DOP2002000545A - Moléculas pequeñas para el tratamiento del crecimiento celular anormal - Google Patents
Moléculas pequeñas para el tratamiento del crecimiento celular anormalInfo
- Publication number
- DOP2002000545A DOP2002000545A DO2002000545A DO2002000545A DOP2002000545A DO P2002000545 A DOP2002000545 A DO P2002000545A DO 2002000545 A DO2002000545 A DO 2002000545A DO 2002000545 A DO2002000545 A DO 2002000545A DO P2002000545 A DOP2002000545 A DO P2002000545A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- small molecules
- treatment
- cell growth
- abnormal cell
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Esta invención se refiere a moleculas pequenas que son utiles en el tratamiento del crecimiento celular anormal, tal como el cancer, en mamiferos. Esta invencion tambien se refiere a un procedimiento de use de tales moleculas pequenas en el tratamiento del crecimiento celular anormal en mamiferos, especialmente en seres humanos, y a composiciones farmaceuticas que contienen tales compuestos. La invencion se refiere ademas a pequenas moleculas que son selectivas pars el receptor. erbB2 respecto al receptor erbBl, teniendo dicho inhibidor de erbB2 un intervalo de selectividades por erbB2 respecto a erbBl entre 50-1500.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34109101P | 2001-12-12 | 2001-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2002000545A true DOP2002000545A (es) | 2003-06-16 |
Family
ID=23336198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2002000545A DOP2002000545A (es) | 2001-12-12 | 2002-12-10 | Moléculas pequeñas para el tratamiento del crecimiento celular anormal |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20030171386A1 (es) |
| EP (1) | EP1465632A1 (es) |
| JP (1) | JP4181502B2 (es) |
| KR (1) | KR20040063948A (es) |
| CN (1) | CN1602195A (es) |
| AP (1) | AP2004003058A0 (es) |
| AR (1) | AR037771A1 (es) |
| AU (1) | AU2002339687A1 (es) |
| BR (1) | BR0214499A (es) |
| CA (1) | CA2469670A1 (es) |
| DO (1) | DOP2002000545A (es) |
| EA (1) | EA200400680A1 (es) |
| EC (1) | ECSP045146A (es) |
| GT (1) | GT200200273A (es) |
| HR (1) | HRP20040529A2 (es) |
| HU (1) | HUP0501069A2 (es) |
| IL (1) | IL161908A0 (es) |
| IS (1) | IS7233A (es) |
| MA (1) | MA27154A1 (es) |
| MX (1) | MXPA04004107A (es) |
| NO (1) | NO20042882L (es) |
| OA (1) | OA12734A (es) |
| PA (1) | PA8561301A1 (es) |
| PE (1) | PE20030760A1 (es) |
| PL (1) | PL373848A1 (es) |
| TN (1) | TNSN04111A1 (es) |
| TW (1) | TW200301121A (es) |
| WO (1) | WO2003049740A1 (es) |
| ZA (1) | ZA200404264B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| CA2491191C (en) | 2002-07-15 | 2014-02-04 | Exelixis, Inc. | Receptor-type kinase modulators and methods of use |
| CN1729001A (zh) * | 2002-12-18 | 2006-02-01 | 辉瑞产品公司 | 用于治疗异常细胞生长的4－苯胺基喹唑啉衍生物 |
| RU2005122659A (ru) * | 2002-12-19 | 2006-01-20 | Пфайзер Продактс Инк. (Us) | Комплексы е-2-метокси-n-(3-{4-[3-метил-4-(6-метилпиридин-3-илокси) фениламино] хиназолин-6-ил} аллил) ацетамида, способ получения и применения указанных комплексов |
| RU2328287C2 (ru) * | 2003-08-18 | 2008-07-10 | Пфайзер Продактс Инк. | Схема приема erbb2 противоопухолевых агентов |
| ES2925655T3 (es) | 2003-09-26 | 2022-10-19 | Exelixis Inc | Moduladores c-Met y métodos de uso |
| RU2006122519A (ru) * | 2003-12-24 | 2008-01-27 | Сайос, Инк. (Us) | Лечение злокачественных глиом ингибиторами тфр-бэта |
| PT1746999E (pt) * | 2004-05-06 | 2012-01-11 | Warner Lambert Co | 4-fenilamino-quinazolin-6-il-amidas |
| GB0417107D0 (en) * | 2004-07-30 | 2004-09-01 | Wellcome Trust The | Genes II |
| EP1896451A2 (en) * | 2005-06-03 | 2008-03-12 | Pfizer Products Incorporated | Bicyclic derivatives for the treatment of abnormal cell growth |
| EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| BRPI0720169A2 (pt) | 2006-12-12 | 2013-12-24 | Takeda Pharmaceutical | Composto ou um sal do mesmo, prodroga, agente farmacêutico, método para a profilaxia ou tratamento de câncer, e, uso do composto |
| JP5377332B2 (ja) | 2007-02-06 | 2013-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式へテロ環、それらの化合物を含む薬剤、その使用及びその製法 |
| EA019709B1 (ru) | 2008-02-07 | 2014-05-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Спирогетероциклы и их применение в качестве лекарственных средств |
| WO2009113560A1 (ja) | 2008-03-12 | 2009-09-17 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| CA2723989C (en) | 2008-05-13 | 2017-04-25 | Astrazeneca Ab | Fumarate salt of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(n-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline |
| CA2733153C (en) | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
| TWI447108B (zh) | 2009-01-16 | 2014-08-01 | Exelixis Inc | Ｎ－（４－｛〔６，７雙（甲氧基）喹啉－４－基〕氧基｝苯基）－ｎ’－（４－氟苯基）環丙烷－１，１－二甲醯胺之蘋果酸鹽及其結晶型 |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| WO2011153049A1 (en) | 2010-06-02 | 2011-12-08 | The Trustees Of The University Of Pennsylvania | Methods and use of compounds that bind to her2/neu receptor complex |
| WO2011153050A1 (en) | 2010-06-02 | 2011-12-08 | The Trustees Of The University Of Pennsylvania | Methods and use of compounds that bind to her2/neu receptor complex |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| MX2014002436A (es) | 2011-08-31 | 2014-05-27 | Genentech Inc | Marcadores de diagnostico. |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| KR101589632B1 (ko) | 2014-06-03 | 2016-02-01 | 한국과학기술연구원 | 항암활성을 가지는 6-벤질옥시퀴나졸린-7-일유레아 유도체 |
| WO2017003668A1 (en) | 2015-07-01 | 2017-01-05 | California Institute Of Technology | Cationic mucic acid polymer-based delivery systems |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US20230126204A1 (en) | 2020-02-03 | 2023-04-27 | Boehringer Ingelheim International Gmbh | [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS |
| JP2023512175A (ja) | 2020-02-03 | 2023-03-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ＨＥＲ２阻害薬としての［１，３］ジアジノ［５，４－ｄ］ピリミジン |
| CN113429390B (zh) * | 2020-03-23 | 2022-04-15 | 苏州恩华生物医药科技有限公司 | 喹唑啉衍生物及其应用 |
| US11608343B2 (en) * | 2020-04-24 | 2023-03-21 | Boehringer Ingelheim International Gmbh | Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5654307A (en) * | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| JP3270834B2 (ja) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
| UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| DE60037020T2 (de) * | 1999-07-09 | 2008-08-21 | Glaxo Group Ltd., Greenford | Anilinochinazoline als protein-tyrosin-kinasehemmer |
| CA2387351C (en) * | 1999-10-19 | 2009-09-08 | Merck & Co., Inc. | Indole derivatives as tyrosine kinase inhibitors |
| AP2001002192A0 (en) * | 2000-06-22 | 2002-12-21 | Pfizer Prod Inc | Substituted bicyclic derivatives for the treatment of abnormal cell growth. |
| IL161915A0 (en) * | 2001-12-12 | 2005-11-20 | Pfizer Prod Inc | Salt forms of methoxy-N-(3-(4-(3-methyl-pyridin-3-yloxyl)-phenylamino)- quinazolin-6-yl)-allyl)-acetamide, its prepar |
-
2002
- 2002-11-04 CN CNA028237293A patent/CN1602195A/zh active Pending
- 2002-11-04 OA OA1200400160A patent/OA12734A/en unknown
- 2002-11-04 CA CA002469670A patent/CA2469670A1/en not_active Abandoned
- 2002-11-04 IL IL16190802A patent/IL161908A0/xx unknown
- 2002-11-04 EP EP02777736A patent/EP1465632A1/en not_active Withdrawn
- 2002-11-04 WO PCT/IB2002/004636 patent/WO2003049740A1/en active Application Filing
- 2002-11-04 BR BR0214499-9A patent/BR0214499A/pt not_active IP Right Cessation
- 2002-11-04 AU AU2002339687A patent/AU2002339687A1/en not_active Abandoned
- 2002-11-04 EA EA200400680A patent/EA200400680A1/ru unknown
- 2002-11-04 HU HU0501069A patent/HUP0501069A2/hu unknown
- 2002-11-04 AP APAP/P/2004/003058A patent/AP2004003058A0/en unknown
- 2002-11-04 MX MXPA04004107A patent/MXPA04004107A/es not_active Application Discontinuation
- 2002-11-04 KR KR10-2004-7009022A patent/KR20040063948A/ko not_active Application Discontinuation
- 2002-11-04 JP JP2003550789A patent/JP4181502B2/ja not_active Expired - Fee Related
- 2002-11-04 PL PL02373848A patent/PL373848A1/xx not_active Application Discontinuation
- 2002-12-10 US US10/315,863 patent/US20030171386A1/en not_active Abandoned
- 2002-12-10 AR ARP020104778A patent/AR037771A1/es unknown
- 2002-12-10 TW TW091135662A patent/TW200301121A/zh unknown
- 2002-12-10 PE PE2002001190A patent/PE20030760A1/es not_active Application Discontinuation
- 2002-12-10 DO DO2002000545A patent/DOP2002000545A/es unknown
- 2002-12-12 GT GT200200273A patent/GT200200273A/es unknown
- 2002-12-12 PA PA20028561301A patent/PA8561301A1/es unknown
-
2004
- 2004-04-26 IS IS7233A patent/IS7233A/is unknown
- 2004-05-31 ZA ZA200404264A patent/ZA200404264B/en unknown
- 2004-06-08 MA MA27731A patent/MA27154A1/fr unknown
- 2004-06-09 HR HR20040529A patent/HRP20040529A2/hr not_active Application Discontinuation
- 2004-06-10 EC EC2004005146A patent/ECSP045146A/es unknown
- 2004-06-11 TN TNP2004000111A patent/TNSN04111A1/fr unknown
- 2004-07-07 NO NO20042882A patent/NO20042882L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20030171386A1 (en) | 2003-09-11 |
| JP2005527486A (ja) | 2005-09-15 |
| JP4181502B2 (ja) | 2008-11-19 |
| IS7233A (is) | 2004-04-26 |
| CN1602195A (zh) | 2005-03-30 |
| AP2004003058A0 (en) | 2004-06-30 |
| BR0214499A (pt) | 2005-05-10 |
| ECSP045146A (es) | 2004-07-23 |
| OA12734A (en) | 2006-06-28 |
| HUP0501069A2 (en) | 2006-06-28 |
| GT200200273A (es) | 2003-10-03 |
| PL373848A1 (en) | 2005-09-19 |
| TW200301121A (en) | 2003-07-01 |
| ZA200404264B (en) | 2005-08-31 |
| IL161908A0 (en) | 2005-11-20 |
| AU2002339687A1 (en) | 2003-06-23 |
| PA8561301A1 (es) | 2003-12-30 |
| TNSN04111A1 (fr) | 2006-06-01 |
| MXPA04004107A (es) | 2004-07-23 |
| CA2469670A1 (en) | 2003-06-19 |
| AR037771A1 (es) | 2004-12-01 |
| MA27154A1 (fr) | 2005-01-03 |
| NO20042882L (no) | 2004-07-07 |
| KR20040063948A (ko) | 2004-07-14 |
| EP1465632A1 (en) | 2004-10-13 |
| PE20030760A1 (es) | 2003-09-05 |
| EA200400680A1 (ru) | 2005-06-30 |
| WO2003049740A1 (en) | 2003-06-19 |
| HRP20040529A2 (en) | 2004-10-31 |
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