IT1254469B - Derivati benzopiranici e benzotiopiranici - Google Patents

Derivati benzopiranici e benzotiopiranici

Info

Publication number
IT1254469B
IT1254469B ITMI920408A ITMI920408A IT1254469B IT 1254469 B IT1254469 B IT 1254469B IT MI920408 A ITMI920408 A IT MI920408A IT MI920408 A ITMI920408 A IT MI920408A IT 1254469 B IT1254469 B IT 1254469B
Authority
IT
Italy
Prior art keywords
compounds
benzothiopyranic
benzopyranic
derivatives
treatment
Prior art date
Application number
ITMI920408A
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of ITMI920408A0 publication Critical patent/ITMI920408A0/it
Priority to ITMI920408A priority Critical patent/IT1254469B/it
Priority to US07/888,775 priority patent/US5403842A/en
Priority to SG1996004802A priority patent/SG65570A1/en
Priority to EP93301264A priority patent/EP0558245A1/en
Priority to HR930210A priority patent/HRP930210A2/hr
Priority to RO94-01404A priority patent/RO112111B1/ro
Priority to MX9300977A priority patent/MX9300977A/es
Priority to CZ942059A priority patent/CZ205994A3/cs
Priority to CA002090156A priority patent/CA2090156A1/en
Priority to SK1007-94A priority patent/SK280143B6/sk
Priority to PL93304889A priority patent/PL175556B1/pl
Priority to AU36296/93A priority patent/AU3629693A/en
Priority to HU9402443A priority patent/HUT72448A/hu
Priority to PCT/EP1993/000420 priority patent/WO1993017007A1/en
Priority to RU94043324A priority patent/RU2128656C1/ru
Priority to IL10482493A priority patent/IL104824A/en
Priority to LVP-93-136A priority patent/LV10099B/en
Priority to DZ930019A priority patent/DZ1666A1/fr
Priority to ZA931278A priority patent/ZA931278B/xx
Priority to AU33773/93A priority patent/AU660067B2/en
Priority to LTIP354A priority patent/LT3038B/lt
Priority to EG1193A priority patent/EG20333A/xx
Priority to JP5036605A priority patent/JPH069606A/ja
Priority to TNTNSN93020A priority patent/TNSN93020A1/fr
Priority to SI19939300094A priority patent/SI9300094A/sl
Priority to NZ245995A priority patent/NZ245995A/en
Priority to TW082103988A priority patent/TW382628B/zh
Publication of ITMI920408A1 publication Critical patent/ITMI920408A1/it
Priority to KR1019940702823A priority patent/KR950700276A/ko
Priority to BG98990A priority patent/BG61946B1/bg
Priority to FI943876A priority patent/FI943876A0/fi
Priority to NO943140A priority patent/NO943140L/no
Priority to US08/299,188 priority patent/US5605896A/en
Priority to EE9400374A priority patent/EE03177B1/xx
Application granted granted Critical
Publication of IT1254469B publication Critical patent/IT1254469B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Vengono descritti nuovi derivati benzopiranici e benzotiopiranici dotati di elevata affinità per i recettori ?-adrenergici e serotoninergici 5HT1A. Tali composti possono essere utili agenti terapeutici per il trattamento delle patologie legate a detti sistemi recettoriali. A differenza degli ?-antagonisti noti, tali composti hanno scarsa attività sulla pressione e sono di bassa tossicità. Possono quindi risultare particolarmente utili come agenti terapeutici per il trattamento dei disturbi della minzione associati a disfunzioni ostruttive del basso tratto urinario, quali l'ipertrofia prostatica benigna, nonché per altre malattie di questo distretto. Vengono anche descritti i procedimenti per ottenere detti composti.
ITMI920408A 1992-02-25 1992-02-25 Derivati benzopiranici e benzotiopiranici IT1254469B (it)

Priority Applications (33)

Application Number Priority Date Filing Date Title
ITMI920408A IT1254469B (it) 1992-02-25 1992-02-25 Derivati benzopiranici e benzotiopiranici
US07/888,775 US5403842A (en) 1992-02-25 1992-05-26 Benzopyran and benzothiopyran derivatives
SG1996004802A SG65570A1 (en) 1992-02-25 1993-02-22 Heterobicyclic compounds
EP93301264A EP0558245A1 (en) 1992-02-25 1993-02-22 Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors
HR930210A HRP930210A2 (en) 1992-02-25 1993-02-22 Heterobicyclic compounds and pharmaceutical preparations containing them
RO94-01404A RO112111B1 (ro) 1992-02-25 1993-02-23 Compuşi heterobiciclici, procedee pentru prepararea acestora şi compoziţii farmaceutice care îi conţin
MX9300977A MX9300977A (es) 1992-02-25 1993-02-23 Compuetos heterobiciclicos.
CZ942059A CZ205994A3 (en) 1992-02-25 1993-02-23 Heterobicyclic compounds
CA002090156A CA2090156A1 (en) 1992-02-25 1993-02-23 Heterobicyclic compounds
SK1007-94A SK280143B6 (sk) 1992-02-25 1993-02-23 Heterobicyklické zlúčeniny, spôsoby ich prípravy a
PL93304889A PL175556B1 (pl) 1992-02-25 1993-02-23 Pochodne benzopiranu, benzotiopiranu i benzofuranu oraz sposób ich wytwarzania
AU36296/93A AU3629693A (en) 1992-02-25 1993-02-23 Heterobicyclic compounds
HU9402443A HUT72448A (en) 1992-02-25 1993-02-23 O-, n- ors-containing heterobicyclic compounds, pharmaceutical compositions comprising them and process for their preparation
PCT/EP1993/000420 WO1993017007A1 (en) 1992-02-25 1993-02-23 Heterobicyclic compounds
RU94043324A RU2128656C1 (ru) 1992-02-25 1993-02-23 Гетеробициклическое соединение, фармацевтическая композиция, способы получения гетеробициклического соединения
IL10482493A IL104824A (en) 1992-02-25 1993-02-23 Heterobicyclic compounds and pharmaceutical compositions containing them
LVP-93-136A LV10099B (en) 1992-02-25 1993-02-24 Bicyclic heterocyclic compounds
DZ930019A DZ1666A1 (fr) 1992-02-25 1993-02-24 Composés hétérobicycliques.
ZA931278A ZA931278B (en) 1992-02-25 1993-02-24 Heterobicyclic compounds
AU33773/93A AU660067B2 (en) 1992-02-25 1993-02-24 Benzopyranone derivatives and analogues
LTIP354A LT3038B (en) 1992-02-25 1993-02-24 Heterobicyclic compounds
SI19939300094A SI9300094A (en) 1992-02-25 1993-02-25 Heterocyclic compounds
NZ245995A NZ245995A (en) 1992-02-25 1993-02-25 Benzopyran, benzothiopyran and benzofuran derivatives and pharmaceutical compositions
JP5036605A JPH069606A (ja) 1992-02-25 1993-02-25 ヘテロビサイクリック化合物
TNTNSN93020A TNSN93020A1 (fr) 1992-02-25 1993-02-25 Composes heterobicycliques
EG1193A EG20333A (en) 1992-02-25 1993-02-25 Process for preparing benzopyran and benzothiopyran derivatives and their use as pharmaceutical agent for urinary tract disturbances
TW082103988A TW382628B (en) 1992-02-25 1993-05-20 Heterobicyclic compounds and the use for the treatment of hypertension and urinary tract troubles
KR1019940702823A KR950700276A (ko) 1992-02-25 1994-08-17 헤테로고리 화합물(heterobicyclic compounds)
BG98990A BG61946B1 (bg) 1992-02-25 1994-08-19 Хетеробициклични съединения
FI943876A FI943876A0 (fi) 1992-02-25 1994-08-23 Heterobisykliset yhdisteet
NO943140A NO943140L (no) 1992-02-25 1994-08-25 Heterobicykliske forbindelser
US08/299,188 US5605896A (en) 1992-02-25 1994-08-31 Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
EE9400374A EE03177B1 (et) 1992-02-25 1994-11-10 Heterobitsüklilised ühendid, nende saamismeetod ja nimetatud ühendeid sisaldavad farmatseutilised kompositsioonid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920408A IT1254469B (it) 1992-02-25 1992-02-25 Derivati benzopiranici e benzotiopiranici

Publications (3)

Publication Number Publication Date
ITMI920408A0 ITMI920408A0 (it) 1992-02-25
ITMI920408A1 ITMI920408A1 (it) 1993-08-25
IT1254469B true IT1254469B (it) 1995-09-25

Family

ID=11362122

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI920408A IT1254469B (it) 1992-02-25 1992-02-25 Derivati benzopiranici e benzotiopiranici

Country Status (6)

Country Link
US (1) US5403842A (it)
KR (1) KR950700276A (it)
IT (1) IT1254469B (it)
RO (1) RO112111B1 (it)
RU (1) RU2128656C1 (it)
TN (1) TNSN93020A1 (it)

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JP2002513799A (ja) * 1998-05-06 2002-05-14 デューク・ユニバーシティー 膀胱および下部尿路症候群の治療方法
IT1312310B1 (it) 1999-05-07 2002-04-15 Recordati Ind Chimica E Farma Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale
DE60006954T2 (de) 1999-05-10 2004-10-21 Warner Lambert Co Aromatische amide
IT1313581B1 (it) * 1999-07-30 2002-09-09 Recordati Chem Pharm Derivati tienopirancarbossamidici.
US6306861B1 (en) 1999-07-30 2001-10-23 Recordati S.A. Chemical And Pharmaceutical Company Thienopyrancecarboxamide derivatives
US6387909B1 (en) 1999-07-30 2002-05-14 Recordati S.A. Chemical And Pharmaceutical Company Thienopyranecarboxamide derivatives
US6365591B1 (en) * 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
US6403594B1 (en) 1999-10-18 2002-06-11 Recordati, S.A. Chemical And Pharmaceutical Company Benzopyran derivatives
IT1314191B1 (it) * 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
SE0103650D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic heterocyclic compounds
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EP1353913A2 (en) * 2001-01-16 2003-10-22 AstraZeneca AB Therapeutic heterocyclic compounds
CA2433950A1 (en) 2001-01-16 2002-07-18 Timothy Davenport Therapeutic chromone compounds
RU2187306C1 (ru) * 2001-05-24 2002-08-20 Московская медицинская академия им. И.М.Сеченова Способ улучшения качества спермы
JP2006511500A (ja) * 2002-10-30 2006-04-06 メルク　エンド　カムパニー　インコーポレーテッド γ−アミノアミド系のケモカイン受容体活性調節剤
ES2341240T3 (es) * 2002-12-13 2010-06-17 Warner-Lambert Company Llc Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior.
US6916831B2 (en) * 2003-02-24 2005-07-12 The University Of North Carolina At Chapel Hill Flavone acetic acid analogs and methods of use thereof
SI1620085T1 (sl) * 2003-05-05 2008-12-31 Kissei Pharmaceutical Uporaba derivatov fenoksiocetne kisline za zdravljenje hiperaktivnega sečnega mehurja
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
AU2006222556B2 (en) * 2005-03-11 2011-09-29 Armaron Bio Pty Ltd Flavonoid compounds and uses thereof
CN102227420B (zh) * 2008-09-29 2015-06-24 西特里斯药业公司 作为沉默调节蛋白调节剂的喹唑啉酮、喹诺酮和相关的类似物
CN103819464B (zh) * 2014-03-11 2015-10-07 南京工业大学 硫色满类化合物及其合成方法和制备抗真菌药物的应用
AU2017218889A1 (en) 2016-02-09 2018-08-30 Pharmakea, Inc. Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
DK4069691T3 (da) 2019-12-06 2024-10-28 Vertex Pharma Substituerede tetrahydrofuraner som modulatorer af natriumkanaler
MA64853B1 (fr) 2021-06-04 2025-11-28 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物

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RO112111B1 (ro) 1997-05-30
KR950700276A (ko) 1995-01-16
ITMI920408A1 (it) 1993-08-25
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RU94043324A (ru) 1996-08-20
ITMI920408A0 (it) 1992-02-25
TNSN93020A1 (fr) 1994-03-17

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