ZA200404264B - Quinazoline derivatives for the treatment of abnormal cell growth. - Google Patents
Quinazoline derivatives for the treatment of abnormal cell growth. Download PDFInfo
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- ZA200404264B ZA200404264B ZA200404264A ZA200404264A ZA200404264B ZA 200404264 B ZA200404264 B ZA 200404264B ZA 200404264 A ZA200404264 A ZA 200404264A ZA 200404264 A ZA200404264 A ZA 200404264A ZA 200404264 B ZA200404264 B ZA 200404264B
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- South Africa
- Prior art keywords
- cancer
- erbb2
- methyl
- mammal
- inhibitor
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34109101P | 2001-12-12 | 2001-12-12 |
Publications (1)
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ZA200404264B true ZA200404264B (en) | 2005-08-31 |
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Application Number | Title | Priority Date | Filing Date |
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ZA200404264A ZA200404264B (en) | 2001-12-12 | 2004-05-31 | Quinazoline derivatives for the treatment of abnormal cell growth. |
Country Status (29)
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US (1) | US20030171386A1 (es) |
EP (1) | EP1465632A1 (es) |
JP (1) | JP4181502B2 (es) |
KR (1) | KR20040063948A (es) |
CN (1) | CN1602195A (es) |
AP (1) | AP2004003058A0 (es) |
AR (1) | AR037771A1 (es) |
AU (1) | AU2002339687A1 (es) |
BR (1) | BR0214499A (es) |
CA (1) | CA2469670A1 (es) |
DO (1) | DOP2002000545A (es) |
EA (1) | EA200400680A1 (es) |
EC (1) | ECSP045146A (es) |
GT (1) | GT200200273A (es) |
HR (1) | HRP20040529A2 (es) |
HU (1) | HUP0501069A2 (es) |
IL (1) | IL161908A0 (es) |
IS (1) | IS7233A (es) |
MA (1) | MA27154A1 (es) |
MX (1) | MXPA04004107A (es) |
NO (1) | NO20042882L (es) |
OA (1) | OA12734A (es) |
PA (1) | PA8561301A1 (es) |
PE (1) | PE20030760A1 (es) |
PL (1) | PL373848A1 (es) |
TN (1) | TNSN04111A1 (es) |
TW (1) | TW200301121A (es) |
WO (1) | WO2003049740A1 (es) |
ZA (1) | ZA200404264B (es) |
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RU2005119172A (ru) * | 2002-12-18 | 2006-01-20 | Пфайзер Продактс Инк. (Us) | Производные 4-анилинхиназолина для лечения патологического роста клеток |
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RU2328287C2 (ru) * | 2003-08-18 | 2008-07-10 | Пфайзер Продактс Инк. | Схема приема erbb2 противоопухолевых агентов |
JP4638436B2 (ja) | 2003-09-26 | 2011-02-23 | エグゼリクシス, インコーポレイテッド | c−Metモジュレーターおよびその使用 |
US20050245508A1 (en) * | 2003-12-24 | 2005-11-03 | Scios, Inc. | Treatment of malignant gliomas with TGF-beta inhibitors |
CA2565812C (en) * | 2004-05-06 | 2012-03-13 | Warner-Lambert Company Llc | 4-phenylamino-quinazolin-6-yl-amides |
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JP2008542356A (ja) * | 2005-06-03 | 2008-11-27 | ファイザー・プロダクツ・インク | 異常な細胞増殖の治療用の二環式誘導体 |
EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
EP2103620A1 (en) | 2006-12-12 | 2009-09-23 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
MX2009007610A (es) | 2007-02-06 | 2009-07-24 | Boehringer Ingelheim Int | Heterociclicos biciclicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion. |
SI2245026T1 (sl) | 2008-02-07 | 2012-12-31 | Boehringer Ingelheim International Gmbh | Spirociklični heterocikli, zdravila, ki vsebujejo te spojine, njihova uporaba in postopek za njihovo pripravo |
WO2009113560A1 (ja) | 2008-03-12 | 2009-09-17 | 武田薬品工業株式会社 | 縮合複素環化合物 |
BRPI0912170A2 (pt) | 2008-05-13 | 2015-10-13 | Astrazeneca Ab | composto, forma a, processo para a preparação da mesma, composição farmacêutica, uso de um composto, e, método para tratar um câncer em um animal de sangue quente |
WO2010015522A1 (de) | 2008-08-08 | 2010-02-11 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
TWI577664B (zh) | 2009-01-16 | 2017-04-11 | 艾克塞里克斯公司 | N-(4-{〔6,7-雙(甲氧基)喹啉-4-基〕氧基}苯基)-n’-(4-氟苯基)環丙烷-1,1-二甲醯胺蘋果酸鹽、包含其之醫藥組合物及其用途 |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
WO2011153050A1 (en) | 2010-06-02 | 2011-12-08 | The Trustees Of The University Of Pennsylvania | Methods and use of compounds that bind to her2/neu receptor complex |
WO2011153049A1 (en) | 2010-06-02 | 2011-12-08 | The Trustees Of The University Of Pennsylvania | Methods and use of compounds that bind to her2/neu receptor complex |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
US20130084286A1 (en) | 2011-08-31 | 2013-04-04 | Thomas E. Januario | Diagnostic markers |
US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
KR101589632B1 (ko) | 2014-06-03 | 2016-02-01 | 한국과학기술연구원 | 항암활성을 가지는 6-벤질옥시퀴나졸린-7-일유레아 유도체 |
WO2017003668A1 (en) | 2015-07-01 | 2017-01-05 | California Institute Of Technology | Cationic mucic acid polymer-based delivery systems |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
CA3099440A1 (en) | 2018-06-13 | 2019-12-19 | California Institute Of Technology | Nanoparticles for crossing the blood brain barrier and methods of treatment using the same |
US20230126204A1 (en) | 2020-02-03 | 2023-04-27 | Boehringer Ingelheim International Gmbh | [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS |
CN115052881A (zh) * | 2020-02-03 | 2022-09-13 | 勃林格殷格翰国际有限公司 | 作为HER2抑制剂的[1,3]二嗪并[5,4-d]嘧啶 |
CN113429390B (zh) * | 2020-03-23 | 2022-04-15 | 苏州恩华生物医药科技有限公司 | 喹唑啉衍生物及其应用 |
US11608343B2 (en) * | 2020-04-24 | 2023-03-21 | Boehringer Ingelheim International Gmbh | Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors |
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US5679683A (en) * | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
ZA986729B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
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MXPA02012870A (es) * | 2000-06-22 | 2003-05-14 | Pfizer Prod Inc | Derivados biciclicos sustituidos para el tratamiento del crecimiento celular anormal. |
RS46404A (en) * | 2001-12-12 | 2006-10-27 | Pfizer Products Inc. | Salt forms of e-2-methoxy-n-(3-(4-(3-methyul-pyridin-3- yloxy)-phenylamino)-quinazolin-6-yl)-allyl)-acetamide,its preparation and its use against cancer |
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2002
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- 2002-11-04 WO PCT/IB2002/004636 patent/WO2003049740A1/en active Application Filing
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- 2002-11-04 HU HU0501069A patent/HUP0501069A2/hu unknown
- 2002-11-04 CA CA002469670A patent/CA2469670A1/en not_active Abandoned
- 2002-11-04 PL PL02373848A patent/PL373848A1/xx not_active Application Discontinuation
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- 2002-11-04 KR KR10-2004-7009022A patent/KR20040063948A/ko not_active Application Discontinuation
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- 2002-11-04 JP JP2003550789A patent/JP4181502B2/ja not_active Expired - Fee Related
- 2002-11-04 CN CNA028237293A patent/CN1602195A/zh active Pending
- 2002-12-10 PE PE2002001190A patent/PE20030760A1/es not_active Application Discontinuation
- 2002-12-10 US US10/315,863 patent/US20030171386A1/en not_active Abandoned
- 2002-12-10 DO DO2002000545A patent/DOP2002000545A/es unknown
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- 2002-12-10 AR ARP020104778A patent/AR037771A1/es unknown
- 2002-12-12 GT GT200200273A patent/GT200200273A/es unknown
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2004
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- 2004-05-31 ZA ZA200404264A patent/ZA200404264B/en unknown
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- 2004-06-09 HR HR20040529A patent/HRP20040529A2/hr not_active Application Discontinuation
- 2004-06-10 EC EC2004005146A patent/ECSP045146A/es unknown
- 2004-06-11 TN TNP2004000111A patent/TNSN04111A1/fr unknown
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Also Published As
Publication number | Publication date |
---|---|
NO20042882L (no) | 2004-07-07 |
BR0214499A (pt) | 2005-05-10 |
TNSN04111A1 (fr) | 2006-06-01 |
DOP2002000545A (es) | 2003-06-16 |
OA12734A (en) | 2006-06-28 |
TW200301121A (en) | 2003-07-01 |
JP2005527486A (ja) | 2005-09-15 |
PA8561301A1 (es) | 2003-12-30 |
WO2003049740A1 (en) | 2003-06-19 |
PE20030760A1 (es) | 2003-09-05 |
HRP20040529A2 (en) | 2004-10-31 |
AP2004003058A0 (en) | 2004-06-30 |
IS7233A (is) | 2004-04-26 |
IL161908A0 (en) | 2005-11-20 |
KR20040063948A (ko) | 2004-07-14 |
EA200400680A1 (ru) | 2005-06-30 |
AU2002339687A1 (en) | 2003-06-23 |
CN1602195A (zh) | 2005-03-30 |
HUP0501069A2 (en) | 2006-06-28 |
MA27154A1 (fr) | 2005-01-03 |
CA2469670A1 (en) | 2003-06-19 |
EP1465632A1 (en) | 2004-10-13 |
ECSP045146A (es) | 2004-07-23 |
US20030171386A1 (en) | 2003-09-11 |
JP4181502B2 (ja) | 2008-11-19 |
PL373848A1 (en) | 2005-09-19 |
MXPA04004107A (es) | 2004-07-23 |
GT200200273A (es) | 2003-10-03 |
AR037771A1 (es) | 2004-12-01 |
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