AU3629693A - Heterobicyclic compounds - Google Patents

Heterobicyclic compounds

Info

Publication number
AU3629693A
AU3629693A AU36296/93A AU3629693A AU3629693A AU 3629693 A AU3629693 A AU 3629693A AU 36296/93 A AU36296/93 A AU 36296/93A AU 3629693 A AU3629693 A AU 3629693A AU 3629693 A AU3629693 A AU 3629693A
Authority
AU
Australia
Prior art keywords
heterobicyclic compounds
heterobicyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU36296/93A
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Rodolfo Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati Industria Chimica e Farmaceutica SpA
Original Assignee
Recordati SA
Recordati Industria Chimica e Farmaceutica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI920408A external-priority patent/IT1254469B/en
Application filed by Recordati SA, Recordati Industria Chimica e Farmaceutica SpA filed Critical Recordati SA
Publication of AU3629693A publication Critical patent/AU3629693A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
AU36296/93A 1992-02-25 1993-02-23 Heterobicyclic compounds Abandoned AU3629693A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI920408A IT1254469B (en) 1992-02-25 1992-02-25 BENZOPYRANIC AND BENZOTHIOPYRANIC DERIVATIVES
ITMI92A0408 1992-02-25
US07/888,775 US5403842A (en) 1992-02-25 1992-05-26 Benzopyran and benzothiopyran derivatives
US888775 1992-05-26

Publications (1)

Publication Number Publication Date
AU3629693A true AU3629693A (en) 1993-09-13

Family

ID=26330842

Family Applications (2)

Application Number Title Priority Date Filing Date
AU36296/93A Abandoned AU3629693A (en) 1992-02-25 1993-02-23 Heterobicyclic compounds
AU33773/93A Ceased AU660067B2 (en) 1992-02-25 1993-02-24 Benzopyranone derivatives and analogues

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU33773/93A Ceased AU660067B2 (en) 1992-02-25 1993-02-24 Benzopyranone derivatives and analogues

Country Status (25)

Country Link
EP (1) EP0558245A1 (en)
JP (1) JPH069606A (en)
AU (2) AU3629693A (en)
BG (1) BG61946B1 (en)
CA (1) CA2090156A1 (en)
CZ (1) CZ205994A3 (en)
DZ (1) DZ1666A1 (en)
EE (1) EE03177B1 (en)
EG (1) EG20333A (en)
FI (1) FI943876A (en)
HR (1) HRP930210A2 (en)
HU (1) HUT72448A (en)
IL (1) IL104824A (en)
LT (1) LT3038B (en)
LV (1) LV10099B (en)
MX (1) MX9300977A (en)
NO (1) NO943140L (en)
NZ (1) NZ245995A (en)
PL (1) PL175556B1 (en)
SG (1) SG65570A1 (en)
SI (1) SI9300094A (en)
SK (1) SK280143B6 (en)
TW (1) TW382628B (en)
WO (1) WO1993017007A1 (en)
ZA (1) ZA931278B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU655106B2 (en) * 1992-03-31 1994-12-01 Les Laboratoires Servier New 3',5'-di-tert-butyl-4'-hydroxy flavones, process for the preparation thereof and pharmaceutical compositions containing them

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IT1266582B1 (en) * 1993-07-30 1997-01-09 Recordati Chem Pharm (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES
GB9317071D0 (en) * 1993-08-17 1993-09-29 Univ Strathclyde Flavonoids
EP0690051B1 (en) * 1994-01-14 2001-07-18 Azwell Inc. Diazacycloalkanealkylsulfonamide derivative
FR2717175B1 (en) * 1994-03-11 1996-06-14 Adir New alkylaminoindane compounds, processes for their preparation and pharmaceutical compositions containing them.
IL112764A0 (en) * 1994-03-18 1995-05-26 Ferrer Int New chromene derivatives
ES2101620B1 (en) * 1994-03-18 1998-04-01 Ferrer Int NEW COMPOUND DERIVED FROM CHROMENE.
PT753511E (en) * 1994-03-30 2001-11-30 Zeria Pharm Co Ltd 4-INDOL-1-BUTYRIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS INHIBITORS OF ALPHA-1-ADRENERGIC RECEPTORS AND 5-ALPHA-REDUTASES OF TESTOSTERONE
US5503843A (en) * 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
DE4425146A1 (en) * 1994-07-15 1996-01-18 Basf Ag Use of heterocyclic compounds
GB9417135D0 (en) * 1994-08-23 1994-10-12 Medinnova S F Method
HUP9602977A3 (en) * 1995-02-28 1998-01-28 Daiichi Asubio Pharma Co Ltd Arylpiperidine and arylpiperazine derivatives and drugs containing the same
GB9507288D0 (en) 1995-04-07 1995-05-31 Sod Conseils Rech Applic Phenoxyethylamine derivatives with high affinity for 5-HT1A receptors
US5859014A (en) * 1995-06-09 1999-01-12 Syntex (U.S.A.) Inc. Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as α1 -adrenergic receptor antagonists
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JPH0967367A (en) * 1995-06-23 1997-03-11 Suntory Ltd Thiopyran derivative
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US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
FR2745815B1 (en) * 1996-03-08 1998-06-26 Synthelabo BENZOFURANE DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
WO1997032870A1 (en) * 1996-03-08 1997-09-12 Synthelabo 2-aminoethyl-benzofuran derivatives, preparation thereof and therapeutical use thereof
NZ333519A (en) * 1996-08-22 1999-10-28 Hoechst Marion Roussel Inc Troponyl piperazines as selective dopamine d4 receptor ligands
HUP0100048A3 (en) * 1997-05-12 2002-12-28 Ortho Mcneil Pharm Inc Arylsubstituted piperazine-derivatives, useful in the treatement of benign prostatic hyperlasia use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them
AU2002300904B2 (en) * 1997-05-12 2004-12-23 Ortho-Mcneil Pharmaceutical, Inc. Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
EP1020443B1 (en) 1997-06-04 2003-09-10 Azwell Inc. Process for producing piperazinesulfonamide derivatives and salts thereof
AU8130298A (en) * 1997-07-15 1999-02-10 Sankyo Company Limited Piperazine derivatives
IT1313581B1 (en) * 1999-07-30 2002-09-09 Recordati Chem Pharm TIENOPIRANCARBOSSAMIDICI DERIVATIVES.
US6306861B1 (en) 1999-07-30 2001-10-23 Recordati S.A. Chemical And Pharmaceutical Company Thienopyrancecarboxamide derivatives
US6387909B1 (en) 1999-07-30 2002-05-14 Recordati S.A. Chemical And Pharmaceutical Company Thienopyranecarboxamide derivatives
DE19941657A1 (en) * 1999-09-01 2001-03-08 Schwabe Willmar Gmbh & Co Cinnamic acid nitriles, process for their preparation and use
US6403594B1 (en) 1999-10-18 2002-06-11 Recordati, S.A. Chemical And Pharmaceutical Company Benzopyran derivatives
IT1314192B1 (en) * 1999-10-18 2002-12-06 Recordati Chem Pharm BENZOPYRANIC DERIVATIVES
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CN1150176C (en) 2002-05-22 2004-05-19 上海医药工业研究院 Aralkylone pipeazine derivative and its application
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US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
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US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008507518A (en) 2004-07-22 2008-03-13 ピーティーシー セラピューティクス，インコーポレーテッド Thienopyridine for treating hepatitis C
BRPI0608353A2 (en) 2005-02-17 2009-12-01 Wyeth Corp indole, benzothiophene, benzofuran and indene cycloalkyl fused derivatives
SG196775A1 (en) * 2008-09-29 2014-02-13 Sirtris Pharmaceuticals Inc Chromenone analogs as sirtuin modulators
CZ2012242A3 (en) 2012-04-10 2013-09-04 Univerzita Palackého Use of copper complexes containing 2-phenyl-3-hydroquinolin-4(1H)-one and derivatives of 1,10-fenanthrolin for preparing medicaments intended for treating tumor diseases
CA3013917A1 (en) 2016-02-09 2017-08-17 Pharmakea, Inc. Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
TW202031644A (en) * 2018-11-06 2020-09-01 日商第一三共股份有限公司 Benzimidazole derivative
WO2021097475A1 (en) * 2019-11-11 2021-05-20 Southwest Research Institute Recrystallized hi-6 dimethylsulfate
KR20220124176A (en) 2019-12-06 2022-09-13 버텍스 파마슈티칼스 인코포레이티드 Substituted tetrahydrofuran as a modulator of sodium channels
KR20240031300A (en) 2021-06-04 2024-03-07 버텍스 파마슈티칼스 인코포레이티드 N-(Hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide as a sodium channel modulator
TW202334089A (en) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Pparg inverse agonists and uses thereof
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU655106B2 (en) * 1992-03-31 1994-12-01 Les Laboratoires Servier New 3',5'-di-tert-butyl-4'-hydroxy flavones, process for the preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HU9402443D0 (en) 1994-10-28
CA2090156A1 (en) 1993-08-26
NO943140D0 (en) 1994-08-25
EE03177B1 (en) 1999-04-15
PL175556B1 (en) 1999-01-29
NZ245995A (en) 1994-09-27
LV10099B (en) 1995-02-20
LT3038B (en) 1994-09-25
LTIP354A (en) 1994-04-25
EP0558245A1 (en) 1993-09-01
FI943876A0 (en) 1994-08-23
CZ205994A3 (en) 1995-02-15
SG65570A1 (en) 1999-06-22
LV10099A (en) 1994-05-10
AU660067B2 (en) 1995-06-08
BG98990A (en) 1995-05-31
TW382628B (en) 2000-02-21
ZA931278B (en) 1993-11-18
EG20333A (en) 1998-10-31
HUT72448A (en) 1996-04-29
IL104824A0 (en) 1993-06-10
DZ1666A1 (en) 2002-02-17
AU3377393A (en) 1993-08-26
BG61946B1 (en) 1998-10-30
SI9300094A (en) 1993-09-30
SK280143B6 (en) 1999-09-10
NO943140L (en) 1994-08-25
FI943876A (en) 1994-08-23
MX9300977A (en) 1993-12-01
WO1993017007A1 (en) 1993-09-02
JPH069606A (en) 1994-01-18
IL104824A (en) 1999-12-22
HRP930210A2 (en) 1995-06-30
SK100794A3 (en) 1995-04-12

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