DK1529530T5 - Glucokinase påvirkende forbindelser - Google Patents

Glucokinase påvirkende forbindelser

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Publication number
DK1529530T5
DK1529530T5 DK04028298T DK04028298T DK1529530T5 DK 1529530 T5 DK1529530 T5 DK 1529530T5 DK 04028298 T DK04028298 T DK 04028298T DK 04028298 T DK04028298 T DK 04028298T DK 1529530 T5 DK1529530 T5 DK 1529530T5
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DK
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Prior art keywords
glucokinase
affecting compounds
affecting
compounds
glucokinase affecting
Prior art date
Application number
DK04028298T
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English (en)
Other versions
DK1529530T3 (da
Inventor
Craig Johnstone
Roger James
Darren Mckerrecher
Scott Boyd
Peter Caulkett
Rodney Hargreaves
Clifford David Jones
Suzanne Bowker
Michael Howard Block
Original Assignee
Astrazeneca Ab
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Publication of DK1529530T3 publication Critical patent/DK1529530T3/da
Publication of DK1529530T5 publication Critical patent/DK1529530T5/da

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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SE0102764D0 (sv) 2001-08-17
HUP0401213A3 (en) 2011-03-28
PT1568367E (pt) 2007-06-28
CN101492416A (zh) 2009-07-29
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ATE397928T1 (de) 2008-07-15
CY1108267T1 (el) 2014-02-12
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US20050080106A1 (en) 2005-04-14
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EP1674097A1 (en) 2006-06-28
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EP1661569A1 (en) 2006-05-31
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ATE403427T1 (de) 2008-08-15
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EP1661568A1 (en) 2006-05-31
DE60219698T2 (de) 2007-12-27
HK1090291A1 (en) 2006-12-22
AU2002321462B2 (en) 2007-09-20
SI1529530T1 (sl) 2006-12-31
IL160219A0 (en) 2004-07-25
SI1568367T1 (sl) 2007-08-31
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DE60227121D1 (de) 2008-07-24
JP3987829B2 (ja) 2007-10-10

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