT70637A/hu unknown
- 1995-04-28 FI FI952064A patent/FI952064A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
RU95106649A (ru) | 1997-01-10 |
BR9501770A (pt) | 1995-11-21 |
JPH08109169A (ja) | 1996-04-30 |
HUT70637A (en) | 1995-10-30 |
PL308334A1 (en) | 1995-10-30 |
KR950031074A (ko) | 1995-12-18 |
CA2148053A1 (en) | 1995-10-30 |
NZ270985A (en) | 1997-06-24 |
IL113472A0 (en) | 1995-07-31 |
NO951613D0 (no) | 1995-04-27 |
FI952064A0 (fi) | 1995-04-28 |
FI952064A (fi) | 1995-10-30 |
CN1113236A (zh) | 1995-12-13 |
ZA953311B (en) | 1996-10-24 |
NO951613L (no) | 1995-10-30 |
AU1765695A (en) | 1995-11-09 |
HU9501249D0 (en) | 1995-06-28 |
PE27997A1 (es) | 1997-09-20 |
CZ104795A3 (en) | 1996-02-14 |
EP0694535A1 (en) | 1996-01-31 |
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