AU3377393A - Benzopyranone derivatives and analogues - Google Patents

Benzopyranone derivatives and analogues

Info

Publication number
AU3377393A
AU3377393A AU33773/93A AU3377393A AU3377393A AU 3377393 A AU3377393 A AU 3377393A AU 33773/93 A AU33773/93 A AU 33773/93A AU 3377393 A AU3377393 A AU 3377393A AU 3377393 A AU3377393 A AU 3377393A
Authority
AU
Australia
Prior art keywords
analogues
benzopyranone derivatives
benzopyranone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU33773/93A
Other versions
AU660067B2 (en
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Rodolfo Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati SA
Original Assignee
Recordati SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI920408A external-priority patent/IT1254469B/en
Application filed by Recordati SA filed Critical Recordati SA
Publication of AU3377393A publication Critical patent/AU3377393A/en
Application granted granted Critical
Publication of AU660067B2 publication Critical patent/AU660067B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
AU33773/93A 1992-02-25 1993-02-24 Benzopyranone derivatives and analogues Ceased AU660067B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI92A0408 1992-02-25
ITMI920408A IT1254469B (en) 1992-02-25 1992-02-25 BENZOPYRANIC AND BENZOTHIOPYRANIC DERIVATIVES
US888775 1992-05-26
US07/888,775 US5403842A (en) 1992-02-25 1992-05-26 Benzopyran and benzothiopyran derivatives

Publications (2)

Publication Number Publication Date
AU3377393A true AU3377393A (en) 1993-08-26
AU660067B2 AU660067B2 (en) 1995-06-08

Family

ID=26330842

Family Applications (2)

Application Number Title Priority Date Filing Date
AU36296/93A Abandoned AU3629693A (en) 1992-02-25 1993-02-23 Heterobicyclic compounds
AU33773/93A Ceased AU660067B2 (en) 1992-02-25 1993-02-24 Benzopyranone derivatives and analogues

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU36296/93A Abandoned AU3629693A (en) 1992-02-25 1993-02-23 Heterobicyclic compounds

Country Status (25)

Country Link
EP (1) EP0558245A1 (en)
JP (1) JPH069606A (en)
AU (2) AU3629693A (en)
BG (1) BG61946B1 (en)
CA (1) CA2090156A1 (en)
CZ (1) CZ205994A3 (en)
DZ (1) DZ1666A1 (en)
EE (1) EE03177B1 (en)
EG (1) EG20333A (en)
FI (1) FI943876A (en)
HR (1) HRP930210A2 (en)
HU (1) HUT72448A (en)
IL (1) IL104824A (en)
LT (1) LT3038B (en)
LV (1) LV10099B (en)
MX (1) MX9300977A (en)
NO (1) NO943140D0 (en)
NZ (1) NZ245995A (en)
PL (1) PL175556B1 (en)
SG (1) SG65570A1 (en)
SI (1) SI9300094A (en)
SK (1) SK280143B6 (en)
TW (1) TW382628B (en)
WO (1) WO1993017007A1 (en)
ZA (1) ZA931278B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU655106B2 (en) * 1992-03-31 1994-12-01 Les Laboratoires Servier New 3',5'-di-tert-butyl-4'-hydroxy flavones, process for the preparation thereof and pharmaceutical compositions containing them
AU666896B2 (en) * 1992-01-23 1996-02-29 Pfizer Inc. Benzopyran and related LTB4 antagonists

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IT1266582B1 (en) * 1993-07-30 1997-01-09 Recordati Chem Pharm (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES
GB9317071D0 (en) * 1993-08-17 1993-09-29 Univ Strathclyde Flavonoids
ES2159622T3 (en) * 1994-01-14 2001-10-16 Azwell Inc DERIVED FROM DIAZACICLOALCANOALQUILSULFONAMIDA.
FR2717175B1 (en) * 1994-03-11 1996-06-14 Adir New alkylaminoindane compounds, processes for their preparation and pharmaceutical compositions containing them.
ES2101620B1 (en) * 1994-03-18 1998-04-01 Ferrer Int NEW COMPOUND DERIVED FROM CHROMENE.
IL112764A0 (en) * 1994-03-18 1995-05-26 Ferrer Int New chromene derivatives
US5760040A (en) * 1994-03-30 1998-06-02 Zeria Pharmaceutical Co., Ltd. Indole derivative for treating overproduction of dihydrotestosterone
US5503843A (en) * 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
DE4425146A1 (en) * 1994-07-15 1996-01-18 Basf Ag Use of heterocyclic compounds
GB9417135D0 (en) * 1994-08-23 1994-10-12 Medinnova S F Method
CA2188924C (en) * 1995-02-28 2008-04-08 Hirokazu Annoura Arylpiperidine and arylpiperazine derivatives and drugs containing the same
GB9507288D0 (en) * 1995-04-07 1995-05-31 Sod Conseils Rech Applic Phenoxyethylamine derivatives with high affinity for 5-HT1A receptors
US5859014A (en) * 1995-06-09 1999-01-12 Syntex (U.S.A.) Inc. Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as α1 -adrenergic receptor antagonists
ES2157366T3 (en) * 1995-06-09 2001-08-16 Hoffmann La Roche DERIVATIVES OF PYRIMIDINDIONA, PIRIMIDINTRIONA, TRIACINDIONA AS ANTAGONISTS OF ALFA-1-ADRENERGIC RECEPTORS.
JPH0967367A (en) * 1995-06-23 1997-03-11 Suntory Ltd Thiopyran derivative
AU4153496A (en) * 1995-10-20 1997-05-07 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
IT1282705B1 (en) * 1996-02-28 1998-03-31 Recordati Chem Pharm USE OF 5-HT | A SEROTONINERGIC RECEPTOR ANTAGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
JP2000506157A (en) * 1996-03-08 2000-05-23 サンテラボ (2-Aminoethyl) benzofuran derivatives, their production and their therapeutic use
FR2745815B1 (en) * 1996-03-08 1998-06-26 Synthelabo BENZOFURANE DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
AU3817197A (en) * 1996-08-22 1998-03-06 Hoechst Marion Roussel, Inc. Troponyl piperazines as selective dopamine d4 receptor ligands
AU2002300904B2 (en) * 1997-05-12 2004-12-23 Ortho-Mcneil Pharmaceutical, Inc. Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
EP0984777B1 (en) 1997-05-12 2003-09-17 Ortho-Mcneil Pharmaceutical, Inc. Arylsubstituted piperazines useful in the treatement of benign prostatic hyperlasia
AU7455798A (en) 1997-06-04 1998-12-21 Nippon Shoji Kaisha, Ltd. Process for producing piperazinesulfonamide derivatives and salts thereof
WO1999003833A1 (en) * 1997-07-15 1999-01-28 Sankyo Company, Limited Piperazine derivatives
US6387909B1 (en) 1999-07-30 2002-05-14 Recordati S.A. Chemical And Pharmaceutical Company Thienopyranecarboxamide derivatives
US6306861B1 (en) 1999-07-30 2001-10-23 Recordati S.A. Chemical And Pharmaceutical Company Thienopyrancecarboxamide derivatives
IT1313581B1 (en) * 1999-07-30 2002-09-09 Recordati Chem Pharm TIENOPIRANCARBOSSAMIDICI DERIVATIVES.
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US6403594B1 (en) 1999-10-18 2002-06-11 Recordati, S.A. Chemical And Pharmaceutical Company Benzopyran derivatives
IT1314192B1 (en) * 1999-10-18 2002-12-06 Recordati Chem Pharm BENZOPYRANIC DERIVATIVES
JP2002113006A (en) 2000-10-10 2002-04-16 Toshiba Medical System Co Ltd Method of setting for diagnostic apparatus, and diagnostic instrument
CN1150176C (en) 2002-05-22 2004-05-19 上海医药工业研究院 Aralkylone pipeazine derivative and its application
US7247725B2 (en) * 2002-10-30 2007-07-24 Merck & Co., Inc. Gamma-aminoamide modulators of chemokine receptor activity
BRPI0511834A (en) 2004-07-14 2008-01-08 Ptc Therapeutics Inc methods for treating hepatitis c
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019832A1 (en) 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
BRPI0608353A2 (en) 2005-02-17 2009-12-01 Wyeth Corp indole, benzothiophene, benzofuran and indene cycloalkyl fused derivatives
CN102227417B (en) * 2008-09-29 2015-09-16 西特里斯药业公司 As the chromene keto analog of Sirtuin conditioning agent
CZ304045B6 (en) 2012-04-10 2013-09-04 Univerzita Palackého Use of copper complexes containing 2-phenyl-3-hydroxyquinolin-4(1H)-one and 1,10-phenanthroline derivatives for preparing medicaments intended for the treatment of tumor diseases
CN108884049A (en) 2016-02-09 2018-11-23 法玛克亚公司 2 inhibitor of quinolinone lysyloxidase sample and application thereof
TW202031644A (en) * 2018-11-06 2020-09-01 日商第一三共股份有限公司 Benzimidazole derivative
CA3160428A1 (en) 2019-11-11 2021-05-20 Southwest Research Institute Recrystallized hi-6 dimethylsulfate
US11834441B2 (en) 2019-12-06 2023-12-05 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
EP4347031A1 (en) 2021-06-04 2024-04-10 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
TW202334089A (en) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Pparg inverse agonists and uses thereof
CN115160279B (en) * 2022-07-27 2023-11-24 中国药科大学 Benzopyrone compounds, pharmaceutical compositions and uses

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU666896B2 (en) * 1992-01-23 1996-02-29 Pfizer Inc. Benzopyran and related LTB4 antagonists
AU655106B2 (en) * 1992-03-31 1994-12-01 Les Laboratoires Servier New 3',5'-di-tert-butyl-4'-hydroxy flavones, process for the preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU3629693A (en) 1993-09-13
EE03177B1 (en) 1999-04-15
LT3038B (en) 1994-09-25
JPH069606A (en) 1994-01-18
AU660067B2 (en) 1995-06-08
MX9300977A (en) 1993-12-01
HU9402443D0 (en) 1994-10-28
IL104824A0 (en) 1993-06-10
SK100794A3 (en) 1995-04-12
ZA931278B (en) 1993-11-18
PL175556B1 (en) 1999-01-29
EP0558245A1 (en) 1993-09-01
EG20333A (en) 1998-10-31
FI943876A0 (en) 1994-08-23
FI943876A (en) 1994-08-23
IL104824A (en) 1999-12-22
SG65570A1 (en) 1999-06-22
NO943140L (en) 1994-08-25
BG61946B1 (en) 1998-10-30
HRP930210A2 (en) 1995-06-30
NZ245995A (en) 1994-09-27
NO943140D0 (en) 1994-08-25
LTIP354A (en) 1994-04-25
DZ1666A1 (en) 2002-02-17
SK280143B6 (en) 1999-09-10
CA2090156A1 (en) 1993-08-26
LV10099B (en) 1995-02-20
LV10099A (en) 1994-05-10
CZ205994A3 (en) 1995-02-15
HUT72448A (en) 1996-04-29
WO1993017007A1 (en) 1993-09-02
BG98990A (en) 1995-05-31
SI9300094A (en) 1993-09-30
TW382628B (en) 2000-02-21

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Legal Events

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired